Early life stress interacts with the diet deficiency of omega-3 fatty acids during the life course increasing the metabolic vulnerability in adult rats.

Early stress can cause metabolic disorders in adulthood. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) deficiency has also been linked to the development of metabolic disorders. The aim of this study was to assess whether an early stressful event such as maternal separation interacts with the nutr...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Juliana R Bernardi, Charles F Ferreira, Gabrielle Senter, Rachel Krolow, Bianca W de Aguiar, André K Portella, Márcia Kauer-Sant'anna, Flávio Kapczinski, Carla Dalmaz, Marcelo Z Goldani, Patrícia P Silveira
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/617b00850ae44d71a501ce7019a0be3f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:617b00850ae44d71a501ce7019a0be3f
record_format	dspace
spelling	oai:doaj.org-article:617b00850ae44d71a501ce7019a0be3f2021-11-18T07:48:58ZEarly life stress interacts with the diet deficiency of omega-3 fatty acids during the life course increasing the metabolic vulnerability in adult rats.1932-620310.1371/journal.pone.0062031https://doaj.org/article/617b00850ae44d71a501ce7019a0be3f2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23614006/?tool=EBIhttps://doaj.org/toc/1932-6203Early stress can cause metabolic disorders in adulthood. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) deficiency has also been linked to the development of metabolic disorders. The aim of this study was to assess whether an early stressful event such as maternal separation interacts with the nutritional availability of n-3 PUFAs during the life course on metabolic aspects. Litters were randomized into: maternal separated (MS) and non-handled (NH). The MS group was removed from their dam for 3 hours per day and put in an incubator at 32 °C on days 1° to 10° postnatal (PND). On PND 35, males were subdivided into diets that were adequate or deficient in n-3 PUFAs, and this intervention was applied during the subsequent 15 weeks. Animal's body weight and food consumption were measured weekly, and at the end of the treatment tissues were collected. MS was associated with increased food intake (p = 0.047) and weight gain (p = 0.012), but no differences were found in the NPY hypothalamic content between the groups. MS rats had also increased deposition of abdominal fat (p<0.001) and plasma triglycerides (p = 0.018) when compared to the NH group. Interactions between early life stress and n-3 PUFAs deficiency were found in plasma insulin (p = 0.033), HOMA index (p = 0.049), leptin (p = 0.010) and liver PEPCK expression (p = 0.050), in which the metabolic vulnerability in the MS group was aggravated by the n-3 PUFAs deficient diet exposure. This was associated with specific alterations in the peripheral fatty acid profile. Variations in the neonatal environment interact with nutritional aspects during the life course, such as n-3 PUFAs diet content, and persistently alter the metabolic vulnerability in adulthood.Juliana R BernardiCharles F FerreiraGabrielle SenterRachel KrolowBianca W de AguiarAndré K PortellaMárcia Kauer-Sant'annaFlávio KapczinskiCarla DalmazMarcelo Z GoldaniPatrícia P SilveiraPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 4, p e62031 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Juliana R Bernardi Charles F Ferreira Gabrielle Senter Rachel Krolow Bianca W de Aguiar André K Portella Márcia Kauer-Sant'anna Flávio Kapczinski Carla Dalmaz Marcelo Z Goldani Patrícia P Silveira Early life stress interacts with the diet deficiency of omega-3 fatty acids during the life course increasing the metabolic vulnerability in adult rats.
description	Early stress can cause metabolic disorders in adulthood. