Structural basis for Epstein–Barr virus host cell tropism mediated by gp42 and gHgL entry glycoproteins

The entry of herpesviruses (such as Epstein-Barr virus) into host cells is mediated by a multitude of glycoproteins. Here, the authors show the structure of a viral glycoprotein complex, gHgL/gp42, bound to an anti-gHgL antibody, clarifying determinants of EBV host cell tropism.

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Autores principales:	Karthik Sathiyamoorthy, Yao Xiong Hu, Britta S. Möhl, Jia Chen, Richard Longnecker, Theodore S. Jardetzky
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/617fc14f4725440cbba95bd5665e779f
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spelling	oai:doaj.org-article:617fc14f4725440cbba95bd5665e779f2021-12-02T17:32:51ZStructural basis for Epstein–Barr virus host cell tropism mediated by gp42 and gHgL entry glycoproteins10.1038/ncomms135572041-1723https://doaj.org/article/617fc14f4725440cbba95bd5665e779f2016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13557https://doaj.org/toc/2041-1723The entry of herpesviruses (such as Epstein-Barr virus) into host cells is mediated by a multitude of glycoproteins. Here, the authors show the structure of a viral glycoprotein complex, gHgL/gp42, bound to an anti-gHgL antibody, clarifying determinants of EBV host cell tropism.Karthik SathiyamoorthyYao Xiong HuBritta S. MöhlJia ChenRichard LongneckerTheodore S. JardetzkyNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Karthik Sathiyamoorthy Yao Xiong Hu Britta S. Möhl Jia Chen Richard Longnecker Theodore S. Jardetzky Structural basis for Epstein–Barr virus host cell tropism mediated by gp42 and gHgL entry glycoproteins
description	The entry of herpesviruses (such as Epstein-Barr virus) into host cells is mediated by a multitude of glycoproteins. Here, the authors show the structure of a viral glycoprotein complex, gHgL/gp42, bound to an anti-gHgL antibody, clarifying determinants of EBV host cell tropism.
format	article
author	Karthik Sathiyamoorthy Yao Xiong Hu Britta S. Möhl Jia Chen Richard Longnecker Theodore S. Jardetzky
author_facet	Karthik Sathiyamoorthy Yao Xiong Hu Britta S. Möhl Jia Chen Richard Longnecker Theodore S. Jardetzky
author_sort	Karthik Sathiyamoorthy
title	Structural basis for Epstein–Barr virus host cell tropism mediated by gp42 and gHgL entry glycoproteins
title_short	Structural basis for Epstein–Barr virus host cell tropism mediated by gp42 and gHgL entry glycoproteins
title_full	Structural basis for Epstein–Barr virus host cell tropism mediated by gp42 and gHgL entry glycoproteins
title_fullStr	Structural basis for Epstein–Barr virus host cell tropism mediated by gp42 and gHgL entry glycoproteins
title_full_unstemmed	Structural basis for Epstein–Barr virus host cell tropism mediated by gp42 and gHgL entry glycoproteins
title_sort	structural basis for epstein–barr virus host cell tropism mediated by gp42 and ghgl entry glycoproteins
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/617fc14f4725440cbba95bd5665e779f
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Structural basis for Epstein–Barr virus host cell tropism mediated by gp42 and gHgL entry glycoproteins

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