Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins

Autophagy adaptors and receptors contain LC3-interacting region (LIR) motifs that bind selectively to the LIR docking site of GABARAP and other members of the ATG8 family. Here the authors show that in addition to the LIR motif also the region C-terminal of it is important for the binding specificit...

Full description

Saved in:
Bibliographic Details
Main Authors: Martina Wirth, Wenxin Zhang, Minoo Razi, Lynet Nyoni, Dhira Joshi, Nicola O’Reilly, Terje Johansen, Sharon A. Tooze, Stéphane Mouilleron
Format: article
Language:EN
Published: Nature Portfolio 2019
Subjects:
Q
Online Access:https://doaj.org/article/61625672f9c642f79baf4e0b2c21a97b
Tags: Add Tag
No Tags, Be the first to tag this record!