Altered miRNA expression network in locus coeruleus of depressed suicide subjects

Abstract Norepinephrine (NE) is produced primarily by neurons in the locus coeruleus (LC). Retrograde and ultrastructural examinations reveal that the core of the LC and its surrounding region receives afferent projections from several brain areas which provide multiple neurochemical inputs to the L...

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Autores principales:	Bhaskar Roy, Qingzhong Wang, Miklos Palkovits, Gabor Faludi, Yogesh Dwivedi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/614cdfdafa5241c4b566e87b733cf11c
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spelling	oai:doaj.org-article:614cdfdafa5241c4b566e87b733cf11c2021-12-02T15:06:22ZAltered miRNA expression network in locus coeruleus of depressed suicide subjects10.1038/s41598-017-04300-92045-2322https://doaj.org/article/614cdfdafa5241c4b566e87b733cf11c2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04300-9https://doaj.org/toc/2045-2322Abstract Norepinephrine (NE) is produced primarily by neurons in the locus coeruleus (LC). Retrograde and ultrastructural examinations reveal that the core of the LC and its surrounding region receives afferent projections from several brain areas which provide multiple neurochemical inputs to the LC with changes in LC neuronal firing, making it a highly coordinated event. Although NE and mediated signaling systems have been studied in relation to suicide and psychiatric disorders that increase the risk of suicide including depression, less is known about the corresponding changes in molecular network within LC. In this study, we examined miRNA networks in the LC of depressed suicide completers and healthy controls. Expression array revealed differential regulation of 13 miRNAs. Interaction between altered miRNAs and target genes showed dense interconnected molecular network. Functional clustering of predicated target genes yielded stress induced disorders that collectively showed the complex nature of suicidal behavior. In addition, 25 miRNAs were pairwise correlated specifically in the depressed suicide group, but not in the control group. Altogether, our study revealed for the first time the involvement of LC based dysregulated miRNA network in disrupting cellular pathways associated with suicidal behavior.Bhaskar RoyQingzhong WangMiklos PalkovitsGabor FaludiYogesh DwivediNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bhaskar Roy Qingzhong Wang Miklos Palkovits Gabor Faludi Yogesh Dwivedi Altered miRNA expression network in locus coeruleus of depressed suicide subjects
description	Abstract Norepinephrine (NE) is produced primarily by neurons in the locus coeruleus (LC). Retrograde and ultrastructural examinations reveal that the core of the LC and its surrounding region receives afferent projections from several brain areas which provide multiple neurochemical inputs to the LC with changes in LC neuronal firing, making it a highly coordinated event. Although NE and mediated signaling systems have been studied in relation to suicide and psychiatric disorders that increase the risk of suicide including depression, less is known about the corresponding changes in molecular network within LC. In this study, we examined miRNA networks in the LC of depressed suicide completers and healthy controls. Expression array revealed differential regulation of 13 miRNAs. Interaction between altered miRNAs and target genes showed dense interconnected molecular network. Functional clustering of predicated target genes yielded stress induced disorders that collectively showed the complex nature of suicidal behavior. In addition, 25 miRNAs were pairwise correlated specifically in the depressed suicide group, but not in the control group. Altogether, our study revealed for the first time the involvement of LC based dysregulated miRNA network in disrupting cellular pathways associated with suicidal behavior.
format	article
author	Bhaskar Roy Qingzhong Wang Miklos Palkovits Gabor Faludi Yogesh Dwivedi
author_facet	Bhaskar Roy Qingzhong Wang Miklos Palkovits Gabor Faludi Yogesh Dwivedi
author_sort	Bhaskar Roy
title	Altered miRNA expression network in locus coeruleus of depressed suicide subjects
title_short	Altered miRNA expression network in locus coeruleus of depressed suicide subjects
title_full	Altered miRNA expression network in locus coeruleus of depressed suicide subjects
title_fullStr	Altered miRNA expression network in locus coeruleus of depressed suicide subjects
title_full_unstemmed	Altered miRNA expression network in locus coeruleus of depressed suicide subjects
title_sort	altered mirna expression network in locus coeruleus of depressed suicide subjects
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/614cdfdafa5241c4b566e87b733cf11c
work_keys_str_mv	AT bhaskarroy alteredmirnaexpressionnetworkinlocuscoeruleusofdepressedsuicidesubjects AT qingzhongwang alteredmirnaexpressionnetworkinlocuscoeruleusofdepressedsuicidesubjects AT miklospalkovits alteredmirnaexpressionnetworkinlocuscoeruleusofdepressedsuicidesubjects AT gaborfaludi alteredmirnaexpressionnetworkinlocuscoeruleusofdepressedsuicidesubjects AT yogeshdwivedi alteredmirnaexpressionnetworkinlocuscoeruleusofdepressedsuicidesubjects
_version_	1718388452477632512

Altered miRNA expression network in locus coeruleus of depressed suicide subjects

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