BLM helicase suppresses recombination at G-quadruplex motifs in transcribed genes

Bloom syndrome is characterized by high levels of sister chromatid exchanges (SCEs). Here, the authors use single-cell DNA template strand-sequencing to map SCEs in patient cells, and propose that the BLM helicase protects the genome against unwanted recombination at sites of G-quadruplex structures...

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Autores principales:	Niek van Wietmarschen, Sarra Merzouk, Nancy Halsema, Diana C. J. Spierings, Victor Guryev, Peter M. Lansdorp
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/618abfc1bc384381bf8da07ccfc3f7a1
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spelling	oai:doaj.org-article:618abfc1bc384381bf8da07ccfc3f7a12021-12-02T14:39:26ZBLM helicase suppresses recombination at G-quadruplex motifs in transcribed genes10.1038/s41467-017-02760-12041-1723https://doaj.org/article/618abfc1bc384381bf8da07ccfc3f7a12018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02760-1https://doaj.org/toc/2041-1723Bloom syndrome is characterized by high levels of sister chromatid exchanges (SCEs). Here, the authors use single-cell DNA template strand-sequencing to map SCEs in patient cells, and propose that the BLM helicase protects the genome against unwanted recombination at sites of G-quadruplex structures.Niek van WietmarschenSarra MerzoukNancy HalsemaDiana C. J. SpieringsVictor GuryevPeter M. LansdorpNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Niek van Wietmarschen Sarra Merzouk Nancy Halsema Diana C. J. Spierings Victor Guryev Peter M. Lansdorp BLM helicase suppresses recombination at G-quadruplex motifs in transcribed genes
description	Bloom syndrome is characterized by high levels of sister chromatid exchanges (SCEs). Here, the authors use single-cell DNA template strand-sequencing to map SCEs in patient cells, and propose that the BLM helicase protects the genome against unwanted recombination at sites of G-quadruplex structures.
format	article
author	Niek van Wietmarschen Sarra Merzouk Nancy Halsema Diana C. J. Spierings Victor Guryev Peter M. Lansdorp
author_facet	Niek van Wietmarschen Sarra Merzouk Nancy Halsema Diana C. J. Spierings Victor Guryev Peter M. Lansdorp
author_sort	Niek van Wietmarschen
title	BLM helicase suppresses recombination at G-quadruplex motifs in transcribed genes
title_short	BLM helicase suppresses recombination at G-quadruplex motifs in transcribed genes
title_full	BLM helicase suppresses recombination at G-quadruplex motifs in transcribed genes
title_fullStr	BLM helicase suppresses recombination at G-quadruplex motifs in transcribed genes
title_full_unstemmed	BLM helicase suppresses recombination at G-quadruplex motifs in transcribed genes
title_sort	blm helicase suppresses recombination at g-quadruplex motifs in transcribed genes
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/618abfc1bc384381bf8da07ccfc3f7a1
work_keys_str_mv	AT niekvanwietmarschen blmhelicasesuppressesrecombinationatgquadruplexmotifsintranscribedgenes AT sarramerzouk blmhelicasesuppressesrecombinationatgquadruplexmotifsintranscribedgenes AT nancyhalsema blmhelicasesuppressesrecombinationatgquadruplexmotifsintranscribedgenes AT dianacjspierings blmhelicasesuppressesrecombinationatgquadruplexmotifsintranscribedgenes AT victorguryev blmhelicasesuppressesrecombinationatgquadruplexmotifsintranscribedgenes AT petermlansdorp blmhelicasesuppressesrecombinationatgquadruplexmotifsintranscribedgenes
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BLM helicase suppresses recombination at G-quadruplex motifs in transcribed genes

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