Cryo-EM structure of the human ferritin–transferrin receptor 1 complex

The human transferrin receptor 1 (CD71) is a transmembrane protein responsible for iron uptake. Here the authors present the 3.9 Å resolution cryo-EM structure of the CD71 ectodomain-human ferritin (H-Ft) complex and find that H-Ft binds a CD71 region different from the transferrin one that overlaps...

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Autores principales:	Linda Celeste Montemiglio, Claudia Testi, Pierpaolo Ceci, Elisabetta Falvo, Martina Pitea, Carmelinda Savino, Alessandro Arcovito, Giovanna Peruzzi, Paola Baiocco, Filippo Mancia, Alberto Boffi, Amédée des Georges, Beatrice Vallone
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/61472d52cca641faa05071392f71cf5c
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spelling	oai:doaj.org-article:61472d52cca641faa05071392f71cf5c2021-12-02T16:57:55ZCryo-EM structure of the human ferritin–transferrin receptor 1 complex10.1038/s41467-019-09098-w2041-1723https://doaj.org/article/61472d52cca641faa05071392f71cf5c2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09098-whttps://doaj.org/toc/2041-1723The human transferrin receptor 1 (CD71) is a transmembrane protein responsible for iron uptake. Here the authors present the 3.9 Å resolution cryo-EM structure of the CD71 ectodomain-human ferritin (H-Ft) complex and find that H-Ft binds a CD71 region different from the transferrin one that overlaps with the surface recognized by select pathogens.Linda Celeste MontemiglioClaudia TestiPierpaolo CeciElisabetta FalvoMartina PiteaCarmelinda SavinoAlessandro ArcovitoGiovanna PeruzziPaola BaioccoFilippo ManciaAlberto BoffiAmédée des GeorgesBeatrice ValloneNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Linda Celeste Montemiglio Claudia Testi Pierpaolo Ceci Elisabetta Falvo Martina Pitea Carmelinda Savino Alessandro Arcovito Giovanna Peruzzi Paola Baiocco Filippo Mancia Alberto Boffi Amédée des Georges Beatrice Vallone Cryo-EM structure of the human ferritin–transferrin receptor 1 complex
description	The human transferrin receptor 1 (CD71) is a transmembrane protein responsible for iron uptake. Here the authors present the 3.9 Å resolution cryo-EM structure of the CD71 ectodomain-human ferritin (H-Ft) complex and find that H-Ft binds a CD71 region different from the transferrin one that overlaps with the surface recognized by select pathogens.
format	article
author	Linda Celeste Montemiglio Claudia Testi Pierpaolo Ceci Elisabetta Falvo Martina Pitea Carmelinda Savino Alessandro Arcovito Giovanna Peruzzi Paola Baiocco Filippo Mancia Alberto Boffi Amédée des Georges Beatrice Vallone
author_facet	Linda Celeste Montemiglio Claudia Testi Pierpaolo Ceci Elisabetta Falvo Martina Pitea Carmelinda Savino Alessandro Arcovito Giovanna Peruzzi Paola Baiocco Filippo Mancia Alberto Boffi Amédée des Georges Beatrice Vallone
author_sort	Linda Celeste Montemiglio
title	Cryo-EM structure of the human ferritin–transferrin receptor 1 complex
title_short	Cryo-EM structure of the human ferritin–transferrin receptor 1 complex
title_full	Cryo-EM structure of the human ferritin–transferrin receptor 1 complex
title_fullStr	Cryo-EM structure of the human ferritin–transferrin receptor 1 complex
title_full_unstemmed	Cryo-EM structure of the human ferritin–transferrin receptor 1 complex
title_sort	cryo-em structure of the human ferritin–transferrin receptor 1 complex
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/61472d52cca641faa05071392f71cf5c
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Cryo-EM structure of the human ferritin–transferrin receptor 1 complex

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