FEATURES OF SYSTEM IMMUNITY IN WOMEN WITH ENDOMETRIOSIS AND GENITAL INFECTION

External genital endometriosis is an inflammatory, estrogen-dependent disease that develops predominantly in women of reproductive age and is characterized by the presence of pain syndrome and infertility. Today, endometriosis is one of the most common gynecological diseases in women of reproductive...

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Autores principales:	L. F. Zaynetdinova, L. F. Telesheva, A. V. Koryaushkina, S. V. Kvyatkovskaya, E. A. Mezenceva, K. V. Nikushkina
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2019
Materias:	external genital endometriosis systemic immunity human papillomavirus of high oncogenic risk ureaplasma infection Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/61a2e5665719401f8a3b39d7df868277
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spelling	oai:doaj.org-article:61a2e5665719401f8a3b39d7df8682772021-11-18T08:03:49ZFEATURES OF SYSTEM IMMUNITY IN WOMEN WITH ENDOMETRIOSIS AND GENITAL INFECTION1563-06252313-741X10.15789/1563-0625-2019-5-895-910https://doaj.org/article/61a2e5665719401f8a3b39d7df8682772019-12-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1763https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XExternal genital endometriosis is an inflammatory, estrogen-dependent disease that develops predominantly in women of reproductive age and is characterized by the presence of pain syndrome and infertility. Today, endometriosis is one of the most common gynecological diseases in women of reproductive age, however, the etiology and pathogenesis of it are not completely clear. Violations of systemic immunity are most important in the pathogenesis of endometriosis. The literature data on the features of the immune response in endometriosis in combination with genital infection are few and contradictory. Purpose – to study the features of systemic immunity in women with external genital endometriosis and pathogens of genital infection.A total of 159 women with external genital endometriosis were examined. The main lymphocyte subpopulations, the functional activity of neutrophils and peripheral blood monocytes, and the content of cytokines in the blood serum were studied. A study of systemic immunity was performed in women with 1-2 and 3-4 stages of endometriosis, as well as depending on the presence of pathogens of genital infection. The presence of Chlamydia trachomatis, Ureaplasma spp., Mycoplasma genitalium, HSV1, 2/CMV, HPV in the endometrium, peritoneal fluid, and endometrioid heterotopies was determined. Statistical processing was performed using the IBM SPSS Statistics Version 22.2 statistical analysis software package.According to the results of the study, it was found that women with endometriosis of stages 1-2 show signs of systemic inflammation with a predominance of the Th2 type of immune response and inhibition of cellular immunity. A particular feature of HPV was an increase in T-NK lymphocytes, a decrease in IL-2 and neutrophil functional activity. The presence of Ureaplasma spp./Mycoplasma genitalium was characterized by a decrease in cellular immunity and an increase in T-NK cells. Only with HPV and Ureaplasma spp./Mycoplasma genitalium decreased synthesis of IL-2, IL-6. With 3-4 stages, the most significant changes in immunity were found in groups of women with genital infection. When HPV – a high level of IgA, increased IgM, IL-8. With Ureaplasma spp./Mycoplasma genitalium – inhibition of cellular immunity, high levels of IgA, reduction of neutrophil phagocytic activity.Thus, in women with endometriosis in the presence of pathogens of genital infection revealed features that may contribute to the development and progression of the disease.L. F. ZaynetdinovaL. F. TeleshevaA. V. KoryaushkinaS. V. KvyatkovskayaE. A. MezencevaK. V. NikushkinaSPb RAACIarticleexternal genital endometriosissystemic immunityhuman papillomavirus of high oncogenic riskureaplasma infectionImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 21, Iss 5, Pp 895-910 (2019)
institution	DOAJ
collection	DOAJ
language	RU
topic	external genital endometriosis systemic immunity human papillomavirus of high oncogenic risk ureaplasma infection Immunologic diseases. Allergy RC581-607
