Severe Psychiatric Symptoms in a Patient With EGFR Exon-20 Insertion Mutation Receiving Mobocertinib: A Case Report

Severe Psychiatric Symptoms in a Patient With EGFR Exon-20 Insertion Mutation Receiving Mobocertinib: A Case Report

Tyrosine kinase inhibitor therapy is an established standard of care for patients with NSCLC with EGFR mutations, but a worse prognosis has been observed in patients with specific EGFR exon-20 insertion mutations. Mobocertinib (TAK-788) is a novel tyrosine kinase inhibitor developed to target EGFR e...

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Bibliographic Details
Main Authors: Josette Kamel, BA, Natalie Meeder, BA, Sandra Cuellar, PharmD, BCOP, David Chan, PharmD, PhD, Michael Huber, MD, MS, Mary Pasquinelli, DNP, Alicia Hulbert, MD, Karam Khaddour, MD, Lawrence Feldman, MD
Format: article
Language:EN
Published: Elsevier 2021
Subjects:
Tyrosine kinase inhibitors
Non–small cell lung cancer
Exon-20 insertion
Mobocertinib
CNS neurotoxicity
Case report
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Online Access:https://doaj.org/article/61551415e3464b25acbfc6de48caa7de
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