The M-phase regulatory phosphatase PP2A-B55δ opposes protein kinase A on Arpp19 to initiate meiotic division

Mechanisms triggering meiotic divisions of oocytes remain unclear. Here, the authors report that meiosis resumption relies on the timely phosphorylation of Arpp19 protein at two distinct sites, which depends on two kinases (PKA and Gwl) and a single phosphatase (PP2A-B55δ).

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Autores principales:	Tom Lemonnier, Enrico Maria Daldello, Robert Poulhe, Tran Le, Marika Miot, Laurent Lignières, Catherine Jessus, Aude Dupré
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6154f13ed5fd440e8384d4ab8cff94e6
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spelling	oai:doaj.org-article:6154f13ed5fd440e8384d4ab8cff94e62021-12-02T11:44:56ZThe M-phase regulatory phosphatase PP2A-B55δ opposes protein kinase A on Arpp19 to initiate meiotic division10.1038/s41467-021-22124-02041-1723https://doaj.org/article/6154f13ed5fd440e8384d4ab8cff94e62021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22124-0https://doaj.org/toc/2041-1723Mechanisms triggering meiotic divisions of oocytes remain unclear. Here, the authors report that meiosis resumption relies on the timely phosphorylation of Arpp19 protein at two distinct sites, which depends on two kinases (PKA and Gwl) and a single phosphatase (PP2A-B55δ).Tom LemonnierEnrico Maria DaldelloRobert PoulheTran LeMarika MiotLaurent LignièresCatherine JessusAude DupréNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tom Lemonnier Enrico Maria Daldello Robert Poulhe Tran Le Marika Miot Laurent Lignières Catherine Jessus Aude Dupré The M-phase regulatory phosphatase PP2A-B55δ opposes protein kinase A on Arpp19 to initiate meiotic division
description	Mechanisms triggering meiotic divisions of oocytes remain unclear. Here, the authors report that meiosis resumption relies on the timely phosphorylation of Arpp19 protein at two distinct sites, which depends on two kinases (PKA and Gwl) and a single phosphatase (PP2A-B55δ).
format	article
author	Tom Lemonnier Enrico Maria Daldello Robert Poulhe Tran Le Marika Miot Laurent Lignières Catherine Jessus Aude Dupré
author_facet	Tom Lemonnier Enrico Maria Daldello Robert Poulhe Tran Le Marika Miot Laurent Lignières Catherine Jessus Aude Dupré
author_sort	Tom Lemonnier
title	The M-phase regulatory phosphatase PP2A-B55δ opposes protein kinase A on Arpp19 to initiate meiotic division
title_short	The M-phase regulatory phosphatase PP2A-B55δ opposes protein kinase A on Arpp19 to initiate meiotic division
title_full	The M-phase regulatory phosphatase PP2A-B55δ opposes protein kinase A on Arpp19 to initiate meiotic division
title_fullStr	The M-phase regulatory phosphatase PP2A-B55δ opposes protein kinase A on Arpp19 to initiate meiotic division
title_full_unstemmed	The M-phase regulatory phosphatase PP2A-B55δ opposes protein kinase A on Arpp19 to initiate meiotic division
title_sort	m-phase regulatory phosphatase pp2a-b55δ opposes protein kinase a on arpp19 to initiate meiotic division
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6154f13ed5fd440e8384d4ab8cff94e6
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The M-phase regulatory phosphatase PP2A-B55δ opposes protein kinase A on Arpp19 to initiate meiotic division

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