Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins

Autophagy adaptors and receptors contain LC3-interacting region (LIR) motifs that bind selectively to the LIR docking site of GABARAP and other members of the ATG8 family. Here the authors show that in addition to the LIR motif also the region C-terminal of it is important for the binding specificit...

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Autores principales:	Martina Wirth, Wenxin Zhang, Minoo Razi, Lynet Nyoni, Dhira Joshi, Nicola O’Reilly, Terje Johansen, Sharon A. Tooze, Stéphane Mouilleron
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/61625672f9c642f79baf4e0b2c21a97b
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spelling	oai:doaj.org-article:61625672f9c642f79baf4e0b2c21a97b2021-12-02T17:02:09ZMolecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins10.1038/s41467-019-10059-62041-1723https://doaj.org/article/61625672f9c642f79baf4e0b2c21a97b2019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10059-6https://doaj.org/toc/2041-1723Autophagy adaptors and receptors contain LC3-interacting region (LIR) motifs that bind selectively to the LIR docking site of GABARAP and other members of the ATG8 family. Here the authors show that in addition to the LIR motif also the region C-terminal of it is important for the binding specificity of both the centriolar satellite protein PCM1 and the ULK1 complex to GABARAP subfamily proteins.Martina WirthWenxin ZhangMinoo RaziLynet NyoniDhira JoshiNicola O’ReillyTerje JohansenSharon A. ToozeStéphane MouilleronNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Martina Wirth Wenxin Zhang Minoo Razi Lynet Nyoni Dhira Joshi Nicola O’Reilly Terje Johansen Sharon A. Tooze Stéphane Mouilleron Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins
description	Autophagy adaptors and receptors contain LC3-interacting region (LIR) motifs that bind selectively to the LIR docking site of GABARAP and other members of the ATG8 family. Here the authors show that in addition to the LIR motif also the region C-terminal of it is important for the binding specificity of both the centriolar satellite protein PCM1 and the ULK1 complex to GABARAP subfamily proteins.
format	article
author	Martina Wirth Wenxin Zhang Minoo Razi Lynet Nyoni Dhira Joshi Nicola O’Reilly Terje Johansen Sharon A. Tooze Stéphane Mouilleron
author_facet	Martina Wirth Wenxin Zhang Minoo Razi Lynet Nyoni Dhira Joshi Nicola O’Reilly Terje Johansen Sharon A. Tooze Stéphane Mouilleron
author_sort	Martina Wirth
title	Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins
title_short	Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins
title_full	Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins
title_fullStr	Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins
title_full_unstemmed	Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins
title_sort	molecular determinants regulating selective binding of autophagy adapters and receptors to atg8 proteins
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/61625672f9c642f79baf4e0b2c21a97b
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Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins

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