The Mitral INsufficiency Echocardiographic score: A severity classification of myxomatous mitral valve disease in dogs

Abstract Background There is no commonly shared severity score for myxomatous mitral valve disease (MMVD) based on routinely acquired echocardiographic variables. Hypothesis/Objectives To propose an easy‐to‐use echocardiographic classification of severity of MMVD in dogs. Animals Five hundred and si...

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Autores principales:	Tommaso Vezzosi, Giovanni Grosso, Rosalba Tognetti, Valentina Meucci, Valentina Patata, Federica Marchesotti, Oriol Domenech
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	cardiac death heart failure mitral regurgitation prognosis survival Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/61856758a99546a08c6426ad97663783
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spelling	oai:doaj.org-article:61856758a99546a08c6426ad976637832021-11-30T17:01:02ZThe Mitral INsufficiency Echocardiographic score: A severity classification of myxomatous mitral valve disease in dogs1939-16760891-664010.1111/jvim.16131https://doaj.org/article/61856758a99546a08c6426ad976637832021-05-01T00:00:00Zhttps://doi.org/10.1111/jvim.16131https://doaj.org/toc/0891-6640https://doaj.org/toc/1939-1676Abstract Background There is no commonly shared severity score for myxomatous mitral valve disease (MMVD) based on routinely acquired echocardiographic variables. Hypothesis/Objectives To propose an easy‐to‐use echocardiographic classification of severity of MMVD in dogs. Animals Five hundred and sixty dogs with MMVD. Methods This was a retrospective, multicenter, observational study. The proposed Mitral INsufficiency Echocardiographic (MINE) score was based on 4 echocardiographic variables: left atrium‐to‐aorta ratio, left ventricular end‐diastolic diameter normalized for body weight, fractional shortening, and E‐wave transmitral peak velocity. Specific echocardiographic cutoffs were defined based on previous prognostic studies on MMVD, and severity scores were assigned as follows: mild (score: 4‐5), moderate (score: 6‐7), severe (score: 8‐12), late stage (score: 13‐14). Results Median survival time was significantly different (P < .05) between the proposed severity classes: mild (2344 days, 95% confidence interval [CI] 1877‐2810 days), moderate (1882 days, 95% CI 1341‐2434 days), severe (623 days, 95% CI 432‐710 days), and late stage (157 days, 95% CI 53‐257 days). A MINE score >8 was predictive of cardiac death (area under the curve = 0.85; P < .0001; sensitivity 87%, specificity 73%). In the multivariable analysis, all the echocardiographic variables of the MINE score were independent predictors of death because of heart disease (P < .001). Conclusions and Clinical Importance The MINE score is a new easy‐to‐use echocardiographic classification of severity of MMVD, which has been proven to be clinically effective as it is associated with survival. This classification provides prognostic information and could be useful for an objective echocardiographic assessment of MMVD.Tommaso VezzosiGiovanni GrossoRosalba TognettiValentina MeucciValentina PatataFederica MarchesottiOriol DomenechWileyarticlecardiac deathheart failuremitral regurgitationprognosissurvivalVeterinary medicineSF600-1100ENJournal of Veterinary Internal Medicine, Vol 35, Iss 3, Pp 1238-1244 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cardiac death heart failure mitral regurgitation prognosis survival Veterinary medicine SF600-1100
spellingShingle	cardiac death heart failure mitral regurgitation prognosis survival Veterinary medicine SF600-1100 Tommaso Vezzosi Giovanni Grosso Rosalba Tognetti Valentina Meucci Valentina Patata Federica Marchesotti Oriol Domenech The Mitral INsufficiency Echocardiographic score: A severity classification of myxomatous mitral valve disease in dogs
description	Abstract Background There is no commonly shared severity score for myxomatous mitral valve disease (MMVD) based on routinely acquired echocardiographic variables. Hypothesis/Objectives To propose an easy‐to‐use echocardiographic classification of severity of MMVD in dogs. Animals Five hundred and sixty dogs with MMVD. Methods This was a retrospective, multicenter, observational study. The proposed Mitral INsufficiency Echocardiographic (MINE) score was based on 4 echocardiographic variables: left atrium‐to‐aorta ratio, left ventricular end‐diastolic diameter normalized for body weight, fractional shortening, and E‐wave transmitral peak velocity. Specific echocardiographic cutoffs were defined based on previous prognostic studies on MMVD, and severity scores were assigned as follows: mild (score: 4‐5), moderate (score: 6‐7), severe (score: 8‐12), late stage (score: 13‐14). Results Median survival time was significantly different (P < .05) between the proposed severity classes: mild (2344 days, 95% confidence interval [CI] 1877‐2810 days), moderate (1882 days, 95% CI 1341‐2434 days), severe (623 days, 95% CI 432‐710 days), and late stage (157 days, 95% CI 53‐257 days). A MINE score >8 was predictive of cardiac death (area under the curve = 0.85; P < .0001; sensitivity 87%, specificity 73%). In the multivariable analysis, all the echocardiographic variables of the MINE score were independent predictors of death because of heart disease (P < .001). Conclusions and Clinical Importance The MINE score is a new easy‐to‐use echocardiographic classification of severity of MMVD, which has been proven to be clinically effective as it is associated with survival. This classification provides prognostic information and could be useful for an objective echocardiographic assessment of MMVD.
format	article
author	Tommaso Vezzosi Giovanni Grosso Rosalba Tognetti Valentina Meucci Valentina Patata Federica Marchesotti Oriol Domenech
author_facet	Tommaso Vezzosi Giovanni Grosso Rosalba Tognetti Valentina Meucci Valentina Patata Federica Marchesotti Oriol Domenech
author_sort	Tommaso Vezzosi
title	The Mitral INsufficiency Echocardiographic score: A severity classification of myxomatous mitral valve disease in dogs
title_short	The Mitral INsufficiency Echocardiographic score: A severity classification of myxomatous mitral valve disease in dogs
title_full	The Mitral INsufficiency Echocardiographic score: A severity classification of myxomatous mitral valve disease in dogs
title_fullStr	The Mitral INsufficiency Echocardiographic score: A severity classification of myxomatous mitral valve disease in dogs
title_full_unstemmed	The Mitral INsufficiency Echocardiographic score: A severity classification of myxomatous mitral valve disease in dogs
title_sort	mitral insufficiency echocardiographic score: a severity classification of myxomatous mitral valve disease in dogs
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/61856758a99546a08c6426ad97663783
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The Mitral INsufficiency Echocardiographic score: A severity classification of myxomatous mitral valve disease in dogs

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