A curated database of miRNA mediated feed-forward loops involving MYC as master regulator.

<h4>Background</h4>The MYC transcription factors are known to be involved in the biology of many human cancer types. But little is known about the Myc/microRNAs cooperation in the regulation of genes at the transcriptional and post-transcriptional level.<h4>Methodology/principal fi...

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Autores principales:	Mariama El Baroudi, Davide Corà, Carla Bosia, Matteo Osella, Michele Caselle
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/61843b5f0ace48eb8913bca03388a7e2
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id	oai:doaj.org-article:61843b5f0ace48eb8913bca03388a7e2
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spelling	oai:doaj.org-article:61843b5f0ace48eb8913bca03388a7e22021-11-18T06:57:51ZA curated database of miRNA mediated feed-forward loops involving MYC as master regulator.1932-620310.1371/journal.pone.0014742https://doaj.org/article/61843b5f0ace48eb8913bca03388a7e22011-03-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21390222/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The MYC transcription factors are known to be involved in the biology of many human cancer types. But little is known about the Myc/microRNAs cooperation in the regulation of genes at the transcriptional and post-transcriptional level.<h4>Methodology/principal findings</h4>Employing independent databases with experimentally validated data, we identified several mixed microRNA/Transcription Factor Feed-Forward Loops regulated by Myc and characterized completely by experimentally supported regulatory interactions, in human. We then studied the statistical and functional properties of these circuits and discussed in more detail a few interesting examples involving E2F1, PTEN, RB1 and VEGF.<h4>Conclusions/significance</h4>We have assembled and characterized a catalogue of human mixed Transcription Factor/microRNA Feed-Forward Loops, having Myc as master regulator and completely defined by experimentally verified regulatory interactions.Mariama El BaroudiDavide CoràCarla BosiaMatteo OsellaMichele CasellePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 3, p e14742 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mariama El Baroudi Davide Corà Carla Bosia Matteo Osella Michele Caselle A curated database of miRNA mediated feed-forward loops involving MYC as master regulator.
description	<h4>Background</h4>The MYC transcription factors are known to be involved in the biology of many human cancer types. But little is known about the Myc/microRNAs cooperation in the regulation of genes at the transcriptional and post-transcriptional level.<h4>Methodology/principal findings</h4>Employing independent databases with experimentally validated data, we identified several mixed microRNA/Transcription Factor Feed-Forward Loops regulated by Myc and characterized completely by experimentally supported regulatory interactions, in human. We then studied the statistical and functional properties of these circuits and discussed in more detail a few interesting examples involving E2F1, PTEN, RB1 and VEGF.<h4>Conclusions/significance</h4>We have assembled and characterized a catalogue of human mixed Transcription Factor/microRNA Feed-Forward Loops, having Myc as master regulator and completely defined by experimentally verified regulatory interactions.
format	article
author	Mariama El Baroudi Davide Corà Carla Bosia Matteo Osella Michele Caselle
author_facet	Mariama El Baroudi Davide Corà Carla Bosia Matteo Osella Michele Caselle
author_sort	Mariama El Baroudi
title	A curated database of miRNA mediated feed-forward loops involving MYC as master regulator.
title_short	A curated database of miRNA mediated feed-forward loops involving MYC as master regulator.
title_full	A curated database of miRNA mediated feed-forward loops involving MYC as master regulator.
title_fullStr	A curated database of miRNA mediated feed-forward loops involving MYC as master regulator.
title_full_unstemmed	A curated database of miRNA mediated feed-forward loops involving MYC as master regulator.
title_sort	curated database of mirna mediated feed-forward loops involving myc as master regulator.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/61843b5f0ace48eb8913bca03388a7e2
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A curated database of miRNA mediated feed-forward loops involving MYC as master regulator.

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