Low-pathogenic avian influenza viruses in wild house mice.

<h4>Background</h4>Avian influenza viruses are known to productively infect a number of mammal species, several of which are commonly found on or near poultry and gamebird farms. While control of rodent species is often used to limit avian influenza virus transmission within and among ou...

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Autores principales:	Susan A Shriner, Kaci K VanDalen, Nicole L Mooers, Jeremy W Ellis, Heather J Sullivan, J Jeffrey Root, Angela M Pelzel, Alan B Franklin
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6162b479db744a7995926f842958f243
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spelling	oai:doaj.org-article:6162b479db744a7995926f842958f2432021-11-18T07:15:20ZLow-pathogenic avian influenza viruses in wild house mice.1932-620310.1371/journal.pone.0039206https://doaj.org/article/6162b479db744a7995926f842958f2432012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22720076/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Avian influenza viruses are known to productively infect a number of mammal species, several of which are commonly found on or near poultry and gamebird farms. While control of rodent species is often used to limit avian influenza virus transmission within and among outbreak sites, few studies have investigated the potential role of these species in outbreak dynamics.<h4>Methodology/principal findings</h4>We trapped and sampled synanthropic mammals on a gamebird farm in Idaho, USA that had recently experienced a low pathogenic avian influenza outbreak. Six of six house mice (Mus musculus) caught on the outbreak farm were presumptively positive for antibodies to type A influenza. Consequently, we experimentally infected groups of naïve wild-caught house mice with five different low pathogenic avian influenza viruses that included three viruses derived from wild birds and two viruses derived from chickens. Virus replication was efficient in house mice inoculated with viruses derived from wild birds and more moderate for chicken-derived viruses. Mean titers (EID(50) equivalents/mL) across all lung samples from seven days of sampling (three mice/day) ranged from 10(3.89) (H3N6) to 10(5.06) (H4N6) for the wild bird viruses and 10(2.08) (H6N2) to 10(2.85) (H4N8) for the chicken-derived viruses. Interestingly, multiple regression models indicated differential replication between sexes, with significantly (p<0.05) higher concentrations of avian influenza RNA found in females compared with males.<h4>Conclusions/significance</h4>Avian influenza viruses replicated efficiently in wild-caught house mice without adaptation, indicating mice may be a risk pathway for movement of avian influenza viruses on poultry and gamebird farms. Differential virus replication between males and females warrants further investigation to determine the generality of this result in avian influenza disease dynamics.Susan A ShrinerKaci K VanDalenNicole L MooersJeremy W EllisHeather J SullivanJ Jeffrey RootAngela M PelzelAlan B FranklinPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 6, p e39206 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Susan A Shriner Kaci K VanDalen Nicole L Mooers Jeremy W Ellis Heather J Sullivan J Jeffrey Root Angela M Pelzel Alan B Franklin Low-pathogenic avian influenza viruses in wild house mice.
description	<h4>Background</h4>Avian influenza viruses are known to productively infect a number of mammal species, several of which are commonly found on or near poultry and gamebird farms. While control of rodent species is often used to limit avian influenza virus transmission within and among outbreak sites, few studies have investigated the potential role of these species in outbreak dynamics.<h4>Methodology/principal findings</h4>We trapped and sampled synanthropic mammals on a gamebird farm in Idaho, USA that had recently experienced a low pathogenic avian influenza outbreak. Six of six house mice (Mus musculus) caught on the outbreak farm were presumptively positive for antibodies to type A influenza. Consequently, we experimentally infected groups of naïve wild-caught house mice with five different low pathogenic avian influenza viruses that included three viruses derived from wild birds and two viruses derived from chickens. Virus replication was efficient in house mice inoculated with viruses derived from wild birds and more moderate for chicken-derived viruses. Mean titers (EID(50) equivalents/mL) across all lung samples from seven days of sampling (three mice/day) ranged from 10(3.89) (H3N6) to 10(5.06) (H4N6) for the wild bird viruses and 10(2.08) (H6N2) to 10(2.85) (H4N8) for the chicken-derived viruses. Interestingly, multiple regression models indicated differential replication between sexes, with significantly (p<0.05) higher concentrations of avian influenza RNA found in females compared with males.<h4>Conclusions/significance</h4>Avian influenza viruses replicated efficiently in wild-caught house mice without adaptation, indicating mice may be a risk pathway for movement of avian influenza viruses on poultry and gamebird farms. Differential virus replication between males and females warrants further investigation to determine the generality of this result in avian influenza disease dynamics.
format	article
author	Susan A Shriner Kaci K VanDalen Nicole L Mooers Jeremy W Ellis Heather J Sullivan J Jeffrey Root Angela M Pelzel Alan B Franklin
author_facet	Susan A Shriner Kaci K VanDalen Nicole L Mooers Jeremy W Ellis Heather J Sullivan J Jeffrey Root Angela M Pelzel Alan B Franklin
author_sort	Susan A Shriner
title	Low-pathogenic avian influenza viruses in wild house mice.
title_short	Low-pathogenic avian influenza viruses in wild house mice.
title_full	Low-pathogenic avian influenza viruses in wild house mice.
title_fullStr	Low-pathogenic avian influenza viruses in wild house mice.
title_full_unstemmed	Low-pathogenic avian influenza viruses in wild house mice.
title_sort	low-pathogenic avian influenza viruses in wild house mice.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/6162b479db744a7995926f842958f243
work_keys_str_mv	AT susanashriner lowpathogenicavianinfluenzavirusesinwildhousemice AT kacikvandalen lowpathogenicavianinfluenzavirusesinwildhousemice AT nicolelmooers lowpathogenicavianinfluenzavirusesinwildhousemice AT jeremywellis lowpathogenicavianinfluenzavirusesinwildhousemice AT heatherjsullivan lowpathogenicavianinfluenzavirusesinwildhousemice AT jjeffreyroot lowpathogenicavianinfluenzavirusesinwildhousemice AT angelampelzel lowpathogenicavianinfluenzavirusesinwildhousemice AT alanbfranklin lowpathogenicavianinfluenzavirusesinwildhousemice
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Low-pathogenic avian influenza viruses in wild house mice.

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