The Effects of Ionising and Non-Ionising Electromagnetic Radiation on Extracellular Matrix Proteins

Exposure to sub-lethal doses of ionising and non-ionising electromagnetic radiation can impact human health and well-being as a consequence of, for example, the side effects of radiotherapy (therapeutic X-ray exposure) and accelerated skin ageing (chronic exposure to ultraviolet radiation: UVR). Whi...

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Autores principales:	Ren Jie Tuieng, Sarah H. Cartmell, Cliona C. Kirwan, Michael J. Sherratt
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	ionising radiation X-rays ultraviolet (UV) radiation extracellular matrix (ECM) skin breast Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/6162050becc14a348cd2dc297711424f
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spelling	oai:doaj.org-article:6162050becc14a348cd2dc297711424f2021-11-25T17:10:41ZThe Effects of Ionising and Non-Ionising Electromagnetic Radiation on Extracellular Matrix Proteins10.3390/cells101130412073-4409https://doaj.org/article/6162050becc14a348cd2dc297711424f2021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3041https://doaj.org/toc/2073-4409Exposure to sub-lethal doses of ionising and non-ionising electromagnetic radiation can impact human health and well-being as a consequence of, for example, the side effects of radiotherapy (therapeutic X-ray exposure) and accelerated skin ageing (chronic exposure to ultraviolet radiation: UVR). Whilst attention has focused primarily on the interaction of electromagnetic radiation with cells and cellular components, radiation-induced damage to long-lived extracellular matrix (ECM) proteins has the potential to profoundly affect tissue structure, composition and function. This review focuses on the current understanding of the biological effects of ionising and non-ionising radiation on the ECM of breast stroma and skin dermis, respectively. Although there is some experimental evidence for radiation-induced damage to ECM proteins, compared with the well-characterised impact of radiation exposure on cell biology, the structural, functional, and ultimately clinical consequences of ECM irradiation remain poorly defined.Ren Jie TuiengSarah H. CartmellCliona C. KirwanMichael J. SherrattMDPI AGarticleionising radiationX-raysultraviolet (UV) radiationextracellular matrix (ECM)skinbreastBiology (General)QH301-705.5ENCells, Vol 10, Iss 3041, p 3041 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ionising radiation X-rays ultraviolet (UV) radiation extracellular matrix (ECM) skin breast Biology (General) QH301-705.5
spellingShingle	ionising radiation X-rays ultraviolet (UV) radiation extracellular matrix (ECM) skin breast Biology (General) QH301-705.5 Ren Jie Tuieng Sarah H. Cartmell Cliona C. Kirwan Michael J. Sherratt The Effects of Ionising and Non-Ionising Electromagnetic Radiation on Extracellular Matrix Proteins
description	Exposure to sub-lethal doses of ionising and non-ionising electromagnetic radiation can impact human health and well-being as a consequence of, for example, the side effects of radiotherapy (therapeutic X-ray exposure) and accelerated skin ageing (chronic exposure to ultraviolet radiation: UVR). Whilst attention has focused primarily on the interaction of electromagnetic radiation with cells and cellular components, radiation-induced damage to long-lived extracellular matrix (ECM) proteins has the potential to profoundly affect tissue structure, composition and function. This review focuses on the current understanding of the biological effects of ionising and non-ionising radiation on the ECM of breast stroma and skin dermis, respectively. Although there is some experimental evidence for radiation-induced damage to ECM proteins, compared with the well-characterised impact of radiation exposure on cell biology, the structural, functional, and ultimately clinical consequences of ECM irradiation remain poorly defined.
format	article
author	Ren Jie Tuieng Sarah H. Cartmell Cliona C. Kirwan Michael J. Sherratt
author_facet	Ren Jie Tuieng Sarah H. Cartmell Cliona C. Kirwan Michael J. Sherratt
author_sort	Ren Jie Tuieng
title	The Effects of Ionising and Non-Ionising Electromagnetic Radiation on Extracellular Matrix Proteins
title_short	The Effects of Ionising and Non-Ionising Electromagnetic Radiation on Extracellular Matrix Proteins
title_full	The Effects of Ionising and Non-Ionising Electromagnetic Radiation on Extracellular Matrix Proteins
title_fullStr	The Effects of Ionising and Non-Ionising Electromagnetic Radiation on Extracellular Matrix Proteins
title_full_unstemmed	The Effects of Ionising and Non-Ionising Electromagnetic Radiation on Extracellular Matrix Proteins
title_sort	effects of ionising and non-ionising electromagnetic radiation on extracellular matrix proteins
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6162050becc14a348cd2dc297711424f
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The Effects of Ionising and Non-Ionising Electromagnetic Radiation on Extracellular Matrix Proteins

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