RIG-I like receptor sensing of host RNAs facilitates the cell-intrinsic immune response to KSHV infection

RIG-I and MDA5, are cytosolic restriction factors and receptors for RNA viruses. Here the authors show during KSHV lytic infection that substrates for recognition by RIG-I and MDA5 are misprocessed RNAs derived from noncoding host RNA molecules, suggesting antiviral immunity can be engaged by sensin...

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Autores principales:	Yang Zhao, Xiang Ye, William Dunker, Yu Song, John Karijolich
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6190bab07a2545dbac95648005720f8c
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spelling	oai:doaj.org-article:6190bab07a2545dbac95648005720f8c2021-12-02T15:34:27ZRIG-I like receptor sensing of host RNAs facilitates the cell-intrinsic immune response to KSHV infection10.1038/s41467-018-07314-72041-1723https://doaj.org/article/6190bab07a2545dbac95648005720f8c2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07314-7https://doaj.org/toc/2041-1723RIG-I and MDA5, are cytosolic restriction factors and receptors for RNA viruses. Here the authors show during KSHV lytic infection that substrates for recognition by RIG-I and MDA5 are misprocessed RNAs derived from noncoding host RNA molecules, suggesting antiviral immunity can be engaged by sensing of misprocessed cellular RNAs.Yang ZhaoXiang YeWilliam DunkerYu SongJohn KarijolichNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yang Zhao Xiang Ye William Dunker Yu Song John Karijolich RIG-I like receptor sensing of host RNAs facilitates the cell-intrinsic immune response to KSHV infection
description	RIG-I and MDA5, are cytosolic restriction factors and receptors for RNA viruses. Here the authors show during KSHV lytic infection that substrates for recognition by RIG-I and MDA5 are misprocessed RNAs derived from noncoding host RNA molecules, suggesting antiviral immunity can be engaged by sensing of misprocessed cellular RNAs.
format	article
author	Yang Zhao Xiang Ye William Dunker Yu Song John Karijolich
author_facet	Yang Zhao Xiang Ye William Dunker Yu Song John Karijolich
author_sort	Yang Zhao
title	RIG-I like receptor sensing of host RNAs facilitates the cell-intrinsic immune response to KSHV infection
title_short	RIG-I like receptor sensing of host RNAs facilitates the cell-intrinsic immune response to KSHV infection
title_full	RIG-I like receptor sensing of host RNAs facilitates the cell-intrinsic immune response to KSHV infection
title_fullStr	RIG-I like receptor sensing of host RNAs facilitates the cell-intrinsic immune response to KSHV infection
title_full_unstemmed	RIG-I like receptor sensing of host RNAs facilitates the cell-intrinsic immune response to KSHV infection
title_sort	rig-i like receptor sensing of host rnas facilitates the cell-intrinsic immune response to kshv infection
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/6190bab07a2545dbac95648005720f8c
work_keys_str_mv	AT yangzhao rigilikereceptorsensingofhostrnasfacilitatesthecellintrinsicimmuneresponsetokshvinfection AT xiangye rigilikereceptorsensingofhostrnasfacilitatesthecellintrinsicimmuneresponsetokshvinfection AT williamdunker rigilikereceptorsensingofhostrnasfacilitatesthecellintrinsicimmuneresponsetokshvinfection AT yusong rigilikereceptorsensingofhostrnasfacilitatesthecellintrinsicimmuneresponsetokshvinfection AT johnkarijolich rigilikereceptorsensingofhostrnasfacilitatesthecellintrinsicimmuneresponsetokshvinfection
_version_	1718386839787667456

RIG-I like receptor sensing of host RNAs facilitates the cell-intrinsic immune response to KSHV infection

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