A biomaterial with a channel-like pore architecture induces endochondral healing of bone defects

A bioengineering approach to enhance the regeneration of large bone defects is lacking. Here, the authors show that a biomaterial scaffold with a channel-like pore architecture enables organized endochondral ossification through directional cell recruitment and extracellular matrix alignment.

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Autores principales:	A. Petersen, A. Princ, G. Korus, A. Ellinghaus, H. Leemhuis, A. Herrera, A. Klaumünzer, S. Schreivogel, A. Woloszyk, K. Schmidt-Bleek, S. Geissler, I. Heschel, G. N. Duda
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6173f1f6a0e44b58b39f4c51d976aca8
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spelling	oai:doaj.org-article:6173f1f6a0e44b58b39f4c51d976aca82021-12-02T14:41:28ZA biomaterial with a channel-like pore architecture induces endochondral healing of bone defects10.1038/s41467-018-06504-72041-1723https://doaj.org/article/6173f1f6a0e44b58b39f4c51d976aca82018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06504-7https://doaj.org/toc/2041-1723A bioengineering approach to enhance the regeneration of large bone defects is lacking. Here, the authors show that a biomaterial scaffold with a channel-like pore architecture enables organized endochondral ossification through directional cell recruitment and extracellular matrix alignment.A. PetersenA. PrincG. KorusA. EllinghausH. LeemhuisA. HerreraA. KlaumünzerS. SchreivogelA. WoloszykK. Schmidt-BleekS. GeisslerI. HeschelG. N. DudaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q A. Petersen A. Princ G. Korus A. Ellinghaus H. Leemhuis A. Herrera A. Klaumünzer S. Schreivogel A. Woloszyk K. Schmidt-Bleek S. Geissler I. Heschel G. N. Duda A biomaterial with a channel-like pore architecture induces endochondral healing of bone defects
description	A bioengineering approach to enhance the regeneration of large bone defects is lacking. Here, the authors show that a biomaterial scaffold with a channel-like pore architecture enables organized endochondral ossification through directional cell recruitment and extracellular matrix alignment.
format	article
author	A. Petersen A. Princ G. Korus A. Ellinghaus H. Leemhuis A. Herrera A. Klaumünzer S. Schreivogel A. Woloszyk K. Schmidt-Bleek S. Geissler I. Heschel G. N. Duda
author_facet	A. Petersen A. Princ G. Korus A. Ellinghaus H. Leemhuis A. Herrera A. Klaumünzer S. Schreivogel A. Woloszyk K. Schmidt-Bleek S. Geissler I. Heschel G. N. Duda
author_sort	A. Petersen
title	A biomaterial with a channel-like pore architecture induces endochondral healing of bone defects
title_short	A biomaterial with a channel-like pore architecture induces endochondral healing of bone defects
title_full	A biomaterial with a channel-like pore architecture induces endochondral healing of bone defects
title_fullStr	A biomaterial with a channel-like pore architecture induces endochondral healing of bone defects
title_full_unstemmed	A biomaterial with a channel-like pore architecture induces endochondral healing of bone defects
title_sort	biomaterial with a channel-like pore architecture induces endochondral healing of bone defects
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/6173f1f6a0e44b58b39f4c51d976aca8
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A biomaterial with a channel-like pore architecture induces endochondral healing of bone defects

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