Longitudinal evolution of non-motor symptoms in early Parkinson’s disease: a 3-year prospective cohort study

Abstract The progression of global non-motor symptoms (NMS) in Chinese patients with Parkinson’s disease (PD) has not been explored. We aimed to examine the longitudinal evolution of overall NMS in a 3-year prospective Chinese cohort with early-stage PD. We included 224 patients with early PD who un...

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Autores principales:	Ruwei Ou, Yanbing Hou, Qianqian Wei, Junyu Lin, Kuncheng Liu, Lingyu Zhang, Zheng Jiang, Bei Cao, Bi Zhao, Wei Song, Huifang Shang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/614d1959f0e44b9589da40be57d32e18
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spelling	oai:doaj.org-article:614d1959f0e44b9589da40be57d32e182021-12-02T18:37:04ZLongitudinal evolution of non-motor symptoms in early Parkinson’s disease: a 3-year prospective cohort study10.1038/s41531-021-00207-52373-8057https://doaj.org/article/614d1959f0e44b9589da40be57d32e182021-07-01T00:00:00Zhttps://doi.org/10.1038/s41531-021-00207-5https://doaj.org/toc/2373-8057Abstract The progression of global non-motor symptoms (NMS) in Chinese patients with Parkinson’s disease (PD) has not been explored. We aimed to examine the longitudinal evolution of overall NMS in a 3-year prospective Chinese cohort with early-stage PD. We included 224 patients with early PD who underwent annual evaluation of motor and non-motor symptoms. NMS was assessed using the non-motor symptoms scale (NMSS). We observed an increased number of NMS in the majority of the NMSS domains except mood/apathy and sexual dysfunctions. Significant deterioration was observed in the sleep/fatigue, perceptual problems/hallucinations, attention/memory, gastrointestinal, urinary, and miscellaneous domains during the follow-up (P < 0.05). Notably, the number and the score of sexual dysfunctions decreased with the progression of the disease. All NMSS domains showed a small effect size from baseline to 1-, 2-, and 3-year follow-ups (effect size < 0.5). The generalized estimating equations model indicated that the total number of NMS was significantly associated with age and the Unified Parkinson’s Disease Rating Scale (UPDRS) III score (P < 0.05). Multiple logistic regression indicated that a high number of NMS at baseline was associated with a 3-point, a 6-point, and a 9-point increase in the UPDRS III score from baseline to 1-year (odds ratio [OR] 1.074, P = 0.017), 2-year (OR 1.113, P = 0.001), and 3-year (OR 1.117, P < 0.001), respectively. Our study indicated that overall NMS evolution in early PD is mild and multidimensional; a high NMS burden in early PD predicts the faster motor progression of PD. Our study is helpful for understanding the longitudinal evolution of NMS in PD.Ruwei OuYanbing HouQianqian WeiJunyu LinKuncheng LiuLingyu ZhangZheng JiangBei CaoBi ZhaoWei SongHuifang ShangNature PortfolioarticleNeurology. Diseases of the nervous systemRC346-429ENnpj Parkinson's Disease, Vol 7, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurology. Diseases of the nervous system RC346-429 Ruwei Ou Yanbing Hou Qianqian Wei Junyu Lin Kuncheng Liu Lingyu Zhang Zheng Jiang Bei Cao Bi Zhao Wei Song Huifang Shang Longitudinal evolution of non-motor symptoms in early Parkinson’s disease: a 3-year prospective cohort study
description	Abstract The progression of global non-motor symptoms (NMS) in Chinese patients with Parkinson’s disease (PD) has not been explored. We aimed to examine the longitudinal evolution of overall NMS in a 3-year prospective Chinese cohort with early-stage PD. We included 224 patients with early PD who underwent annual evaluation of motor and non-motor symptoms. NMS was assessed using the non-motor symptoms scale (NMSS). We observed an increased number of NMS in the majority of the NMSS domains except mood/apathy and sexual dysfunctions. Significant deterioration was observed in the sleep/fatigue, perceptual problems/hallucinations, attention/memory, gastrointestinal, urinary, and miscellaneous domains during the follow-up (P < 0.05). Notably, the number and the score of sexual dysfunctions decreased with the progression of the disease. All NMSS domains showed a small effect size from baseline to 1-, 2-, and 3-year follow-ups (effect size < 0.5). The generalized estimating equations model indicated that the total number of NMS was significantly associated with age and the Unified Parkinson’s Disease Rating Scale (UPDRS) III score (P < 0.05). Multiple logistic regression indicated that a high number of NMS at baseline was associated with a 3-point, a 6-point, and a 9-point increase in the UPDRS III score from baseline to 1-year (odds ratio [OR] 1.074, P = 0.017), 2-year (OR 1.113, P = 0.001), and 3-year (OR 1.117, P < 0.001), respectively. Our study indicated that overall NMS evolution in early PD is mild and multidimensional; a high NMS burden in early PD predicts the faster motor progression of PD. Our study is helpful for understanding the longitudinal evolution of NMS in PD.
format	article
author	Ruwei Ou Yanbing Hou Qianqian Wei Junyu Lin Kuncheng Liu Lingyu Zhang Zheng Jiang Bei Cao Bi Zhao Wei Song Huifang Shang
author_facet	Ruwei Ou Yanbing Hou Qianqian Wei Junyu Lin Kuncheng Liu Lingyu Zhang Zheng Jiang Bei Cao Bi Zhao Wei Song Huifang Shang
author_sort	Ruwei Ou
title	Longitudinal evolution of non-motor symptoms in early Parkinson’s disease: a 3-year prospective cohort study
title_short	Longitudinal evolution of non-motor symptoms in early Parkinson’s disease: a 3-year prospective cohort study
title_full	Longitudinal evolution of non-motor symptoms in early Parkinson’s disease: a 3-year prospective cohort study
title_fullStr	Longitudinal evolution of non-motor symptoms in early Parkinson’s disease: a 3-year prospective cohort study
title_full_unstemmed	Longitudinal evolution of non-motor symptoms in early Parkinson’s disease: a 3-year prospective cohort study
title_sort	longitudinal evolution of non-motor symptoms in early parkinson’s disease: a 3-year prospective cohort study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/614d1959f0e44b9589da40be57d32e18
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Longitudinal evolution of non-motor symptoms in early Parkinson’s disease: a 3-year prospective cohort study

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