Stress-associated changes in salivary microRNAs can be detected in response to the Trier Social Stress Test: An exploratory study

Abstract Stress is an important co-factor for the genesis and maintenance of many diseases and is known to have an effect on gene expression via epigenetic regulation. MicroRNAs (miRNAs) appear to function as one of the key factors of this regulation. This is the first study to investigate the respo...

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Autores principales:	Conrad Wiegand, Peter Heusser, Claudia Klinger, Dirk Cysarz, Arndt Büssing, Thomas Ostermann, Andreas Savelsbergh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/61897889fafd414c80c561471e3031eb
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spelling	oai:doaj.org-article:61897889fafd414c80c561471e3031eb2021-12-02T15:08:55ZStress-associated changes in salivary microRNAs can be detected in response to the Trier Social Stress Test: An exploratory study10.1038/s41598-018-25554-x2045-2322https://doaj.org/article/61897889fafd414c80c561471e3031eb2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25554-xhttps://doaj.org/toc/2045-2322Abstract Stress is an important co-factor for the genesis and maintenance of many diseases and is known to have an effect on gene expression via epigenetic regulation. MicroRNAs (miRNAs) appear to function as one of the key factors of this regulation. This is the first study to investigate the response of 11 stress-associated miRNAs in human saliva - as a non-invasive source - in an experimental condition of acute psychological stress, and also their correlation with established psychological (subjective stress perception), physiological (heart rate and heart rate variability) and biochemical stress parameters (salivary cortisol and alpha-amylase). 24 healthy participants between 20 and 35 years of age were investigated, using the Trier Social Stress Test (TSST) to induce acute psychological stress. Stress-associated changes were significant for miR-20b, -21 and 26b, and changes in miR-16 and -134 were close to significance, recommending further research on these miRNAs in the context of stress reactions. Significant correlations with alpha-amylase suggest their integration in sympathetic stress regulation processes. Additionally, our results demonstrate the TSST as a reliable tool for studying salivary miRNAs as non-invasive indicators of epigenetic processes in acute psychological stress reactions.Conrad WiegandPeter HeusserClaudia KlingerDirk CysarzArndt BüssingThomas OstermannAndreas SavelsberghNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Conrad Wiegand Peter Heusser Claudia Klinger Dirk Cysarz Arndt Büssing Thomas Ostermann Andreas Savelsbergh Stress-associated changes in salivary microRNAs can be detected in response to the Trier Social Stress Test: An exploratory study
description	Abstract Stress is an important co-factor for the genesis and maintenance of many diseases and is known to have an effect on gene expression via epigenetic regulation. MicroRNAs (miRNAs) appear to function as one of the key factors of this regulation. This is the first study to investigate the response of 11 stress-associated miRNAs in human saliva - as a non-invasive source - in an experimental condition of acute psychological stress, and also their correlation with established psychological (subjective stress perception), physiological (heart rate and heart rate variability) and biochemical stress parameters (salivary cortisol and alpha-amylase). 24 healthy participants between 20 and 35 years of age were investigated, using the Trier Social Stress Test (TSST) to induce acute psychological stress. Stress-associated changes were significant for miR-20b, -21 and 26b, and changes in miR-16 and -134 were close to significance, recommending further research on these miRNAs in the context of stress reactions. Significant correlations with alpha-amylase suggest their integration in sympathetic stress regulation processes. Additionally, our results demonstrate the TSST as a reliable tool for studying salivary miRNAs as non-invasive indicators of epigenetic processes in acute psychological stress reactions.
format	article
author	Conrad Wiegand Peter Heusser Claudia Klinger Dirk Cysarz Arndt Büssing Thomas Ostermann Andreas Savelsbergh
author_facet	Conrad Wiegand Peter Heusser Claudia Klinger Dirk Cysarz Arndt Büssing Thomas Ostermann Andreas Savelsbergh
author_sort	Conrad Wiegand
title	Stress-associated changes in salivary microRNAs can be detected in response to the Trier Social Stress Test: An exploratory study
title_short	Stress-associated changes in salivary microRNAs can be detected in response to the Trier Social Stress Test: An exploratory study
title_full	Stress-associated changes in salivary microRNAs can be detected in response to the Trier Social Stress Test: An exploratory study
title_fullStr	Stress-associated changes in salivary microRNAs can be detected in response to the Trier Social Stress Test: An exploratory study
title_full_unstemmed	Stress-associated changes in salivary microRNAs can be detected in response to the Trier Social Stress Test: An exploratory study
title_sort	stress-associated changes in salivary micrornas can be detected in response to the trier social stress test: an exploratory study
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/61897889fafd414c80c561471e3031eb
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Stress-associated changes in salivary microRNAs can be detected in response to the Trier Social Stress Test: An exploratory study

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