MyD88 promotes myoblast fusion in a cell-autonomous manner

Myoblast fusion is essential for skeletal muscle development and regeneration. Here the authors show that MyD88 is upregulated during myogenesis and during muscle growth, signals via the NF-κB and Wnt pathways, and that its expression modulates myoblast fusion and myofiber size in mice.

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Autores principales:	Sajedah M. Hindi, Jonghyun Shin, Yann S. Gallot, Alex R. Straughn, Adriana Simionescu-Bankston, Lubna Hindi, Guangyan Xiong, Robert P. Friedland, Ashok Kumar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/618fe52d57e34274978244f35c4dbdb6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:618fe52d57e34274978244f35c4dbdb62021-12-02T14:41:58ZMyD88 promotes myoblast fusion in a cell-autonomous manner10.1038/s41467-017-01866-w2041-1723https://doaj.org/article/618fe52d57e34274978244f35c4dbdb62017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01866-whttps://doaj.org/toc/2041-1723Myoblast fusion is essential for skeletal muscle development and regeneration. Here the authors show that MyD88 is upregulated during myogenesis and during muscle growth, signals via the NF-κB and Wnt pathways, and that its expression modulates myoblast fusion and myofiber size in mice.Sajedah M. HindiJonghyun ShinYann S. GallotAlex R. StraughnAdriana Simionescu-BankstonLubna HindiGuangyan XiongRobert P. FriedlandAshok KumarNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sajedah M. Hindi Jonghyun Shin Yann S. Gallot Alex R. Straughn Adriana Simionescu-Bankston Lubna Hindi Guangyan Xiong Robert P. Friedland Ashok Kumar MyD88 promotes myoblast fusion in a cell-autonomous manner
description	Myoblast fusion is essential for skeletal muscle development and regeneration. Here the authors show that MyD88 is upregulated during myogenesis and during muscle growth, signals via the NF-κB and Wnt pathways, and that its expression modulates myoblast fusion and myofiber size in mice.
format	article
author	Sajedah M. Hindi Jonghyun Shin Yann S. Gallot Alex R. Straughn Adriana Simionescu-Bankston Lubna Hindi Guangyan Xiong Robert P. Friedland Ashok Kumar
author_facet	Sajedah M. Hindi Jonghyun Shin Yann S. Gallot Alex R. Straughn Adriana Simionescu-Bankston Lubna Hindi Guangyan Xiong Robert P. Friedland Ashok Kumar
author_sort	Sajedah M. Hindi
title	MyD88 promotes myoblast fusion in a cell-autonomous manner
title_short	MyD88 promotes myoblast fusion in a cell-autonomous manner
title_full	MyD88 promotes myoblast fusion in a cell-autonomous manner
title_fullStr	MyD88 promotes myoblast fusion in a cell-autonomous manner
title_full_unstemmed	MyD88 promotes myoblast fusion in a cell-autonomous manner
title_sort	myd88 promotes myoblast fusion in a cell-autonomous manner
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/618fe52d57e34274978244f35c4dbdb6
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MyD88 promotes myoblast fusion in a cell-autonomous manner

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