Genetic Variation in <i>ABCC4</i> and <i>CFTR</i> and Acute Pancreatitis during Treatment of Pediatric Acute Lymphoblastic Leukemia

Genetic Variation in <i>ABCC4</i> and <i>CFTR</i> and Acute Pancreatitis during Treatment of Pediatric Acute Lymphoblastic Leukemia

Background: Acute pancreatitis (AP) is a serious, mechanistically not entirely resolved side effect of L-asparaginase-containing treatment for acute lymphoblastic leukemia (ALL). To find new candidate variations for AP, we conducted a genome-wide association study (GWAS). Methods: In all, 1,004,623...

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Auteurs principaux: Thies Bartram, Peter Schütte, Anja Möricke, Richard S. Houlston, Eva Ellinghaus, Martin Zimmermann, Anke Bergmann, Britt-Sabina Löscher, Norman Klein, Laura Hinze, Stefanie V. Junk, Michael Forster, Claus R. Bartram, Rolf Köhler, Andre Franke, Martin Schrappe, Christian P. Kratz, Gunnar Cario, Martin Stanulla
Format: article
Langue:EN
Publié: MDPI AG 2021
Sujets:
acute lymphoblastic leukemia
L-asparaginase
acute pancreatitis
polymorphism
SNV
<i>ABCC4</i>
Medicine
R
Accès en ligne:https://doaj.org/article/615d53304ff54ea3b6b7addc071c6c17
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https://doaj.org/article/615d53304ff54ea3b6b7addc071c6c17

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