Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins

Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins

Autophagy adaptors and receptors contain LC3-interacting region (LIR) motifs that bind selectively to the LIR docking site of GABARAP and other members of the ATG8 family. Here the authors show that in addition to the LIR motif also the region C-terminal of it is important for the binding specificit...

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Autores principales: Martina Wirth, Wenxin Zhang, Minoo Razi, Lynet Nyoni, Dhira Joshi, Nicola O’Reilly, Terje Johansen, Sharon A. Tooze, Stéphane Mouilleron
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/61625672f9c642f79baf4e0b2c21a97b
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