A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry
The SARS-CoV-2 spike protein contains a multi-basic cleavage site. Here, the authors show how this multi-basic cleavage site affects entry of SARS-CoV-2 into cells and transmission in the hamster model and identify host factors affecting entry of SARS-CoV-2 in a genome-wide CRISPR screen.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/614198775ef44e57a0a5f7bb249a104c |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:614198775ef44e57a0a5f7bb249a104c |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:614198775ef44e57a0a5f7bb249a104c2021-12-02T14:10:57ZA genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry10.1038/s41467-021-21213-42041-1723https://doaj.org/article/614198775ef44e57a0a5f7bb249a104c2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21213-4https://doaj.org/toc/2041-1723The SARS-CoV-2 spike protein contains a multi-basic cleavage site. Here, the authors show how this multi-basic cleavage site affects entry of SARS-CoV-2 into cells and transmission in the hamster model and identify host factors affecting entry of SARS-CoV-2 in a genome-wide CRISPR screen.Yunkai ZhuFei FengGaowei HuYuyan WangYin YuYuanfei ZhuWei XuXia CaiZhiping SunWendong HanRong YeDi QuQiang DingXinxin HuangHongjun ChenWei XuYouhua XieQiliang CaiZhenghong YuanRong ZhangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Yunkai Zhu Fei Feng Gaowei Hu Yuyan Wang Yin Yu Yuanfei Zhu Wei Xu Xia Cai Zhiping Sun Wendong Han Rong Ye Di Qu Qiang Ding Xinxin Huang Hongjun Chen Wei Xu Youhua Xie Qiliang Cai Zhenghong Yuan Rong Zhang A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry |
| description |
The SARS-CoV-2 spike protein contains a multi-basic cleavage site. Here, the authors show how this multi-basic cleavage site affects entry of SARS-CoV-2 into cells and transmission in the hamster model and identify host factors affecting entry of SARS-CoV-2 in a genome-wide CRISPR screen. |
| format |
article |
| author |
Yunkai Zhu Fei Feng Gaowei Hu Yuyan Wang Yin Yu Yuanfei Zhu Wei Xu Xia Cai Zhiping Sun Wendong Han Rong Ye Di Qu Qiang Ding Xinxin Huang Hongjun Chen Wei Xu Youhua Xie Qiliang Cai Zhenghong Yuan Rong Zhang |
| author_facet |
Yunkai Zhu Fei Feng Gaowei Hu Yuyan Wang Yin Yu Yuanfei Zhu Wei Xu Xia Cai Zhiping Sun Wendong Han Rong Ye Di Qu Qiang Ding Xinxin Huang Hongjun Chen Wei Xu Youhua Xie Qiliang Cai Zhenghong Yuan Rong Zhang |
| author_sort |
Yunkai Zhu |
| title |
A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry |
| title_short |
A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry |
| title_full |
A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry |
| title_fullStr |
A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry |
| title_full_unstemmed |
A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry |
| title_sort |
genome-wide crispr screen identifies host factors that regulate sars-cov-2 entry |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/614198775ef44e57a0a5f7bb249a104c |
| work_keys_str_mv |
AT yunkaizhu agenomewidecrisprscreenidentifieshostfactorsthatregulatesarscov2entry AT feifeng agenomewidecrisprscreenidentifieshostfactorsthatregulatesarscov2entry AT gaoweihu agenomewidecrisprscreenidentifieshostfactorsthatregulatesarscov2entry AT yuyanwang agenomewidecrisprscreenidentifieshostfactorsthatregulatesarscov2entry AT yinyu agenomewidecrisprscreenidentifieshostfactorsthatregulatesarscov2entry AT yuanfeizhu agenomewidecrisprscreenidentifieshostfactorsthatregulatesarscov2entry AT weixu agenomewidecrisprscreenidentifieshostfactorsthatregulatesarscov2entry AT xiacai agenomewidecrisprscreenidentifieshostfactorsthatregulatesarscov2entry AT zhipingsun agenomewidecrisprscreenidentifieshostfactorsthatregulatesarscov2entry AT wendonghan agenomewidecrisprscreenidentifieshostfactorsthatregulatesarscov2entry AT rongye agenomewidecrisprscreenidentifieshostfactorsthatregulatesarscov2entry AT diqu agenomewidecrisprscreenidentifieshostfactorsthatregulatesarscov2entry AT qiangding agenomewidecrisprscreenidentifieshostfactorsthatregulatesarscov2entry AT xinxinhuang agenomewidecrisprscreenidentifieshostfactorsthatregulatesarscov2entry AT hongjunchen agenomewidecrisprscreenidentifieshostfactorsthatregulatesarscov2entry AT weixu agenomewidecrisprscreenidentifieshostfactorsthatregulatesarscov2entry AT youhuaxie agenomewidecrisprscreenidentifieshostfactorsthatregulatesarscov2entry AT qiliangcai agenomewidecrisprscreenidentifieshostfactorsthatregulatesarscov2entry AT zhenghongyuan agenomewidecrisprscreenidentifieshostfactorsthatregulatesarscov2entry AT rongzhang agenomewidecrisprscreenidentifieshostfactorsthatregulatesarscov2entry AT yunkaizhu genomewidecrisprscreenidentifieshostfactorsthatregulatesarscov2entry AT feifeng genomewidecrisprscreenidentifieshostfactorsthatregulatesarscov2entry AT gaoweihu genomewidecrisprscreenidentifieshostfactorsthatregulatesarscov2entry AT yuyanwang genomewidecrisprscreenidentifieshostfactorsthatregulatesarscov2entry AT yinyu genomewidecrisprscreenidentifieshostfactorsthatregulatesarscov2entry AT yuanfeizhu genomewidecrisprscreenidentifieshostfactorsthatregulatesarscov2entry AT weixu genomewidecrisprscreenidentifieshostfactorsthatregulatesarscov2entry AT xiacai genomewidecrisprscreenidentifieshostfactorsthatregulatesarscov2entry AT zhipingsun genomewidecrisprscreenidentifieshostfactorsthatregulatesarscov2entry AT wendonghan genomewidecrisprscreenidentifieshostfactorsthatregulatesarscov2entry AT rongye genomewidecrisprscreenidentifieshostfactorsthatregulatesarscov2entry AT diqu genomewidecrisprscreenidentifieshostfactorsthatregulatesarscov2entry AT qiangding genomewidecrisprscreenidentifieshostfactorsthatregulatesarscov2entry AT xinxinhuang genomewidecrisprscreenidentifieshostfactorsthatregulatesarscov2entry AT hongjunchen genomewidecrisprscreenidentifieshostfactorsthatregulatesarscov2entry AT weixu genomewidecrisprscreenidentifieshostfactorsthatregulatesarscov2entry AT youhuaxie genomewidecrisprscreenidentifieshostfactorsthatregulatesarscov2entry AT qiliangcai genomewidecrisprscreenidentifieshostfactorsthatregulatesarscov2entry AT zhenghongyuan genomewidecrisprscreenidentifieshostfactorsthatregulatesarscov2entry AT rongzhang genomewidecrisprscreenidentifieshostfactorsthatregulatesarscov2entry |
| _version_ |
1718391844051615744 |