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) deficiency has also been linked to the development of metabolic disorders. The aim of this study was to assess whether an early stressful event such as maternal separation interacts with the nutritional availability of n-3 PUFAs during the life course on metabolic aspects. Litters were randomized into: maternal separated (MS) and non-handled (NH). The MS group was removed from their dam for 3 hours per day and put in an incubator at 32 °C on days 1° to 10° postnatal (PND). On PND 35, males were subdivided into diets that were adequate or deficient in n-3 PUFAs, and this intervention was applied during the subsequent 15 weeks. Animal's body weight and food consumption were measured weekly, and at the end of the treatment tissues were collected. MS was associated with increased food intake (p = 0.047) and weight gain (p = 0.012), but no differences were found in the NPY hypothalamic content between the groups. MS rats had also increased deposition of abdominal fat (p<0.001) and plasma triglycerides (p = 0.018) when compared to the NH group. Interactions between early life stress and n-3 PUFAs deficiency were found in plasma insulin (p = 0.033), HOMA index (p = 0.049), leptin (p = 0.010) and liver PEPCK expression (p = 0.050), in which the metabolic vulnerability in the MS group was aggravated by the n-3 PUFAs deficient diet exposure. This was associated with specific alterations in the peripheral fatty acid profile. Variations in the neonatal environment interact with nutritional aspects during the life course, such as n-3 PUFAs diet content, and persistently alter the metabolic vulnerability in adulthood.
format	article
author	Juliana R Bernardi Charles F Ferreira Gabrielle Senter Rachel Krolow Bianca W de Aguiar André K Portella Márcia Kauer-Sant'anna Flávio Kapczinski Carla Dalmaz Marcelo Z Goldani Patrícia P Silveira
author_facet	Juliana R Bernardi Charles F Ferreira Gabrielle Senter Rachel Krolow Bianca W de Aguiar André K Portella Márcia Kauer-Sant'anna Flávio Kapczinski Carla Dalmaz Marcelo Z Goldani Patrícia P Silveira
author_sort	Juliana R Bernardi
title	Early life stress interacts with the diet deficiency of omega-3 fatty acids during the life course increasing the metabolic vulnerability in adult rats.
title_short	Early life stress interacts with the diet deficiency of omega-3 fatty acids during the life course increasing the metabolic vulnerability in adult rats.
title_full	Early life stress interacts with the diet deficiency of omega-3 fatty acids during the life course increasing the metabolic vulnerability in adult rats.
title_fullStr	Early life stress interacts with the diet deficiency of omega-3 fatty acids during the life course increasing the metabolic vulnerability in adult rats.
title_full_unstemmed	Early life stress interacts with the diet deficiency of omega-3 fatty acids during the life course increasing the metabolic vulnerability in adult rats.
title_sort	early life stress interacts with the diet deficiency of omega-3 fatty acids during the life course increasing the metabolic vulnerability in adult rats.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/617b00850ae44d71a501ce7019a0be3f
work_keys_str_mv	AT julianarbernardi earlylifestressinteractswiththedietdeficiencyofomega3fattyacidsduringthelifecourseincreasingthemetabolicvulnerabilityinadultrats AT charlesfferreira earlylifestressinteractswiththedietdeficiencyofomega3fattyacidsduringthelifecourseincreasingthemetabolicvulnerabilityinadultrats AT gabriellesenter earlylifestressinteractswiththedietdeficiencyofomega3fattyacidsduringthelifecourseincreasingthemetabolicvulnerabilityinadultrats AT rachelkrolow earlylifestressinteractswiththedietdeficiencyofomega3fattyacidsduringthelifecourseincreasingthemetabolicvulnerabilityinadultrats AT biancawdeaguiar earlylifestressinteractswiththedietdeficiencyofomega3fattyacidsduringthelifecourseincreasingthemetabolicvulnerabilityinadultrats AT andrekportella earlylifestressinteractswiththedietdeficiencyofomega3fattyacidsduringthelifecourseincreasingthemetabolicvulnerabilityinadultrats AT marciakauersantanna earlylifestressinteractswiththedietdeficiencyofomega3fattyacidsduringthelifecourseincreasingthemetabolicvulnerabilityinadultrats AT flaviokapczinski earlylifestressinteractswiththedietdeficiencyofomega3fattyacidsduringthelifecourseincreasingthemetabolicvulnerabilityinadultrats AT carladalmaz earlylifestressinteractswiththedietdeficiencyofomega3fattyacidsduringthelifecourseincreasingthemetabolicvulnerabilityinadultrats AT marcelozgoldani earlylifestressinteractswiththedietdeficiencyofomega3fattyacidsduringthelifecourseincreasingthemetabolicvulnerabilityinadultrats AT patriciapsilveira earlylifestressinteractswiththedietdeficiencyofomega3fattyacidsduringthelifecourseincreasingthemetabolicvulnerabilityinadultrats
_version_	1718422914209939456

Early life stress interacts with the diet deficiency of omega-3 fatty acids during the life course increasing the metabolic vulnerability in adult rats.

Ejemplares similares