High Fat Diet Triggers a Reduction in Body Fat Mass in Female Mice Deficient for Utx demethylase

Abstract Obesity increases the risk of metabolic disorders like diabetes mellitus and dyslipidemia. However, how metabolic status is sensed and regulates cellular behavior is unclear. Utx is an H3K27 demethylase that influences adipocyte function in vitro. To examine its role in vivo, we generated m...

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Autores principales:	Kazushige Ota, Akiyoshi Komuro, Hisayuki Amano, Akinori Kanai, Kai Ge, Takeshi Ueda, Hitoshi Okada
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/61739a8843d14250a281079be978bd08
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spelling	oai:doaj.org-article:61739a8843d14250a281079be978bd082021-12-02T15:09:12ZHigh Fat Diet Triggers a Reduction in Body Fat Mass in Female Mice Deficient for Utx demethylase10.1038/s41598-019-46445-92045-2322https://doaj.org/article/61739a8843d14250a281079be978bd082019-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-46445-9https://doaj.org/toc/2045-2322Abstract Obesity increases the risk of metabolic disorders like diabetes mellitus and dyslipidemia. However, how metabolic status is sensed and regulates cellular behavior is unclear. Utx is an H3K27 demethylase that influences adipocyte function in vitro. To examine its role in vivo, we generated mice lacking Utx in adipocytes (UtxAKO). Although all UtxAKO mice grew normally on a normal chow diet (NCD), female UtxAKO mice on a high fat diet (HFD) showed striking reductions in body fat compared to control mice (Ctrl). Gene expression profiling of adipose tissues of HFD-fed UtxAKO female mice revealed decreased expression of rate-limiting enzymes of triacylglycerol synthesis but increased expression of those of cholesterol/steroid hormone synthesis. Moreover, these animals resisted adiposity induced by ovariectomy and exhibited increased estrogen in visceral adipose tissues. Thus, upon HFD feeding, Utx regulates lipid metabolism in adipose tissues by influencing the local hormonal microenvironment. Conversely, Utx deficiency skews lipid catabolism to enhance cholesterol/steroid hormone production and repress obesity.Kazushige OtaAkiyoshi KomuroHisayuki AmanoAkinori KanaiKai GeTakeshi UedaHitoshi OkadaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kazushige Ota Akiyoshi Komuro Hisayuki Amano Akinori Kanai Kai Ge Takeshi Ueda Hitoshi Okada High Fat Diet Triggers a Reduction in Body Fat Mass in Female Mice Deficient for Utx demethylase
description	Abstract Obesity increases the risk of metabolic disorders like diabetes mellitus and dyslipidemia. However, how metabolic status is sensed and regulates cellular behavior is unclear. Utx is an H3K27 demethylase that influences adipocyte function in vitro. To examine its role in vivo, we generated mice lacking Utx in adipocytes (UtxAKO). Although all UtxAKO mice grew normally on a normal chow diet (NCD), female UtxAKO mice on a high fat diet (HFD) showed striking reductions in body fat compared to control mice (Ctrl). Gene expression profiling of adipose tissues of HFD-fed UtxAKO female mice revealed decreased expression of rate-limiting enzymes of triacylglycerol synthesis but increased expression of those of cholesterol/steroid hormone synthesis. Moreover, these animals resisted adiposity induced by ovariectomy and exhibited increased estrogen in visceral adipose tissues. Thus, upon HFD feeding, Utx regulates lipid metabolism in adipose tissues by influencing the local hormonal microenvironment. Conversely, Utx deficiency skews lipid catabolism to enhance cholesterol/steroid hormone production and repress obesity.
format	article
author	Kazushige Ota Akiyoshi Komuro Hisayuki Amano Akinori Kanai Kai Ge Takeshi Ueda Hitoshi Okada
author_facet	Kazushige Ota Akiyoshi Komuro Hisayuki Amano Akinori Kanai Kai Ge Takeshi Ueda Hitoshi Okada
author_sort	Kazushige Ota
title	High Fat Diet Triggers a Reduction in Body Fat Mass in Female Mice Deficient for Utx demethylase
title_short	High Fat Diet Triggers a Reduction in Body Fat Mass in Female Mice Deficient for Utx demethylase
title_full	High Fat Diet Triggers a Reduction in Body Fat Mass in Female Mice Deficient for Utx demethylase
title_fullStr	High Fat Diet Triggers a Reduction in Body Fat Mass in Female Mice Deficient for Utx demethylase
title_full_unstemmed	High Fat Diet Triggers a Reduction in Body Fat Mass in Female Mice Deficient for Utx demethylase
title_sort	high fat diet triggers a reduction in body fat mass in female mice deficient for utx demethylase
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/61739a8843d14250a281079be978bd08
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High Fat Diet Triggers a Reduction in Body Fat Mass in Female Mice Deficient for Utx demethylase

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