Asymmetric cell division shapes naive and virtual memory T-cell immunity during ageing

Asymmetric cell division shapes naive and virtual memory T-cell immunity during ageing

Asymmetrical cell division helps to maintain cellular heterogeneity in the T cell compartment. Here the authors examine the differential immune responses built by naive and virtual memory T cells from young and aged individuals, and explore the effect of mTOR inhibition on asymmetrical cell division...

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Autores principales: Mariana Borsa, Niculò Barandun, Fabienne Gräbnitz, Isabel Barnstorf, Nicolas S. Baumann, Katharina Pallmer, Samira Baumann, Dominique Stark, Miroslav Balaz, Nathalie Oetiker, Franziska Wagen, Christian Wolfrum, Anna Katharina Simon, Nicole Joller, Yves Barral, Roman Spörri, Annette Oxenius
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
Q
Acceso en línea:https://doaj.org/article/61aae8a737c543db8b183a3356289468
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spelling oai:doaj.org-article:61aae8a737c543db8b183a33562894682021-12-02T15:36:11ZAsymmetric cell division shapes naive and virtual memory T-cell immunity during ageing10.1038/s41467-021-22954-y2041-1723https://doaj.org/article/61aae8a737c543db8b183a33562894682021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22954-yhttps://doaj.org/toc/2041-1723Asymmetrical cell division helps to maintain cellular heterogeneity in the T cell compartment. Here the authors examine the differential immune responses built by naive and virtual memory T cells from young and aged individuals, and explore the effect of mTOR inhibition on asymmetrical cell division and memory formation.Mariana BorsaNiculò BarandunFabienne GräbnitzIsabel BarnstorfNicolas S. BaumannKatharina PallmerSamira BaumannDominique StarkMiroslav BalazNathalie OetikerFranziska WagenChristian WolfrumAnna Katharina SimonNicole JollerYves BarralRoman SpörriAnnette OxeniusNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Mariana Borsa
Niculò Barandun
Fabienne Gräbnitz
Isabel Barnstorf
Nicolas S. Baumann
Katharina Pallmer
Samira Baumann
Dominique Stark
Miroslav Balaz
Nathalie Oetiker
Franziska Wagen
Christian Wolfrum
Anna Katharina Simon
Nicole Joller
Yves Barral
Roman Spörri
Annette Oxenius
Asymmetric cell division shapes naive and virtual memory T-cell immunity during ageing
description Asymmetrical cell division helps to maintain cellular heterogeneity in the T cell compartment. Here the authors examine the differential immune responses built by naive and virtual memory T cells from young and aged individuals, and explore the effect of mTOR inhibition on asymmetrical cell division and memory formation.
format article
author Mariana Borsa
Niculò Barandun
Fabienne Gräbnitz
Isabel Barnstorf
Nicolas S. Baumann
Katharina Pallmer
Samira Baumann
Dominique Stark
Miroslav Balaz
Nathalie Oetiker
Franziska Wagen
Christian Wolfrum
Anna Katharina Simon
Nicole Joller
Yves Barral
Roman Spörri
Annette Oxenius
author_facet Mariana Borsa
Niculò Barandun
Fabienne Gräbnitz
Isabel Barnstorf
Nicolas S. Baumann
Katharina Pallmer
Samira Baumann
Dominique Stark
Miroslav Balaz
Nathalie Oetiker
Franziska Wagen
Christian Wolfrum
Anna Katharina Simon
Nicole Joller
Yves Barral
Roman Spörri
Annette Oxenius
author_sort Mariana Borsa
title Asymmetric cell division shapes naive and virtual memory T-cell immunity during ageing
title_short Asymmetric cell division shapes naive and virtual memory T-cell immunity during ageing
title_full Asymmetric cell division shapes naive and virtual memory T-cell immunity during ageing
title_fullStr Asymmetric cell division shapes naive and virtual memory T-cell immunity during ageing
title_full_unstemmed Asymmetric cell division shapes naive and virtual memory T-cell immunity during ageing
title_sort asymmetric cell division shapes naive and virtual memory t-cell immunity during ageing
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/61aae8a737c543db8b183a3356289468
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