Cdk1-mediated DIAPH1 phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase

Cell rounding at mitosis is driven by cortical tension and maintained through metaphase, although the mechanism is unknown. Here, the authors demonstrate that Cdk1 phosphorylation of DIAPH1 is required for both cortical tension maintenance and inactivation of the spindle assembly checkpoint.

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Autores principales:	Koutarou Nishimura, Yoshikazu Johmura, Katashi Deguchi, Zixian Jiang, Kazuhiko S. K. Uchida, Narumi Suzuki, Midori Shimada, Yoshie Chiba, Toru Hirota, Shige H. Yoshimura, Keiko Kono, Makoto Nakanishi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/61424f56c6b6498db1f4dcbad44bf4dc
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spelling	oai:doaj.org-article:61424f56c6b6498db1f4dcbad44bf4dc2021-12-02T15:36:04ZCdk1-mediated DIAPH1 phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase10.1038/s41467-019-08957-w2041-1723https://doaj.org/article/61424f56c6b6498db1f4dcbad44bf4dc2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08957-whttps://doaj.org/toc/2041-1723Cell rounding at mitosis is driven by cortical tension and maintained through metaphase, although the mechanism is unknown. Here, the authors demonstrate that Cdk1 phosphorylation of DIAPH1 is required for both cortical tension maintenance and inactivation of the spindle assembly checkpoint.Koutarou NishimuraYoshikazu JohmuraKatashi DeguchiZixian JiangKazuhiko S. K. UchidaNarumi SuzukiMidori ShimadaYoshie ChibaToru HirotaShige H. YoshimuraKeiko KonoMakoto NakanishiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Koutarou Nishimura Yoshikazu Johmura Katashi Deguchi Zixian Jiang Kazuhiko S. K. Uchida Narumi Suzuki Midori Shimada Yoshie Chiba Toru Hirota Shige H. Yoshimura Keiko Kono Makoto Nakanishi Cdk1-mediated DIAPH1 phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase
description	Cell rounding at mitosis is driven by cortical tension and maintained through metaphase, although the mechanism is unknown. Here, the authors demonstrate that Cdk1 phosphorylation of DIAPH1 is required for both cortical tension maintenance and inactivation of the spindle assembly checkpoint.
format	article
author	Koutarou Nishimura Yoshikazu Johmura Katashi Deguchi Zixian Jiang Kazuhiko S. K. Uchida Narumi Suzuki Midori Shimada Yoshie Chiba Toru Hirota Shige H. Yoshimura Keiko Kono Makoto Nakanishi
author_facet	Koutarou Nishimura Yoshikazu Johmura Katashi Deguchi Zixian Jiang Kazuhiko S. K. Uchida Narumi Suzuki Midori Shimada Yoshie Chiba Toru Hirota Shige H. Yoshimura Keiko Kono Makoto Nakanishi
author_sort	Koutarou Nishimura
title	Cdk1-mediated DIAPH1 phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase
title_short	Cdk1-mediated DIAPH1 phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase
title_full	Cdk1-mediated DIAPH1 phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase
title_fullStr	Cdk1-mediated DIAPH1 phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase
title_full_unstemmed	Cdk1-mediated DIAPH1 phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase
title_sort	cdk1-mediated diaph1 phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/61424f56c6b6498db1f4dcbad44bf4dc
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Cdk1-mediated DIAPH1 phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase

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