Establishment of the relationship between tumor size and range of histological involvement to evaluate the rationality of current retinoblastoma management.

<h4>Purpose</h4>To determine whether tumor size correlates with histopathological involvement and hence evaluate the rationality of conservative treatment for retinoblastoma.<h4>Methods</h4>We retrospectively studied 221 patients (221 eyes) treated for retinoblastoma with enu...

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Autores principales:	Jianhua Yan, Hao Zhang, Yongping Li
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/616830ccf8be49e88aa9443ba0ae787c
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spelling	oai:doaj.org-article:616830ccf8be49e88aa9443ba0ae787c2021-11-18T08:44:18ZEstablishment of the relationship between tumor size and range of histological involvement to evaluate the rationality of current retinoblastoma management.1932-620310.1371/journal.pone.0080484https://doaj.org/article/616830ccf8be49e88aa9443ba0ae787c2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24312226/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Purpose</h4>To determine whether tumor size correlates with histopathological involvement and hence evaluate the rationality of conservative treatment for retinoblastoma.<h4>Methods</h4>We retrospectively studied 221 patients (221 eyes) treated for retinoblastoma with enucleation in the Zhongshan Ophthalmic Center of Sun Yat-sen University, China, from October 1995 to December 2004. Histopathological data included involvement of the anterior chamber, sclera, choroids, and optic nerve. Tumor size was measured by B-ultrasound examination.<h4>Results</h4>Tumor invasion of the optic nerve correlated with the Reese-Ellsworth (R-E) staging system and the International Classification for Retinoblastoma (ICRB): optic nerve involvement was significantly more frequent in R-E stage V (P = 0.009) and ICRB Group E (P = 0.002) cases. However, 19.1% of patients with R-E stage I, II and III, and 16.7% of patients with ICRB Group B and C disease showed histopathological involvement of the postlaminar optic nerve. Extraocular involvement was observed in 17.7% of tumors ≤ 15 mm in diameter. Tumors >15 mm in diameter showed greater extraocular involvement, including the optic nerve (P = 0.000) and sclera (P = 0.032), than tumors ≤ 15 mm in diameter. Postlaminar optic nerve invasion was observed in 19.6% of tumors ≤ 10 mm in thickness. Tumors >10 mm in thickness had sclera involvement more frequently than tumors ≤ 10 mm in thickness (P = 0.029). Postlaminar optic nerve invasion was noted in 17.1% of patients with tumors ≤ 15 mm in diameter and ≤ 10 mm in thickness.<h4>Conclusions</h4>Medium-sized retinoblastomas frequently invade outside the globe. Thus, indications for conservative treatment need improvement.Jianhua YanHao ZhangYongping LiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e80484 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jianhua Yan Hao Zhang Yongping Li Establishment of the relationship between tumor size and range of histological involvement to evaluate the rationality of current retinoblastoma management.
description	<h4>Purpose</h4>To determine whether tumor size correlates with histopathological involvement and hence evaluate the rationality of conservative treatment for retinoblastoma.<h4>Methods</h4>We retrospectively studied 221 patients (221 eyes) treated for retinoblastoma with enucleation in the Zhongshan Ophthalmic Center of Sun Yat-sen University, China, from October 1995 to December 2004. Histopathological data included involvement of the anterior chamber, sclera, choroids, and optic nerve. Tumor size was measured by B-ultrasound examination.<h4>Results</h4>Tumor invasion of the optic nerve correlated with the Reese-Ellsworth (R-E) staging system and the International Classification for Retinoblastoma (ICRB): optic nerve involvement was significantly more frequent in R-E stage V (P = 0.009) and ICRB Group E (P = 0.002) cases. However, 19.1% of patients with R-E stage I, II and III, and 16.7% of patients with ICRB Group B and C disease showed histopathological involvement of the postlaminar optic nerve. Extraocular involvement was observed in 17.7% of tumors ≤ 15 mm in diameter. Tumors >15 mm in diameter showed greater extraocular involvement, including the optic nerve (P = 0.000) and sclera (P = 0.032), than tumors ≤ 15 mm in diameter. Postlaminar optic nerve invasion was observed in 19.6% of tumors ≤ 10 mm in thickness. Tumors >10 mm in thickness had sclera involvement more frequently than tumors ≤ 10 mm in thickness (P = 0.029). Postlaminar optic nerve invasion was noted in 17.1% of patients with tumors ≤ 15 mm in diameter and ≤ 10 mm in thickness.<h4>Conclusions</h4>Medium-sized retinoblastomas frequently invade outside the globe. Thus, indications for conservative treatment need improvement.
format	article
author	Jianhua Yan Hao Zhang Yongping Li
author_facet	Jianhua Yan Hao Zhang Yongping Li
author_sort	Jianhua Yan
title	Establishment of the relationship between tumor size and range of histological involvement to evaluate the rationality of current retinoblastoma management.
title_short	Establishment of the relationship between tumor size and range of histological involvement to evaluate the rationality of current retinoblastoma management.
title_full	Establishment of the relationship between tumor size and range of histological involvement to evaluate the rationality of current retinoblastoma management.
title_fullStr	Establishment of the relationship between tumor size and range of histological involvement to evaluate the rationality of current retinoblastoma management.
title_full_unstemmed	Establishment of the relationship between tumor size and range of histological involvement to evaluate the rationality of current retinoblastoma management.
title_sort	establishment of the relationship between tumor size and range of histological involvement to evaluate the rationality of current retinoblastoma management.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/616830ccf8be49e88aa9443ba0ae787c
work_keys_str_mv	AT jianhuayan establishmentoftherelationshipbetweentumorsizeandrangeofhistologicalinvolvementtoevaluatetherationalityofcurrentretinoblastomamanagement AT haozhang establishmentoftherelationshipbetweentumorsizeandrangeofhistologicalinvolvementtoevaluatetherationalityofcurrentretinoblastomamanagement AT yongpingli establishmentoftherelationshipbetweentumorsizeandrangeofhistologicalinvolvementtoevaluatetherationalityofcurrentretinoblastomamanagement
_version_	1718421386048831488

Establishment of the relationship between tumor size and range of histological involvement to evaluate the rationality of current retinoblastoma management.

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