RIG-I like receptor sensing of host RNAs facilitates the cell-intrinsic immune response to KSHV infection
RIG-I and MDA5, are cytosolic restriction factors and receptors for RNA viruses. Here the authors show during KSHV lytic infection that substrates for recognition by RIG-I and MDA5 are misprocessed RNAs derived from noncoding host RNA molecules, suggesting antiviral immunity can be engaged by sensin...
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| Autores principales: | , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2018
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/6190bab07a2545dbac95648005720f8c |
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| Sumario: | RIG-I and MDA5, are cytosolic restriction factors and receptors for RNA viruses. Here the authors show during KSHV lytic infection that substrates for recognition by RIG-I and MDA5 are misprocessed RNAs derived from noncoding host RNA molecules, suggesting antiviral immunity can be engaged by sensing of misprocessed cellular RNAs. |
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