Two-dimensional system based on organic and functional impairment with aging for precisely assessing risk factors in chronic disease

Introduction The aim of the study was to establish a two-dimensional system based on organic and functional biological age (BA) using a biomarker of organic and functional impairment with aging for precisely assessing roles of natural aging and other risk factors in chronic disease. Material and me...

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Autores principales:	Wang Cengfang, Gao Hanboya, Liu Hui
Formato:	article
Lenguaje:	EN
Publicado:	Termedia Publishing House 2019
Materias:	obesity blood pressure aged biomarker aging biological age Medicine R
Acceso en línea:	https://doaj.org/article/617f5cf305354c478e381d3afbd416f1
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spelling	oai:doaj.org-article:617f5cf305354c478e381d3afbd416f12021-12-02T18:39:22ZTwo-dimensional system based on organic and functional impairment with aging for precisely assessing risk factors in chronic disease1734-19221896-915110.5114/aoms.2020.91289https://doaj.org/article/617f5cf305354c478e381d3afbd416f12019-12-01T00:00:00Zhttps://www.archivesofmedicalscience.com/Two-dimensional-system-based-on-organic-and-functional-impairment-with-aging-for,75797,0,2.htmlhttps://doaj.org/toc/1734-1922https://doaj.org/toc/1896-9151Introduction The aim of the study was to establish a two-dimensional system based on organic and functional biological age (BA) using a biomarker of organic and functional impairment with aging for precisely assessing roles of natural aging and other risk factors in chronic disease. Material and methods The index of organic mild impairment, which is similar to the frailty index, was determined with imaging parameters as organic BA. The functional BA was calculated with the following formula: Functional BA = [systolic – diastolic BP (mm Hg)] × waist circumference2 (m) × height0.5 (m)/weight (kg). A total of 1047 subjects undergoing routine health examination were randomly selected to establish a system with organic BA on the X-axis, functional BA on the Y-axis; organic and functional BAs from chronological age with 60 years as a center point of the coordinate system. A total of 85 patients with type 2 diabetes controls were recruited to verify the system. Results Organic and functional BA contributed to chronological age almost equally. Both organic and functional BA increased with chronological age in the two-dimensional system for a random population. There were significant difference for distribution between diabetes and control groups in two-dimensional system (p < 0.05). That both more in quadrant II and lesser in quadrant IV for diabetes were suggested that diabetes was more sensitive to other risk factors than aging. Conclusions Combination of the two BAs could precisely recognized aging and other risk factors according to locations of the disease in each quadrant and quantitatively assessed status of nature aging and disease-related aging in a individual.Wang CengfangGao HanboyaLiu HuiTermedia Publishing Housearticleobesityblood pressureagedbiomarkeragingbiological ageMedicineRENArchives of Medical Science, Vol 16, Iss 1, Pp 129-134 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	obesity blood pressure aged biomarker aging biological age Medicine R
spellingShingle	obesity blood pressure aged biomarker aging biological age Medicine R Wang Cengfang Gao Hanboya Liu Hui Two-dimensional system based on organic and functional impairment with aging for precisely assessing risk factors in chronic disease
description	Introduction The aim of the study was to establish a two-dimensional system based on organic and functional biological age (BA) using a biomarker of organic and functional impairment with aging for precisely assessing roles of natural aging and other risk factors in chronic disease. Material and methods The index of organic mild impairment, which is similar to the frailty index, was determined with imaging parameters as organic BA. The functional BA was calculated with the following formula: Functional BA = [systolic – diastolic BP (mm Hg)] × waist circumference2 (m) × height0.5 (m)/weight (kg). A total of 1047 subjects undergoing routine health examination were randomly selected to establish a system with organic BA on the X-axis, functional BA on the Y-axis; organic and functional BAs from chronological age with 60 years as a center point of the coordinate system. A total of 85 patients with type 2 diabetes controls were recruited to verify the system. Results Organic and functional BA contributed to chronological age almost equally. Both organic and functional BA increased with chronological age in the two-dimensional system for a random population. There were significant difference for distribution between diabetes and control groups in two-dimensional system (p < 0.05). That both more in quadrant II and lesser in quadrant IV for diabetes were suggested that diabetes was more sensitive to other risk factors than aging. Conclusions Combination of the two BAs could precisely recognized aging and other risk factors according to locations of the disease in each quadrant and quantitatively assessed status of nature aging and disease-related aging in a individual.
format	article
author	Wang Cengfang Gao Hanboya Liu Hui
author_facet	Wang Cengfang Gao Hanboya Liu Hui
author_sort	Wang Cengfang
title	Two-dimensional system based on organic and functional impairment with aging for precisely assessing risk factors in chronic disease
title_short	Two-dimensional system based on organic and functional impairment with aging for precisely assessing risk factors in chronic disease
title_full	Two-dimensional system based on organic and functional impairment with aging for precisely assessing risk factors in chronic disease
title_fullStr	Two-dimensional system based on organic and functional impairment with aging for precisely assessing risk factors in chronic disease
title_full_unstemmed	Two-dimensional system based on organic and functional impairment with aging for precisely assessing risk factors in chronic disease
title_sort	two-dimensional system based on organic and functional impairment with aging for precisely assessing risk factors in chronic disease
publisher	Termedia Publishing House
publishDate	2019
url	https://doaj.org/article/617f5cf305354c478e381d3afbd416f1
work_keys_str_mv	AT wangcengfang twodimensionalsystembasedonorganicandfunctionalimpairmentwithagingforpreciselyassessingriskfactorsinchronicdisease AT gaohanboya twodimensionalsystembasedonorganicandfunctionalimpairmentwithagingforpreciselyassessingriskfactorsinchronicdisease AT liuhui twodimensionalsystembasedonorganicandfunctionalimpairmentwithagingforpreciselyassessingriskfactorsinchronicdisease
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Two-dimensional system based on organic and functional impairment with aging for precisely assessing risk factors in chronic disease

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