Scotopic thresholds on dark-adapted chromatic perimetry in healthy aging and age-related macular degeneration

Abstract To evaluate the effect of aging, intra- and intersession repeatability and regional scotopic sensitivities in healthy and age-related macular degeneration (AMD) eyes. Intra- and intersession agreement and effect of age was measured in healthy individuals. The mean sensitivity (MS) and point...

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Autores principales:	Manjot Kaur Grewal, Shruti Chandra, Alan Bird, Glen Jeffery, Sobha Sivaprasad
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/618ebfba341e47b580b3b73686763930
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spelling	oai:doaj.org-article:618ebfba341e47b580b3b736867639302021-12-02T16:50:36ZScotopic thresholds on dark-adapted chromatic perimetry in healthy aging and age-related macular degeneration10.1038/s41598-021-89677-42045-2322https://doaj.org/article/618ebfba341e47b580b3b736867639302021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89677-4https://doaj.org/toc/2045-2322Abstract To evaluate the effect of aging, intra- and intersession repeatability and regional scotopic sensitivities in healthy and age-related macular degeneration (AMD) eyes. Intra- and intersession agreement and effect of age was measured in healthy individuals. The mean sensitivity (MS) and pointwise retinal sensitivities (PWS) within the central 24° with 505 nm (cyan) and 625 nm (red) stimuli were evaluated in 50 individuals (11 healthy and 39 AMD eyes). The overall intra- and intersession had excellent reliability (intraclass correlation coefficient, ICC > 0.90) and tests were highly correlated (Spearman rs = 0.75–0.86). Eyes with subretinal drusenoid deposit (SDD) had reduced PWS centrally, particularly at inferior and nasal retinal locations compared with controls and intermediate AMD (iAMD) without SDD. There was no difference in MS or PWS at any retinal location between iAMD without SDD and healthy individuals nor between iAMD with SDD and non-foveal atrophic AMD groups. Eyes with SDD have reduced rod function compared to iAMD without SDD and healthy eyes, but similar to eyes with non-foveal atrophy. Our results highlight rod dysfunction is not directly correlated with drusen load and SDD location.Manjot Kaur GrewalShruti ChandraAlan BirdGlen JefferySobha SivaprasadNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Manjot Kaur Grewal Shruti Chandra Alan Bird Glen Jeffery Sobha Sivaprasad Scotopic thresholds on dark-adapted chromatic perimetry in healthy aging and age-related macular degeneration
description	Abstract To evaluate the effect of aging, intra- and intersession repeatability and regional scotopic sensitivities in healthy and age-related macular degeneration (AMD) eyes. Intra- and intersession agreement and effect of age was measured in healthy individuals. The mean sensitivity (MS) and pointwise retinal sensitivities (PWS) within the central 24° with 505 nm (cyan) and 625 nm (red) stimuli were evaluated in 50 individuals (11 healthy and 39 AMD eyes). The overall intra- and intersession had excellent reliability (intraclass correlation coefficient, ICC > 0.90) and tests were highly correlated (Spearman rs = 0.75–0.86). Eyes with subretinal drusenoid deposit (SDD) had reduced PWS centrally, particularly at inferior and nasal retinal locations compared with controls and intermediate AMD (iAMD) without SDD. There was no difference in MS or PWS at any retinal location between iAMD without SDD and healthy individuals nor between iAMD with SDD and non-foveal atrophic AMD groups. Eyes with SDD have reduced rod function compared to iAMD without SDD and healthy eyes, but similar to eyes with non-foveal atrophy. Our results highlight rod dysfunction is not directly correlated with drusen load and SDD location.
format	article
author	Manjot Kaur Grewal Shruti Chandra Alan Bird Glen Jeffery Sobha Sivaprasad
author_facet	Manjot Kaur Grewal Shruti Chandra Alan Bird Glen Jeffery Sobha Sivaprasad
author_sort	Manjot Kaur Grewal
title	Scotopic thresholds on dark-adapted chromatic perimetry in healthy aging and age-related macular degeneration
title_short	Scotopic thresholds on dark-adapted chromatic perimetry in healthy aging and age-related macular degeneration
title_full	Scotopic thresholds on dark-adapted chromatic perimetry in healthy aging and age-related macular degeneration
title_fullStr	Scotopic thresholds on dark-adapted chromatic perimetry in healthy aging and age-related macular degeneration
title_full_unstemmed	Scotopic thresholds on dark-adapted chromatic perimetry in healthy aging and age-related macular degeneration
title_sort	scotopic thresholds on dark-adapted chromatic perimetry in healthy aging and age-related macular degeneration
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/618ebfba341e47b580b3b73686763930
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Scotopic thresholds on dark-adapted chromatic perimetry in healthy aging and age-related macular degeneration

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