Impact of 12-week exercise program on biomarkers of gut barrier integrity in patients with coronary artery disease.

<h4>Introduction</h4>Breakdown of gut barrier integrity has been associated with inflammatory activation and is implicated in the etiology of several chronic medical conditions. Acute exercise is known to increase gut barrier permeability but the impact of chronic exercise is not clear....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Vivian Feng, Kritleen K Bawa, Susan Marzolini, Alex Kiss, Paul Oh, Nathan Herrmann, Krista L Lanctôt, Damien Gallagher
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/619f75534bfd414db3e0cb0577add66c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:619f75534bfd414db3e0cb0577add66c
record_format	dspace
spelling	oai:doaj.org-article:619f75534bfd414db3e0cb0577add66c2021-12-02T20:12:37ZImpact of 12-week exercise program on biomarkers of gut barrier integrity in patients with coronary artery disease.1932-620310.1371/journal.pone.0260165https://doaj.org/article/619f75534bfd414db3e0cb0577add66c2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0260165https://doaj.org/toc/1932-6203<h4>Introduction</h4>Breakdown of gut barrier integrity has been associated with inflammatory activation and is implicated in the etiology of several chronic medical conditions. Acute exercise is known to increase gut barrier permeability but the impact of chronic exercise is not clear. Most studies to date have examined how acute exercise impacts gut barrier integrity in healthy adults, while few studies have examined the impact of chronic exercise in older adults with comorbidities. We aim to investigate the impact of a 12-week program of aerobic and resistance training on biomarkers of gut barrier integrity in a sample of older adults with coronary artery disease.<h4>Methods</h4>Participants were adults with coronary artery disease undergoing a moderate-intensity 12-week cardiac rehabilitation exercise program. Fasting blood samples were taken at baseline and study termination. Serum levels of biomarkers of gut barrier integrity (zonulin and fatty acid-binding protein 2 (FABP2)) were measured by ELISA. Cardiorespiratory fitness was assessed by peak oxygen uptake (VO2peak) at study start & completion. Data analyses were performed using SPSS software version 24.0.<h4>Results</h4>Among study participants (n = 41, 70% male, age = 62.7± 9.35) we found a significant negative association between baseline FABP2 levels and baseline VO2peak in a multiple linear regression model adjusting for covariates (B = -0.3, p = 0.009). Over the course of the exercise program an increase in VO2peak (≥ 5 mL/kg/min) was independently associated with a relative decrease in FABP2 (B = -0.45, p = 0.018) after controlling for medical covariates.<h4>Conclusion</h4>Our findings indicate that an increase in cardiorespiratory fitness during a 12-week exercise program resulted in a relative improvement in a biomarker of gut barrier integrity. This indicates a potential mechanism by which longer term exercise may improve gut barrier integrity.Vivian FengKritleen K BawaSusan MarzoliniAlex KissPaul OhNathan HerrmannKrista L LanctôtDamien GallagherPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0260165 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Vivian Feng Kritleen K Bawa Susan Marzolini Alex Kiss Paul Oh Nathan Herrmann Krista L Lanctôt Damien Gallagher Impact of 12-week exercise program on biomarkers of gut barrier integrity in patients with coronary artery disease.
description	<h4>Introduction</h4>Breakdown of gut barrier integrity has been associated with inflammatory activation and is implicated in the etiology of several chronic medical conditions. Acute exercise is known to increase gut barrier permeability but the impact of chronic exercise is not clear. Most studies to date have examined how acute exercise impacts gut barrier integrity in healthy adults, while few studies have examined the impact of chronic exercise in older adults with comorbidities. We aim to investigate the impact of a 12-week program of aerobic and resistance training on biomarkers of gut barrier integrity in a sample of older adults with coronary artery disease.<h4>Methods</h4>Participants were adults with coronary artery disease undergoing a moderate-intensity 12-week cardiac rehabilitation exercise program. Fasting blood samples were taken at baseline and study termination. Serum levels of biomarkers of gut barrier integrity (zonulin and fatty acid-binding protein 2 (FABP2)) were measured by ELISA. Cardiorespiratory fitness was assessed by peak oxygen uptake (VO2peak) at study start & completion. Data analyses were performed using SPSS software version 24.0.<h4>Results</h4>Among study participants (n = 41, 70% male, age = 62.7± 9.35) we found a significant negative association between baseline FABP2 levels and baseline VO2peak in a multiple linear regression model adjusting for covariates (B = -0.3, p = 0.009). Over the course of the exercise program an increase in VO2peak (≥ 5 mL/kg/min) was independently associated with a relative decrease in FABP2 (B = -0.45, p = 0.018) after controlling for medical covariates.<h4>Conclusion</h4>Our findings indicate that an increase in cardiorespiratory fitness during a 12-week exercise program resulted in a relative improvement in a biomarker of gut barrier integrity. This indicates a potential mechanism by which longer term exercise may improve gut barrier integrity.
format	article
author	Vivian Feng Kritleen K Bawa Susan Marzolini Alex Kiss Paul Oh Nathan Herrmann Krista L Lanctôt Damien Gallagher
author_facet	Vivian Feng Kritleen K Bawa Susan Marzolini Alex Kiss Paul Oh Nathan Herrmann Krista L Lanctôt Damien Gallagher
author_sort	Vivian Feng
title	Impact of 12-week exercise program on biomarkers of gut barrier integrity in patients with coronary artery disease.
title_short	Impact of 12-week exercise program on biomarkers of gut barrier integrity in patients with coronary artery disease.
title_full	Impact of 12-week exercise program on biomarkers of gut barrier integrity in patients with coronary artery disease.
title_fullStr	Impact of 12-week exercise program on biomarkers of gut barrier integrity in patients with coronary artery disease.
title_full_unstemmed	Impact of 12-week exercise program on biomarkers of gut barrier integrity in patients with coronary artery disease.
title_sort	impact of 12-week exercise program on biomarkers of gut barrier integrity in patients with coronary artery disease.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/619f75534bfd414db3e0cb0577add66c
work_keys_str_mv	AT vivianfeng impactof12weekexerciseprogramonbiomarkersofgutbarrierintegrityinpatientswithcoronaryarterydisease AT kritleenkbawa impactof12weekexerciseprogramonbiomarkersofgutbarrierintegrityinpatientswithcoronaryarterydisease AT susanmarzolini impactof12weekexerciseprogramonbiomarkersofgutbarrierintegrityinpatientswithcoronaryarterydisease AT alexkiss impactof12weekexerciseprogramonbiomarkersofgutbarrierintegrityinpatientswithcoronaryarterydisease AT pauloh impactof12weekexerciseprogramonbiomarkersofgutbarrierintegrityinpatientswithcoronaryarterydisease AT nathanherrmann impactof12weekexerciseprogramonbiomarkersofgutbarrierintegrityinpatientswithcoronaryarterydisease AT kristallanctot impactof12weekexerciseprogramonbiomarkersofgutbarrierintegrityinpatientswithcoronaryarterydisease AT damiengallagher impactof12weekexerciseprogramonbiomarkersofgutbarrierintegrityinpatientswithcoronaryarterydisease
_version_	1718374888162459648

Impact of 12-week exercise program on biomarkers of gut barrier integrity in patients with coronary artery disease.

Ejemplares similares