A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry

A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry

The SARS-CoV-2 spike protein contains a multi-basic cleavage site. Here, the authors show how this multi-basic cleavage site affects entry of SARS-CoV-2 into cells and transmission in the hamster model and identify host factors affecting entry of SARS-CoV-2 in a genome-wide CRISPR screen.

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Bibliographic Details
Main Authors: Yunkai Zhu, Fei Feng, Gaowei Hu, Yuyan Wang, Yin Yu, Yuanfei Zhu, Wei Xu, Xia Cai, Zhiping Sun, Wendong Han, Rong Ye, Di Qu, Qiang Ding, Xinxin Huang, Hongjun Chen, Youhua Xie, Qiliang Cai, Zhenghong Yuan, Rong Zhang
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Science
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Online Access:https://doaj.org/article/614198775ef44e57a0a5f7bb249a104c
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