Graphene oxide-reinforced biodegradable genipin-cross-linked chitosan fluorescent biocomposite film and its cytocompatibility

Jianhua Li,1 Na Ren1, Jichuan Qiu,1 Xiaoning Mou,2 Hong Liu1,21Center of Bio and Micro/Nano Functional Materials, State Key Laboratory of Crystal Materials, Shandong University, Jinan, People's Republic of China; 2Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences,...

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Autores principales:	Li JH, Ren N, Qiu JC, Mou XN, Liu H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/616304e7fc0645428c4997a7bacd8a8b
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spelling	oai:doaj.org-article:616304e7fc0645428c4997a7bacd8a8b2021-12-02T05:39:46ZGraphene oxide-reinforced biodegradable genipin-cross-linked chitosan fluorescent biocomposite film and its cytocompatibility1176-91141178-2013https://doaj.org/article/616304e7fc0645428c4997a7bacd8a8b2013-09-01T00:00:00Zhttp://www.dovepress.com/graphene-oxide-reinforced-biodegradable-genipin-cross-linked-chitosan--a14237https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Jianhua Li,1 Na Ren1, Jichuan Qiu,1 Xiaoning Mou,2 Hong Liu1,21Center of Bio and Micro/Nano Functional Materials, State Key Laboratory of Crystal Materials, Shandong University, Jinan, People's Republic of China; 2Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, People's Republic of ChinaAbstract: A genipin-cross-linked chitosan/graphene oxide (GCS/GO) composite film was prepared using a solution casting method. Fourier transform infrared (FTIR) and ultraviolet-visible (UV-Vis) spectroscopy of the composite films showed that the interactions between the CS and oxygen-containing groups of GO resulted in good dispersion of the GO sheets in the CS network. The addition of GO decreased the expansion ratio of the composite films in physiological conditions and increased the resistance to degradation by lysozymes in vitro. As well, the tensile strength values of the GCS/GO films were significantly increased with the increasing load of GO. Moreover, the GCS/GO composite film also maintained the intrinsic fluorescence of GCS. The in vitro cell study results revealed that the composite films were suitable for the proliferation and adhesion of mouse preosteoblast (MC3T3-E1) cells. The GCS/GO biocomposite films might have a potential use in tissue engineering, bioimaging, and drug delivery.Keywords: chitosan film degradation, fluorescence, cytocompatibilityLi JHRen NQiu JCMou XNLiu HDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss default, Pp 3415-3426 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Li JH Ren N Qiu JC Mou XN Liu H Graphene oxide-reinforced biodegradable genipin-cross-linked chitosan fluorescent biocomposite film and its cytocompatibility
description	Jianhua Li,1 Na Ren1, Jichuan Qiu,1 Xiaoning Mou,2 Hong Liu1,21Center of Bio and Micro/Nano Functional Materials, State Key Laboratory of Crystal Materials, Shandong University, Jinan, People's Republic of China; 2Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, People's Republic of ChinaAbstract: A genipin-cross-linked chitosan/graphene oxide (GCS/GO) composite film was prepared using a solution casting method. Fourier transform infrared (FTIR) and ultraviolet-visible (UV-Vis) spectroscopy of the composite films showed that the interactions between the CS and oxygen-containing groups of GO resulted in good dispersion of the GO sheets in the CS network. The addition of GO decreased the expansion ratio of the composite films in physiological conditions and increased the resistance to degradation by lysozymes in vitro. As well, the tensile strength values of the GCS/GO films were significantly increased with the increasing load of GO. Moreover, the GCS/GO composite film also maintained the intrinsic fluorescence of GCS. The in vitro cell study results revealed that the composite films were suitable for the proliferation and adhesion of mouse preosteoblast (MC3T3-E1) cells. The GCS/GO biocomposite films might have a potential use in tissue engineering, bioimaging, and drug delivery.Keywords: chitosan film degradation, fluorescence, cytocompatibility
format	article
author	Li JH Ren N Qiu JC Mou XN Liu H
author_facet	Li JH Ren N Qiu JC Mou XN Liu H
author_sort	Li JH
title	Graphene oxide-reinforced biodegradable genipin-cross-linked chitosan fluorescent biocomposite film and its cytocompatibility
title_short	Graphene oxide-reinforced biodegradable genipin-cross-linked chitosan fluorescent biocomposite film and its cytocompatibility
title_full	Graphene oxide-reinforced biodegradable genipin-cross-linked chitosan fluorescent biocomposite film and its cytocompatibility
title_fullStr	Graphene oxide-reinforced biodegradable genipin-cross-linked chitosan fluorescent biocomposite film and its cytocompatibility
title_full_unstemmed	Graphene oxide-reinforced biodegradable genipin-cross-linked chitosan fluorescent biocomposite film and its cytocompatibility
title_sort	graphene oxide-reinforced biodegradable genipin-cross-linked chitosan fluorescent biocomposite film and its cytocompatibility
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/616304e7fc0645428c4997a7bacd8a8b
work_keys_str_mv	AT lijh grapheneoxidereinforcedbiodegradablegenipincrosslinkedchitosanfluorescentbiocompositefilmanditscytocompatibility AT renn grapheneoxidereinforcedbiodegradablegenipincrosslinkedchitosanfluorescentbiocompositefilmanditscytocompatibility AT qiujc grapheneoxidereinforcedbiodegradablegenipincrosslinkedchitosanfluorescentbiocompositefilmanditscytocompatibility AT mouxn grapheneoxidereinforcedbiodegradablegenipincrosslinkedchitosanfluorescentbiocompositefilmanditscytocompatibility AT liuh grapheneoxidereinforcedbiodegradablegenipincrosslinkedchitosanfluorescentbiocompositefilmanditscytocompatibility
_version_	1718400299965612032

Graphene oxide-reinforced biodegradable genipin-cross-linked chitosan fluorescent biocomposite film and its cytocompatibility

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