Relationship between obesity-related anthropometric indicators and cognitive function in Chinese suburb-dwelling older adults

<h4>Background</h4> Studies relating obesity to cognition in older people show conflicting results, which may be explained by the choice of obesity indicators. <h4>Objectives</h4> This study aimed to investigate the relationship between obesity-related indicators and cognitiv...

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Autores principales: Weibo Ma, Hui Zhang, Ning Wu, Yuewen Liu, Peipei Han, Feng Wang, Jingru Wang, Fandi Xie, Shumeng Niu, Hao Hu, Chenyu Zhang, Nuo Chen, Yichen Zhang, Qi Guo, Ying Yu
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Publicado: Public Library of Science (PLoS) 2021
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Acceso en línea:https://doaj.org/article/618a7d7a31414c11a68bff24df9ca887
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spelling oai:doaj.org-article:618a7d7a31414c11a68bff24df9ca8872021-11-04T06:49:45ZRelationship between obesity-related anthropometric indicators and cognitive function in Chinese suburb-dwelling older adults1932-6203https://doaj.org/article/618a7d7a31414c11a68bff24df9ca8872021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8550380/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4> Studies relating obesity to cognition in older people show conflicting results, which may be explained by the choice of obesity indicators. <h4>Objectives</h4> This study aimed to investigate the relationship between obesity-related indicators and cognitive impairment, especially between different age or gender subgroups, and explore whether obesity-related indicators were related to specific cognitive domains. <h4>Methods</h4> This was a cross-sectional study on 1753 participants aged ≥ 60 years (41.0% men; aged 71.36 ± 5.96 years). Obesity-related indicators included body mass index (BMI), waist circumference (WC), calf circumference (CC), waist to hip ratio (WHR), waist to calf circumstance ratio (WCR), fat to fat-free mass ratio (FM/FFM). The Mini-Mental State Examination scale (MMSE) was used to assess cognitive function. Cognitive impairment was defined as a score ≤ 17 for illiterates, ≤ 20 for participants with primary school education, and ≤ 24 for those with junior high school degrees or above. Multiple logistic regression analysis was used to estimate multivariable-adjusted odds ratios (ORs) and 95% confidence intervals (CIs). Restricted cubic splines were used to analyze and visualize the linear relationships. <h4>Results</h4> The prevalence of cognitive impairment was 18.77%. In the fully adjusted model, CC was negatively associated with cognitive impairment (OR = 0.94, 95% CI: 0.90−0.98). Further analysis showed that CC correlated positively with recall and place orientation. A higher FM/FFM was found to be associated with a higher prevalence of cognitive impairment (OR: 1.44, 95%CI: 0.88–2.35, P for trend = 0.029); this association was notable in women (P for trend = 0.002) and the oldest (P for trend = 0.009), and so did the potential effect of BMI on cognitive impairment (70–80 years: P for trend = 0.011; ≥ 80 years: P for trend = 0.013). No statistically significant association was found between cognitive impairment and WC, WHR, or WCR. <h4>Conclusion</h4> CC and FM/FFM were associated with cognitive impairment in older people. Future research needs to distinguish the effects of fat and muscle mass on cognitive function, with special attention to different ages and genders.Weibo MaHui ZhangNing WuYuewen LiuPeipei HanFeng WangJingru WangFandi XieShumeng NiuHao HuChenyu ZhangNuo ChenYichen ZhangQi GuoYing YuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Weibo Ma
Hui Zhang
Ning Wu
Yuewen Liu
Peipei Han
Feng Wang
Jingru Wang
Fandi Xie
Shumeng Niu
Hao Hu
Chenyu Zhang
Nuo Chen
Yichen Zhang
Qi Guo
Ying Yu
Relationship between obesity-related anthropometric indicators and cognitive function in Chinese suburb-dwelling older adults
description <h4>Background</h4> Studies relating obesity to cognition in older people show conflicting results, which may be explained by the choice of obesity indicators. <h4>Objectives</h4> This study aimed to investigate the relationship between obesity-related indicators and cognitive impairment, especially between different age or gender subgroups, and explore whether obesity-related indicators were related to specific cognitive domains. <h4>Methods</h4> This was a cross-sectional study on 1753 participants aged ≥ 60 years (41.0% men; aged 71.36 ± 5.96 years). Obesity-related indicators included body mass index (BMI), waist circumference (WC), calf circumference (CC), waist to hip ratio (WHR), waist to calf circumstance ratio (WCR), fat to fat-free mass ratio (FM/FFM). The Mini-Mental State Examination scale (MMSE) was used to assess cognitive function. Cognitive impairment was defined as a score ≤ 17 for illiterates, ≤ 20 for participants with primary school education, and ≤ 24 for those with junior high school degrees or above. Multiple logistic regression analysis was used to estimate multivariable-adjusted odds ratios (ORs) and 95% confidence intervals (CIs). Restricted cubic splines were used to analyze and visualize the linear relationships. <h4>Results</h4> The prevalence of cognitive impairment was 18.77%. In the fully adjusted model, CC was negatively associated with cognitive impairment (OR = 0.94, 95% CI: 0.90−0.98). Further analysis showed that CC correlated positively with recall and place orientation. A higher FM/FFM was found to be associated with a higher prevalence of cognitive impairment (OR: 1.44, 95%CI: 0.88–2.35, P for trend = 0.029); this association was notable in women (P for trend = 0.002) and the oldest (P for trend = 0.009), and so did the potential effect of BMI on cognitive impairment (70–80 years: P for trend = 0.011; ≥ 80 years: P for trend = 0.013). No statistically significant association was found between cognitive impairment and WC, WHR, or WCR. <h4>Conclusion</h4> CC and FM/FFM were associated with cognitive impairment in older people. Future research needs to distinguish the effects of fat and muscle mass on cognitive function, with special attention to different ages and genders.
format article
author Weibo Ma
Hui Zhang
Ning Wu
Yuewen Liu
Peipei Han
Feng Wang
Jingru Wang
Fandi Xie
Shumeng Niu
Hao Hu
Chenyu Zhang
Nuo Chen
Yichen Zhang
Qi Guo
Ying Yu
author_facet Weibo Ma
Hui Zhang
Ning Wu
Yuewen Liu
Peipei Han
Feng Wang
Jingru Wang
Fandi Xie
Shumeng Niu
Hao Hu
Chenyu Zhang
Nuo Chen
Yichen Zhang
Qi Guo
Ying Yu
author_sort Weibo Ma
title Relationship between obesity-related anthropometric indicators and cognitive function in Chinese suburb-dwelling older adults
title_short Relationship between obesity-related anthropometric indicators and cognitive function in Chinese suburb-dwelling older adults
title_full Relationship between obesity-related anthropometric indicators and cognitive function in Chinese suburb-dwelling older adults
title_fullStr Relationship between obesity-related anthropometric indicators and cognitive function in Chinese suburb-dwelling older adults
title_full_unstemmed Relationship between obesity-related anthropometric indicators and cognitive function in Chinese suburb-dwelling older adults
title_sort relationship between obesity-related anthropometric indicators and cognitive function in chinese suburb-dwelling older adults
publisher Public Library of Science (PLoS)
publishDate 2021
url https://doaj.org/article/618a7d7a31414c11a68bff24df9ca887
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