Senescent fibroblasts enhance early skin carcinogenic events via a paracrine MMP-PAR-1 axis.

Senescent fibroblasts enhance early skin carcinogenic events via a paracrine MMP-PAR-1 axis.

The incidence of carcinoma increases greatly with aging, but the cellular and molecular mechanisms underlying this correlation are only partly known. It is established that senescent fibroblasts promote the malignant progression of already-transformed cells through secretion of inflammatory mediator...

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Autores principales: Nicolas Malaquin, Chantal Vercamer, Fatima Bouali, Sébastien Martien, Emeric Deruy, Nicolas Wernert, Maggy Chwastyniak, Florence Pinet, Corinne Abbadie, Albin Pourtier
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/61a8198699d84c458665d7710fa84c80
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