spellingShingle	external genital endometriosis systemic immunity human papillomavirus of high oncogenic risk ureaplasma infection Immunologic diseases. Allergy RC581-607 L. F. Zaynetdinova L. F. Telesheva A. V. Koryaushkina S. V. Kvyatkovskaya E. A. Mezenceva K. V. Nikushkina FEATURES OF SYSTEM IMMUNITY IN WOMEN WITH ENDOMETRIOSIS AND GENITAL INFECTION
description	External genital endometriosis is an inflammatory, estrogen-dependent disease that develops predominantly in women of reproductive age and is characterized by the presence of pain syndrome and infertility. Today, endometriosis is one of the most common gynecological diseases in women of reproductive age, however, the etiology and pathogenesis of it are not completely clear. Violations of systemic immunity are most important in the pathogenesis of endometriosis. The literature data on the features of the immune response in endometriosis in combination with genital infection are few and contradictory. Purpose – to study the features of systemic immunity in women with external genital endometriosis and pathogens of genital infection.A total of 159 women with external genital endometriosis were examined. The main lymphocyte subpopulations, the functional activity of neutrophils and peripheral blood monocytes, and the content of cytokines in the blood serum were studied. A study of systemic immunity was performed in women with 1-2 and 3-4 stages of endometriosis, as well as depending on the presence of pathogens of genital infection. The presence of Chlamydia trachomatis, Ureaplasma spp., Mycoplasma genitalium, HSV1, 2/CMV, HPV in the endometrium, peritoneal fluid, and endometrioid heterotopies was determined. Statistical processing was performed using the IBM SPSS Statistics Version 22.2 statistical analysis software package.According to the results of the study, it was found that women with endometriosis of stages 1-2 show signs of systemic inflammation with a predominance of the Th2 type of immune response and inhibition of cellular immunity. A particular feature of HPV was an increase in T-NK lymphocytes, a decrease in IL-2 and neutrophil functional activity. The presence of Ureaplasma spp./Mycoplasma genitalium was characterized by a decrease in cellular immunity and an increase in T-NK cells. Only with HPV and Ureaplasma spp./Mycoplasma genitalium decreased synthesis of IL-2, IL-6. With 3-4 stages, the most significant changes in immunity were found in groups of women with genital infection. When HPV – a high level of IgA, increased IgM, IL-8. With Ureaplasma spp./Mycoplasma genitalium – inhibition of cellular immunity, high levels of IgA, reduction of neutrophil phagocytic activity.Thus, in women with endometriosis in the presence of pathogens of genital infection revealed features that may contribute to the development and progression of the disease.
format	article
author	L. F. Zaynetdinova L. F. Telesheva A. V. Koryaushkina S. V. Kvyatkovskaya E. A. Mezenceva K. V. Nikushkina
author_facet	L. F. Zaynetdinova L. F. Telesheva A. V. Koryaushkina S. V. Kvyatkovskaya E. A. Mezenceva K. V. Nikushkina
author_sort	L. F. Zaynetdinova
title	FEATURES OF SYSTEM IMMUNITY IN WOMEN WITH ENDOMETRIOSIS AND GENITAL INFECTION
title_short	FEATURES OF SYSTEM IMMUNITY IN WOMEN WITH ENDOMETRIOSIS AND GENITAL INFECTION
title_full	FEATURES OF SYSTEM IMMUNITY IN WOMEN WITH ENDOMETRIOSIS AND GENITAL INFECTION
title_fullStr	FEATURES OF SYSTEM IMMUNITY IN WOMEN WITH ENDOMETRIOSIS AND GENITAL INFECTION
title_full_unstemmed	FEATURES OF SYSTEM IMMUNITY IN WOMEN WITH ENDOMETRIOSIS AND GENITAL INFECTION
title_sort	features of system immunity in women with endometriosis and genital infection
publisher	SPb RAACI
publishDate	2019
url	https://doaj.org/article/61a2e5665719401f8a3b39d7df868277
work_keys_str_mv	AT lfzaynetdinova featuresofsystemimmunityinwomenwithendometriosisandgenitalinfection AT lftelesheva featuresofsystemimmunityinwomenwithendometriosisandgenitalinfection AT avkoryaushkina featuresofsystemimmunityinwomenwithendometriosisandgenitalinfection AT svkvyatkovskaya featuresofsystemimmunityinwomenwithendometriosisandgenitalinfection AT eamezenceva featuresofsystemimmunityinwomenwithendometriosisandgenitalinfection AT kvnikushkina featuresofsystemimmunityinwomenwithendometriosisandgenitalinfection
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FEATURES OF SYSTEM IMMUNITY IN WOMEN WITH ENDOMETRIOSIS AND GENITAL INFECTION

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