Spacetime in the brain: rapid brain network reorganization in visual processing and recovery

Abstract Functional connectivity networks (FCN) are the physiological basis of brain synchronization to integrating neural activity. They are not rigid but can reorganize under pathological conditions or during mental or behavioral states. However, because mental acts can be very fast, like the blin...

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Autores principales:	Zheng Wu, Bernhard A. Sabel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/614fea0b43a24b14a1b6c492ee9b562e
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spelling	oai:doaj.org-article:614fea0b43a24b14a1b6c492ee9b562e2021-12-02T14:58:48ZSpacetime in the brain: rapid brain network reorganization in visual processing and recovery10.1038/s41598-021-96971-82045-2322https://doaj.org/article/614fea0b43a24b14a1b6c492ee9b562e2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96971-8https://doaj.org/toc/2045-2322Abstract Functional connectivity networks (FCN) are the physiological basis of brain synchronization to integrating neural activity. They are not rigid but can reorganize under pathological conditions or during mental or behavioral states. However, because mental acts can be very fast, like the blink of an eye, we now used the visual system as a model to explore rapid FCN reorganization and its functional impact in normal, abnormal and post treatment vision. EEG-recordings were time-locked to visual stimulus presentation; graph analysis of neurophysiological oscillations were used to characterize millisecond FCN dynamics in healthy subjects and in patients with optic nerve damage before and after neuromodulation with alternating currents stimulation and were correlated with visual performance. We showed that rapid and transient FCN synchronization patterns in humans can evolve and dissolve in millisecond speed during visual processing. This rapid FCN reorganization is functionally relevant because disruption and recovery after treatment in optic nerve patients correlated with impaired and recovered visual performance, respectively. Because FCN hub and node interactions can evolve and dissolve in millisecond speed to manage spatial and temporal neural synchronization during visual processing and recovery, we propose “Brain Spacetime” as a fundamental principle of the human mind not only in visual cognition but also in vision restoration.Zheng WuBernhard A. SabelNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zheng Wu Bernhard A. Sabel Spacetime in the brain: rapid brain network reorganization in visual processing and recovery
description	Abstract Functional connectivity networks (FCN) are the physiological basis of brain synchronization to integrating neural activity. They are not rigid but can reorganize under pathological conditions or during mental or behavioral states. However, because mental acts can be very fast, like the blink of an eye, we now used the visual system as a model to explore rapid FCN reorganization and its functional impact in normal, abnormal and post treatment vision. EEG-recordings were time-locked to visual stimulus presentation; graph analysis of neurophysiological oscillations were used to characterize millisecond FCN dynamics in healthy subjects and in patients with optic nerve damage before and after neuromodulation with alternating currents stimulation and were correlated with visual performance. We showed that rapid and transient FCN synchronization patterns in humans can evolve and dissolve in millisecond speed during visual processing. This rapid FCN reorganization is functionally relevant because disruption and recovery after treatment in optic nerve patients correlated with impaired and recovered visual performance, respectively. Because FCN hub and node interactions can evolve and dissolve in millisecond speed to manage spatial and temporal neural synchronization during visual processing and recovery, we propose “Brain Spacetime” as a fundamental principle of the human mind not only in visual cognition but also in vision restoration.
format	article
author	Zheng Wu Bernhard A. Sabel
author_facet	Zheng Wu Bernhard A. Sabel
author_sort	Zheng Wu
title	Spacetime in the brain: rapid brain network reorganization in visual processing and recovery
title_short	Spacetime in the brain: rapid brain network reorganization in visual processing and recovery
title_full	Spacetime in the brain: rapid brain network reorganization in visual processing and recovery
title_fullStr	Spacetime in the brain: rapid brain network reorganization in visual processing and recovery
title_full_unstemmed	Spacetime in the brain: rapid brain network reorganization in visual processing and recovery
title_sort	spacetime in the brain: rapid brain network reorganization in visual processing and recovery
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/614fea0b43a24b14a1b6c492ee9b562e
work_keys_str_mv	AT zhengwu spacetimeinthebrainrapidbrainnetworkreorganizationinvisualprocessingandrecovery AT bernhardasabel spacetimeinthebrainrapidbrainnetworkreorganizationinvisualprocessingandrecovery
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Spacetime in the brain: rapid brain network reorganization in visual processing and recovery

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