KRAS-related noncoding RNAs in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with a poor overall prognosis. However, curative resection during the early stages of the disease can greatly improve survival rates, highlighting the importance of early screening and detection. Studies of noncoding RNAs, primarily microRN...

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Autores principales:	Shuang-Ni Yu, Yi-Hui Ma, Wu-Gan Zhao, Xiang-Lan Jin, Hai-Yan Yang, Ping-Ping Liu, Jie Chen
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2016
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/616dfffbe4b94d05bbfda3011c760d44
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spelling	oai:doaj.org-article:616dfffbe4b94d05bbfda3011c760d442021-12-02T13:42:26ZKRAS-related noncoding RNAs in pancreatic ductal adenocarcinoma2095-882X10.1016/j.cdtm.2016.11.012https://doaj.org/article/616dfffbe4b94d05bbfda3011c760d442016-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X16300767https://doaj.org/toc/2095-882XPancreatic ductal adenocarcinoma (PDAC) is a lethal disease with a poor overall prognosis. However, curative resection during the early stages of the disease can greatly improve survival rates, highlighting the importance of early screening and detection. Studies of noncoding RNAs, primarily microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), provide important insights into strategies for the early detection of KRAS-driven PDAC. Here, we summarize our studies and review current reports on research investigating KRAS-related miRNAs and lncRNAs, emphasizing their aberrant expression, mechanisms, carcinogenic effects, and prognostic and predictive capacities in PDAC. Keywords: Pancreatic ductal adenocarcinoma, KRAS, Noncoding RNAs, microRNAs, Long noncoding RNAsShuang-Ni YuYi-Hui MaWu-Gan ZhaoXiang-Lan JinHai-Yan YangPing-Ping LiuJie ChenKeAi Communications Co., Ltd.articleMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 2, Iss 4, Pp 215-222 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Shuang-Ni Yu Yi-Hui Ma Wu-Gan Zhao Xiang-Lan Jin Hai-Yan Yang Ping-Ping Liu Jie Chen KRAS-related noncoding RNAs in pancreatic ductal adenocarcinoma
description	Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with a poor overall prognosis. However, curative resection during the early stages of the disease can greatly improve survival rates, highlighting the importance of early screening and detection. Studies of noncoding RNAs, primarily microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), provide important insights into strategies for the early detection of KRAS-driven PDAC. Here, we summarize our studies and review current reports on research investigating KRAS-related miRNAs and lncRNAs, emphasizing their aberrant expression, mechanisms, carcinogenic effects, and prognostic and predictive capacities in PDAC. Keywords: Pancreatic ductal adenocarcinoma, KRAS, Noncoding RNAs, microRNAs, Long noncoding RNAs
format	article
author	Shuang-Ni Yu Yi-Hui Ma Wu-Gan Zhao Xiang-Lan Jin Hai-Yan Yang Ping-Ping Liu Jie Chen
author_facet	Shuang-Ni Yu Yi-Hui Ma Wu-Gan Zhao Xiang-Lan Jin Hai-Yan Yang Ping-Ping Liu Jie Chen
author_sort	Shuang-Ni Yu
title	KRAS-related noncoding RNAs in pancreatic ductal adenocarcinoma
title_short	KRAS-related noncoding RNAs in pancreatic ductal adenocarcinoma
title_full	KRAS-related noncoding RNAs in pancreatic ductal adenocarcinoma
title_fullStr	KRAS-related noncoding RNAs in pancreatic ductal adenocarcinoma
title_full_unstemmed	KRAS-related noncoding RNAs in pancreatic ductal adenocarcinoma
title_sort	kras-related noncoding rnas in pancreatic ductal adenocarcinoma
publisher	KeAi Communications Co., Ltd.
publishDate	2016
url	https://doaj.org/article/616dfffbe4b94d05bbfda3011c760d44
work_keys_str_mv	AT shuangniyu krasrelatednoncodingrnasinpancreaticductaladenocarcinoma AT yihuima krasrelatednoncodingrnasinpancreaticductaladenocarcinoma AT wuganzhao krasrelatednoncodingrnasinpancreaticductaladenocarcinoma AT xianglanjin krasrelatednoncodingrnasinpancreaticductaladenocarcinoma AT haiyanyang krasrelatednoncodingrnasinpancreaticductaladenocarcinoma AT pingpingliu krasrelatednoncodingrnasinpancreaticductaladenocarcinoma AT jiechen krasrelatednoncodingrnasinpancreaticductaladenocarcinoma
_version_	1718392555916230656

KRAS-related noncoding RNAs in pancreatic ductal adenocarcinoma

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