Age-related differences in plasma proteins: how plasma proteins change from neonates to adults.

The incidence of major diseases such as cardiovascular disease, thrombosis and cancer increases with age and is the major cause of mortality world-wide, with neonates and children somehow protected from such diseases of ageing. We hypothesized that there are major developmental differences in plasma...

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Autores principales:	Vera Ignjatovic, Cera Lai, Robyn Summerhayes, Ulrike Mathesius, Sherif Tawfilis, Matthew A Perugini, Paul Monagle
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/61749598f18e417db9cf0880511addfb
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spelling	oai:doaj.org-article:61749598f18e417db9cf0880511addfb2021-11-18T06:58:32ZAge-related differences in plasma proteins: how plasma proteins change from neonates to adults.1932-620310.1371/journal.pone.0017213https://doaj.org/article/61749598f18e417db9cf0880511addfb2011-02-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21365000/?tool=EBIhttps://doaj.org/toc/1932-6203The incidence of major diseases such as cardiovascular disease, thrombosis and cancer increases with age and is the major cause of mortality world-wide, with neonates and children somehow protected from such diseases of ageing. We hypothesized that there are major developmental differences in plasma proteins and that these contribute to age-related changes in the incidence of major diseases. We evaluated the human plasma proteome in healthy neonates, children and adults using the 2D-DIGE approach. We demonstrate significant changes in number and abundance of up to 100 protein spots that have marked differences in during the transition of the plasma proteome from neonate and child through to adult. These proteins are known to be involved in numerous physiological processes such as iron transport and homeostasis, immune response, haemostasis and apoptosis, amongst others. Importantly, we determined that the proteins that are differentially expressed with age are not the same proteins that are differentially expressed with gender and that the degree of phosphorylation of plasma proteins also changes with age. Given the multi-functionality of these proteins in human physiology, understanding the differences in the plasma proteome in neonates and children compared to adults will make a major contribution to our understanding of developmental biology in humans.Vera IgnjatovicCera LaiRobyn SummerhayesUlrike MathesiusSherif TawfilisMatthew A PeruginiPaul MonaglePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 2, p e17213 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Vera Ignjatovic Cera Lai Robyn Summerhayes Ulrike Mathesius Sherif Tawfilis Matthew A Perugini Paul Monagle Age-related differences in plasma proteins: how plasma proteins change from neonates to adults.
description	The incidence of major diseases such as cardiovascular disease, thrombosis and cancer increases with age and is the major cause of mortality world-wide, with neonates and children somehow protected from such diseases of ageing. We hypothesized that there are major developmental differences in plasma proteins and that these contribute to age-related changes in the incidence of major diseases. We evaluated the human plasma proteome in healthy neonates, children and adults using the 2D-DIGE approach. We demonstrate significant changes in number and abundance of up to 100 protein spots that have marked differences in during the transition of the plasma proteome from neonate and child through to adult. These proteins are known to be involved in numerous physiological processes such as iron transport and homeostasis, immune response, haemostasis and apoptosis, amongst others. Importantly, we determined that the proteins that are differentially expressed with age are not the same proteins that are differentially expressed with gender and that the degree of phosphorylation of plasma proteins also changes with age. Given the multi-functionality of these proteins in human physiology, understanding the differences in the plasma proteome in neonates and children compared to adults will make a major contribution to our understanding of developmental biology in humans.
format	article
author	Vera Ignjatovic Cera Lai Robyn Summerhayes Ulrike Mathesius Sherif Tawfilis Matthew A Perugini Paul Monagle
author_facet	Vera Ignjatovic Cera Lai Robyn Summerhayes Ulrike Mathesius Sherif Tawfilis Matthew A Perugini Paul Monagle
author_sort	Vera Ignjatovic
title	Age-related differences in plasma proteins: how plasma proteins change from neonates to adults.
title_short	Age-related differences in plasma proteins: how plasma proteins change from neonates to adults.
title_full	Age-related differences in plasma proteins: how plasma proteins change from neonates to adults.
title_fullStr	Age-related differences in plasma proteins: how plasma proteins change from neonates to adults.
title_full_unstemmed	Age-related differences in plasma proteins: how plasma proteins change from neonates to adults.
title_sort	age-related differences in plasma proteins: how plasma proteins change from neonates to adults.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/61749598f18e417db9cf0880511addfb
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Age-related differences in plasma proteins: how plasma proteins change from neonates to adults.

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