Self-assembled silk fibroin nanoparticles loaded with binary drugs in the treatment of breast carcinoma

Hui Li,1,* Jian Tian,1,2,* Anqing Wu,2 Jiamin Wang,1 Cuicui Ge,2 Ziling Sun1–3 1School of Biological and Basic Medical Science, 2School of Radiological & Interdisciplinary Sciences, Soochow University, 3Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Educat...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Li H, Tian J, Wu A, Wang J, Ge C, Sun Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Silk fibroin nanoparticles 5-fuorouracil;Curcumin Breast Carcinoma Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6163973732534e66aae4980b88c05b7c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6163973732534e66aae4980b88c05b7c
record_format	dspace
spelling	oai:doaj.org-article:6163973732534e66aae4980b88c05b7c2021-12-02T04:33:04ZSelf-assembled silk fibroin nanoparticles loaded with binary drugs in the treatment of breast carcinoma1178-2013https://doaj.org/article/6163973732534e66aae4980b88c05b7c2016-09-01T00:00:00Zhttps://www.dovepress.com/self-assembled-silk-fibroin-nanoparticles-loaded-with-binary-drugs-in--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Hui Li,1,* Jian Tian,1,2,* Anqing Wu,2 Jiamin Wang,1 Cuicui Ge,2 Ziling Sun1–3 1School of Biological and Basic Medical Science, 2School of Radiological & Interdisciplinary Sciences, Soochow University, 3Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Suzhou, Jiangsu, People’s Republic of China *These authors contributed equally to this work Abstract: Self-assembled nanoparticles of the natural polymer, silk fibroin (SF), are a very promising candidate in drug delivery due to their biocompatible and biodegradable properties. In this study, SF nanoparticles loaded with 5-fluorouracil (5-FU) and curcumin with size 217±0.4 nm and with a loading efficacy of 45% and 15% for 5-FU and curcumin, respectively, were prepared. The in vitro release effect of 5-FU and curcumin from nanoparticles was evaluated as ~100% and ~5%, respectively. It has been revealed that the application of such a nanodrug can increase the level of reactive oxygen species, which in turn induces apoptosis of cancer cells in vitro. Animal studies have shown that tumors could be noticeably reduced after being injected with the drug-entrapped nanoparticles. More apoptotic cells were found after 7 days of treatment with SF nanoparticles by a hematoxylin–eosin staining assay. These results demonstrate the future potential of nanoparticle-loaded binary drugs in the treatment of breast cancer. Keywords: silk fibroin nanoparticles, 5-flurouracil, curcumin, reactive oxygen speciesLi HTian JWu AWang JGe CSun ZDove Medical PressarticleSilk fibroin nanoparticles5-fuorouracil;CurcuminBreast CarcinomaMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 11, Pp 4373-4380 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Silk fibroin nanoparticles 5-fuorouracil;Curcumin Breast Carcinoma Medicine (General) R5-920
spellingShingle	Silk fibroin nanoparticles 5-fuorouracil;Curcumin Breast Carcinoma Medicine (General) R5-920 Li H Tian J Wu A Wang J Ge C Sun Z Self-assembled silk fibroin nanoparticles loaded with binary drugs in the treatment of breast carcinoma
description	Hui Li,1,* Jian Tian,1,2,* Anqing Wu,2 Jiamin Wang,1 Cuicui Ge,2 Ziling Sun1–3 1School of Biological and Basic Medical Science, 2School of Radiological & Interdisciplinary Sciences, Soochow University, 3Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Suzhou, Jiangsu, People’s Republic of China *These authors contributed equally to this work Abstract: Self-assembled nanoparticles of the natural polymer, silk fibroin (SF), are a very promising candidate in drug delivery due to their biocompatible and biodegradable properties. In this study, SF nanoparticles loaded with 5-fluorouracil (5-FU) and curcumin with size 217±0.4 nm and with a loading efficacy of 45% and 15% for 5-FU and curcumin, respectively, were prepared. The in vitro release effect of 5-FU and curcumin from nanoparticles was evaluated as ~100% and ~5%, respectively. It has been revealed that the application of such a nanodrug can increase the level of reactive oxygen species, which in turn induces apoptosis of cancer cells in vitro. Animal studies have shown that tumors could be noticeably reduced after being injected with the drug-entrapped nanoparticles. More apoptotic cells were found after 7 days of treatment with SF nanoparticles by a hematoxylin–eosin staining assay. These results demonstrate the future potential of nanoparticle-loaded binary drugs in the treatment of breast cancer. Keywords: silk fibroin nanoparticles, 5-flurouracil, curcumin, reactive oxygen species
format	article
author	Li H Tian J Wu A Wang J Ge C Sun Z
author_facet	Li H Tian J Wu A Wang J Ge C Sun Z
author_sort	Li H
title	Self-assembled silk fibroin nanoparticles loaded with binary drugs in the treatment of breast carcinoma
title_short	Self-assembled silk fibroin nanoparticles loaded with binary drugs in the treatment of breast carcinoma
title_full	Self-assembled silk fibroin nanoparticles loaded with binary drugs in the treatment of breast carcinoma
title_fullStr	Self-assembled silk fibroin nanoparticles loaded with binary drugs in the treatment of breast carcinoma
title_full_unstemmed	Self-assembled silk fibroin nanoparticles loaded with binary drugs in the treatment of breast carcinoma
title_sort	self-assembled silk fibroin nanoparticles loaded with binary drugs in the treatment of breast carcinoma
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/6163973732534e66aae4980b88c05b7c
work_keys_str_mv	AT lih selfassembledsilkfibroinnanoparticlesloadedwithbinarydrugsinthetreatmentofbreastcarcinoma AT tianj selfassembledsilkfibroinnanoparticlesloadedwithbinarydrugsinthetreatmentofbreastcarcinoma AT wua selfassembledsilkfibroinnanoparticlesloadedwithbinarydrugsinthetreatmentofbreastcarcinoma AT wangj selfassembledsilkfibroinnanoparticlesloadedwithbinarydrugsinthetreatmentofbreastcarcinoma AT gec selfassembledsilkfibroinnanoparticlesloadedwithbinarydrugsinthetreatmentofbreastcarcinoma AT sunz selfassembledsilkfibroinnanoparticlesloadedwithbinarydrugsinthetreatmentofbreastcarcinoma
_version_	1718401187100753920

Self-assembled silk fibroin nanoparticles loaded with binary drugs in the treatment of breast carcinoma

Ejemplares similares