Human evolved regulatory elements modulate genes involved in cortical expansion and neurodevelopmental disease susceptibility

Different classes of human evolved regulatory elements are located in non-coding regions of the genome. The authors connect the expansion of the cortical surface and connectivity with human evolved elements and show that their target genes are involved in neurodevelopmental disease susceptibility.

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Autores principales:	Hyejung Won, Jerry Huang, Carli K. Opland, Chris L. Hartl, Daniel H. Geschwind
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6180762705d944159131b08ebd485a49
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id	oai:doaj.org-article:6180762705d944159131b08ebd485a49
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spelling	oai:doaj.org-article:6180762705d944159131b08ebd485a492021-12-02T16:58:03ZHuman evolved regulatory elements modulate genes involved in cortical expansion and neurodevelopmental disease susceptibility10.1038/s41467-019-10248-32041-1723https://doaj.org/article/6180762705d944159131b08ebd485a492019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10248-3https://doaj.org/toc/2041-1723Different classes of human evolved regulatory elements are located in non-coding regions of the genome. The authors connect the expansion of the cortical surface and connectivity with human evolved elements and show that their target genes are involved in neurodevelopmental disease susceptibility.Hyejung WonJerry HuangCarli K. OplandChris L. HartlDaniel H. GeschwindNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hyejung Won Jerry Huang Carli K. Opland Chris L. Hartl Daniel H. Geschwind Human evolved regulatory elements modulate genes involved in cortical expansion and neurodevelopmental disease susceptibility
description	Different classes of human evolved regulatory elements are located in non-coding regions of the genome. The authors connect the expansion of the cortical surface and connectivity with human evolved elements and show that their target genes are involved in neurodevelopmental disease susceptibility.
format	article
author	Hyejung Won Jerry Huang Carli K. Opland Chris L. Hartl Daniel H. Geschwind
author_facet	Hyejung Won Jerry Huang Carli K. Opland Chris L. Hartl Daniel H. Geschwind
author_sort	Hyejung Won
title	Human evolved regulatory elements modulate genes involved in cortical expansion and neurodevelopmental disease susceptibility
title_short	Human evolved regulatory elements modulate genes involved in cortical expansion and neurodevelopmental disease susceptibility
title_full	Human evolved regulatory elements modulate genes involved in cortical expansion and neurodevelopmental disease susceptibility
title_fullStr	Human evolved regulatory elements modulate genes involved in cortical expansion and neurodevelopmental disease susceptibility
title_full_unstemmed	Human evolved regulatory elements modulate genes involved in cortical expansion and neurodevelopmental disease susceptibility
title_sort	human evolved regulatory elements modulate genes involved in cortical expansion and neurodevelopmental disease susceptibility
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/6180762705d944159131b08ebd485a49
work_keys_str_mv	AT hyejungwon humanevolvedregulatoryelementsmodulategenesinvolvedincorticalexpansionandneurodevelopmentaldiseasesusceptibility AT jerryhuang humanevolvedregulatoryelementsmodulategenesinvolvedincorticalexpansionandneurodevelopmentaldiseasesusceptibility AT carlikopland humanevolvedregulatoryelementsmodulategenesinvolvedincorticalexpansionandneurodevelopmentaldiseasesusceptibility AT chrislhartl humanevolvedregulatoryelementsmodulategenesinvolvedincorticalexpansionandneurodevelopmentaldiseasesusceptibility AT danielhgeschwind humanevolvedregulatoryelementsmodulategenesinvolvedincorticalexpansionandneurodevelopmentaldiseasesusceptibility
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Human evolved regulatory elements modulate genes involved in cortical expansion and neurodevelopmental disease susceptibility

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