ARMC Subfamily: Structures, Functions, Evolutions, Interactions, and Diseases

Armadillo repeat-containing proteins (ARMCs) are widely distributed in eukaryotes and have important influences on cell adhesion, signal transduction, mitochondrial function regulation, tumorigenesis, and other processes. These proteins share a similar domain consisting of tandem repeats approximate...

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Autores principales:	Yutao Huang, Zijian Jiang, Xiangyu Gao, Peng Luo, Xiaofan Jiang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Armadillo repeat-containing protein ARMC structure biological function evolution interaction Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/61a007c8db1b41afbc49069001dc9f54
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id	oai:doaj.org-article:61a007c8db1b41afbc49069001dc9f54
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spelling	oai:doaj.org-article:61a007c8db1b41afbc49069001dc9f542021-12-01T12:16:40ZARMC Subfamily: Structures, Functions, Evolutions, Interactions, and Diseases2296-889X10.3389/fmolb.2021.791597https://doaj.org/article/61a007c8db1b41afbc49069001dc9f542021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmolb.2021.791597/fullhttps://doaj.org/toc/2296-889XArmadillo repeat-containing proteins (ARMCs) are widely distributed in eukaryotes and have important influences on cell adhesion, signal transduction, mitochondrial function regulation, tumorigenesis, and other processes. These proteins share a similar domain consisting of tandem repeats approximately 42 amino acids in length, and this domain constitutes a substantial platform for the binding between ARMCs and other proteins. An ARMC subfamily, including ARMC1∼10, ARMC12, and ARMCX1∼6, has received increasing attention. These proteins may have many terminal regions and play a critical role in various diseases. On the one hand, based on their similar central domain of tandem repeats, this ARMC subfamily may function similarly to other ARMCs. On the other hand, the unique domains on their terminals may cause these proteins to have different functions. Here, we focus on the ARMC subfamily (ARMC1∼10, ARMC12, and ARMCX1∼6), which is relatively conserved in vertebrates and highly conserved in mammals, particularly primates. We review the structures, biological functions, evolutions, interactions, and related diseases of the ARMC subfamily, which involve more than 30 diseases and 40 bypasses, including interactions and relationships between more than 100 proteins and signaling molecules. We look forward to obtaining a clearer understanding of the ARMC subfamily to facilitate further in-depth research and treatment of related diseases.Yutao HuangYutao HuangZijian JiangXiangyu GaoXiangyu GaoPeng LuoPeng LuoXiaofan JiangXiaofan JiangFrontiers Media S.A.articleArmadillo repeat-containing proteinARMCstructurebiological functionevolutioninteractionBiology (General)QH301-705.5ENFrontiers in Molecular Biosciences, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Armadillo repeat-containing protein ARMC structure biological function evolution interaction Biology (General) QH301-705.5
spellingShingle	Armadillo repeat-containing protein ARMC structure biological function evolution interaction Biology (General) QH301-705.5 Yutao Huang Yutao Huang Zijian Jiang Xiangyu Gao Xiangyu Gao Peng Luo Peng Luo Xiaofan Jiang Xiaofan Jiang ARMC Subfamily: Structures, Functions, Evolutions, Interactions, and Diseases
description	Armadillo repeat-containing proteins (ARMCs) are widely distributed in eukaryotes and have important influences on cell adhesion, signal transduction, mitochondrial function regulation, tumorigenesis, and other processes. These proteins share a similar domain consisting of tandem repeats approximately 42 amino acids in length, and this domain constitutes a substantial platform for the binding between ARMCs and other proteins. An ARMC subfamily, including ARMC1∼10, ARMC12, and ARMCX1∼6, has received increasing attention. These proteins may have many terminal regions and play a critical role in various diseases. On the one hand, based on their similar central domain of tandem repeats, this ARMC subfamily may function similarly to other ARMCs. On the other hand, the unique domains on their terminals may cause these proteins to have different functions. Here, we focus on the ARMC subfamily (ARMC1∼10, ARMC12, and ARMCX1∼6), which is relatively conserved in vertebrates and highly conserved in mammals, particularly primates. We review the structures, biological functions, evolutions, interactions, and related diseases of the ARMC subfamily, which involve more than 30 diseases and 40 bypasses, including interactions and relationships between more than 100 proteins and signaling molecules. We look forward to obtaining a clearer understanding of the ARMC subfamily to facilitate further in-depth research and treatment of related diseases.
format	article
author	Yutao Huang Yutao Huang Zijian Jiang Xiangyu Gao Xiangyu Gao Peng Luo Peng Luo Xiaofan Jiang Xiaofan Jiang
author_facet	Yutao Huang Yutao Huang Zijian Jiang Xiangyu Gao Xiangyu Gao Peng Luo Peng Luo Xiaofan Jiang Xiaofan Jiang
author_sort	Yutao Huang
title	ARMC Subfamily: Structures, Functions, Evolutions, Interactions, and Diseases
title_short	ARMC Subfamily: Structures, Functions, Evolutions, Interactions, and Diseases
title_full	ARMC Subfamily: Structures, Functions, Evolutions, Interactions, and Diseases
title_fullStr	ARMC Subfamily: Structures, Functions, Evolutions, Interactions, and Diseases
title_full_unstemmed	ARMC Subfamily: Structures, Functions, Evolutions, Interactions, and Diseases
title_sort	armc subfamily: structures, functions, evolutions, interactions, and diseases
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/61a007c8db1b41afbc49069001dc9f54
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ARMC Subfamily: Structures, Functions, Evolutions, Interactions, and Diseases

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