Cdk1-mediated DIAPH1 phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase

Cdk1-mediated DIAPH1 phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase

Cell rounding at mitosis is driven by cortical tension and maintained through metaphase, although the mechanism is unknown. Here, the authors demonstrate that Cdk1 phosphorylation of DIAPH1 is required for both cortical tension maintenance and inactivation of the spindle assembly checkpoint.

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Autores principales: Koutarou Nishimura, Yoshikazu Johmura, Katashi Deguchi, Zixian Jiang, Kazuhiko S. K. Uchida, Narumi Suzuki, Midori Shimada, Yoshie Chiba, Toru Hirota, Shige H. Yoshimura, Keiko Kono, Makoto Nakanishi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/61424f56c6b6498db1f4dcbad44bf4dc
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