Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism
Mice deficient in the pro-inflammatory cytokine IFNγ have improved glucose tolerance. Here, the authors show that this effect depends on the gut microbeAkkermansia muciniphila, whose abundance increases in the absence IFNγ, and which is known to have beneficial effects on host metabolism.
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Nature Portfolio
2016
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oai:doaj.org-article:61494a965e404846a44ae00fc93376f42021-12-02T17:32:36ZAkkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism10.1038/ncomms133292041-1723https://doaj.org/article/61494a965e404846a44ae00fc93376f42016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13329https://doaj.org/toc/2041-1723Mice deficient in the pro-inflammatory cytokine IFNγ have improved glucose tolerance. Here, the authors show that this effect depends on the gut microbeAkkermansia muciniphila, whose abundance increases in the absence IFNγ, and which is known to have beneficial effects on host metabolism.Renee L. GreerXiaoxi DongAna Carolina F. MoraesRyszard A. ZielkeGabriel R. FernandesEkaterina PeremyslovaStephany Vasquez-PerezAlexi A. SchoenbornEverton P. GomesAlexandre C. PereiraSandra R. G. FerreiraMichael YaoIvan J. FussWarren StroberAleksandra E. SikoraGregory A. TaylorAjay S. GulatiAndrey MorgunNatalia ShulzhenkoNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Renee L. Greer Xiaoxi Dong Ana Carolina F. Moraes Ryszard A. Zielke Gabriel R. Fernandes Ekaterina Peremyslova Stephany Vasquez-Perez Alexi A. Schoenborn Everton P. Gomes Alexandre C. Pereira Sandra R. G. Ferreira Michael Yao Ivan J. Fuss Warren Strober Aleksandra E. Sikora Gregory A. Taylor Ajay S. Gulati Andrey Morgun Natalia Shulzhenko Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism |
| description |
Mice deficient in the pro-inflammatory cytokine IFNγ have improved glucose tolerance. Here, the authors show that this effect depends on the gut microbeAkkermansia muciniphila, whose abundance increases in the absence IFNγ, and which is known to have beneficial effects on host metabolism. |
| format |
article |
| author |
Renee L. Greer Xiaoxi Dong Ana Carolina F. Moraes Ryszard A. Zielke Gabriel R. Fernandes Ekaterina Peremyslova Stephany Vasquez-Perez Alexi A. Schoenborn Everton P. Gomes Alexandre C. Pereira Sandra R. G. Ferreira Michael Yao Ivan J. Fuss Warren Strober Aleksandra E. Sikora Gregory A. Taylor Ajay S. Gulati Andrey Morgun Natalia Shulzhenko |
| author_facet |
Renee L. Greer Xiaoxi Dong Ana Carolina F. Moraes Ryszard A. Zielke Gabriel R. Fernandes Ekaterina Peremyslova Stephany Vasquez-Perez Alexi A. Schoenborn Everton P. Gomes Alexandre C. Pereira Sandra R. G. Ferreira Michael Yao Ivan J. Fuss Warren Strober Aleksandra E. Sikora Gregory A. Taylor Ajay S. Gulati Andrey Morgun Natalia Shulzhenko |
| author_sort |
Renee L. Greer |
| title |
Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism |
| title_short |
Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism |
| title_full |
Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism |
| title_fullStr |
Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism |
| title_full_unstemmed |
Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism |
| title_sort |
akkermansia muciniphila mediates negative effects of ifnγ on glucose metabolism |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/61494a965e404846a44ae00fc93376f4 |
| work_keys_str_mv |
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