Hyaluronic acid-functionalized bismuth oxide nanoparticles for computed tomography imaging-guided radiotherapy of tumor

Fengyi Du,1,2,* Jiaming Lou,1,* Rong Jiang,2,* Zhengzou Fang,2,* Xuefen Zhao,2 Yuanyuan Niu,2 Shenqiang Zou,3 Miaomiao Zhang,2 Aihua Gong,2 Chaoyang Wu1 1Department of Oncology, The Affiliated People’s Hospital, Jiangsu University, Zhenjiang, People’s Republic of China; 2Departm...

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Autores principales:	Du FY, Lou JM, Jiang R, Fang ZZ, Zhao XF, Niu YY, Zou SQ, Zhang MM, Gong AH, Wu CY
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	HA-Bi2O3 NPs CT imaging Radiosensitivity HA Bismuth. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6141c021d1784622ab15d91b1c27cd67
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spelling	oai:doaj.org-article:6141c021d1784622ab15d91b1c27cd672021-12-02T06:31:49ZHyaluronic acid-functionalized bismuth oxide nanoparticles for computed tomography imaging-guided radiotherapy of tumor1178-2013https://doaj.org/article/6141c021d1784622ab15d91b1c27cd672017-08-01T00:00:00Zhttps://www.dovepress.com/hyaluronic-acid-functionalized-bismuth-oxide-nanoparticles-for-compute-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Fengyi Du,1,2,* Jiaming Lou,1,* Rong Jiang,2,* Zhengzou Fang,2,* Xuefen Zhao,2 Yuanyuan Niu,2 Shenqiang Zou,3 Miaomiao Zhang,2 Aihua Gong,2 Chaoyang Wu1 1Department of Oncology, The Affiliated People’s Hospital, Jiangsu University, Zhenjiang, People’s Republic of China; 2Department of Cellular Biology, School of Medicine, Jiangsu University, Zhenjiang, People’s Republic of China; 3Department of Hepatosis, The Third Hospital of Zhenjiang Affiliated, Jiangsu University, Zhenjiang, People’s Republic of China *These authors contributed equally to this work Abstract: The inherent radioresistance and inaccuracy of localization of tumors weaken the clinical implementation effectiveness of radiotherapy. To overcome these limitations, hyaluronic acid-functionalized bismuth oxide nanoparticles (HA-Bi2O3 NPs) were synthesized by one-pot hydrothermal method for target-specific computed tomography (CT) imaging and radiosensitization of tumor. After functionalization with hyaluronic acid, the Bi2O3 NPs possessed favorable solubility in water and excellent biocompatibility and were uptaken specifically by cancer cells overexpressing CD44 receptors. The as-prepared HA-Bi2O3 NPs exhibited high X-ray attenuation efficiency and ideal radiosensitivity via synergizing X-rays to induce cell apoptosis and arrest the cell cycle in a dose-dependent manner in vitro. Remarkably, these properties offered excellent performance in active-targeting CT imaging and enhancement of radiosensitivity for inhibition of tumor growth. These findings demonstrated that HA-Bi2O3 NPs as theranostic agents exhibit great promise for CT imaging-guided radiotherapy in diagnosis and treatment of tumors. Keywords: HA-Bi2O3 NPs, CT imaging, radiosensitivity, HA, bismuthDu FYLou JMJiang RFang ZZZhao XFNiu YYZou SQZhang MMGong AHWu CYDove Medical PressarticleHA-Bi2O3 NPsCT imagingRadiosensitivityHABismuth.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 5973-5992 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	HA-Bi2O3 NPs CT imaging Radiosensitivity HA Bismuth. Medicine (General) R5-920
spellingShingle	HA-Bi2O3 NPs CT imaging Radiosensitivity HA Bismuth. Medicine (General) R5-920 Du FY Lou JM Jiang R Fang ZZ Zhao XF Niu YY Zou SQ Zhang MM Gong AH Wu CY Hyaluronic acid-functionalized bismuth oxide nanoparticles for computed tomography imaging-guided radiotherapy of tumor
description	Fengyi Du,1,2,* Jiaming Lou,1,* Rong Jiang,2,* Zhengzou Fang,2,* Xuefen Zhao,2 Yuanyuan Niu,2 Shenqiang Zou,3 Miaomiao Zhang,2 Aihua Gong,2 Chaoyang Wu1 1Department of Oncology, The Affiliated People’s Hospital, Jiangsu University, Zhenjiang, People’s Republic of China; 2Department of Cellular Biology, School of Medicine, Jiangsu University, Zhenjiang, People’s Republic of China; 3Department of Hepatosis, The Third Hospital of Zhenjiang Affiliated, Jiangsu University, Zhenjiang, People’s Republic of China *These authors contributed equally to this work Abstract: The inherent radioresistance and inaccuracy of localization of tumors weaken the clinical implementation effectiveness of radiotherapy. To overcome these limitations, hyaluronic acid-functionalized bismuth oxide nanoparticles (HA-Bi2O3 NPs) were synthesized by one-pot hydrothermal method for target-specific computed tomography (CT) imaging and radiosensitization of tumor. After functionalization with hyaluronic acid, the Bi2O3 NPs possessed favorable solubility in water and excellent biocompatibility and were uptaken specifically by cancer cells overexpressing CD44 receptors. The as-prepared HA-Bi2O3 NPs exhibited high X-ray attenuation efficiency and ideal radiosensitivity via synergizing X-rays to induce cell apoptosis and arrest the cell cycle in a dose-dependent manner in vitro. Remarkably, these properties offered excellent performance in active-targeting CT imaging and enhancement of radiosensitivity for inhibition of tumor growth. These findings demonstrated that HA-Bi2O3 NPs as theranostic agents exhibit great promise for CT imaging-guided radiotherapy in diagnosis and treatment of tumors. Keywords: HA-Bi2O3 NPs, CT imaging, radiosensitivity, HA, bismuth
format	article
author	Du FY Lou JM Jiang R Fang ZZ Zhao XF Niu YY Zou SQ Zhang MM Gong AH Wu CY
author_facet	Du FY Lou JM Jiang R Fang ZZ Zhao XF Niu YY Zou SQ Zhang MM Gong AH Wu CY
author_sort	Du FY
title	Hyaluronic acid-functionalized bismuth oxide nanoparticles for computed tomography imaging-guided radiotherapy of tumor
title_short	Hyaluronic acid-functionalized bismuth oxide nanoparticles for computed tomography imaging-guided radiotherapy of tumor
title_full	Hyaluronic acid-functionalized bismuth oxide nanoparticles for computed tomography imaging-guided radiotherapy of tumor
title_fullStr	Hyaluronic acid-functionalized bismuth oxide nanoparticles for computed tomography imaging-guided radiotherapy of tumor
title_full_unstemmed	Hyaluronic acid-functionalized bismuth oxide nanoparticles for computed tomography imaging-guided radiotherapy of tumor
title_sort	hyaluronic acid-functionalized bismuth oxide nanoparticles for computed tomography imaging-guided radiotherapy of tumor
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/6141c021d1784622ab15d91b1c27cd67
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Hyaluronic acid-functionalized bismuth oxide nanoparticles for computed tomography imaging-guided radiotherapy of tumor

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