Relationship between Urine Creatinine and Urine Osmolality in Spot Samples among Men and Women in the Danish Diet Cancer and Health Cohort

Assays of urine biomarkers often use urine creatinine to account for urinary dilution, even though creatinine levels are influenced by underlying physiology and muscle catabolism. Urine osmolality—a measure of dissolved particles including ions, glucose, and urea—is thought to provide a more robust...

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Autores principales:	Selinay Ozdemir, Clara G. Sears, James M. Harrington, Aslak Harbo Poulsen, Jessie Buckley, Chanelle J. Howe, Katherine A. James, Anne Tjonneland, Gregory A. Wellenius, Ole Raaschou-Nielsen, Jaymie Meliker
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	biomonitoring urine creatinine urine dilution urine normalization urine osmolality Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/61ab24eaf18046bcb38c9e18067d2844
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spelling	oai:doaj.org-article:61ab24eaf18046bcb38c9e18067d28442021-11-25T19:08:03ZRelationship between Urine Creatinine and Urine Osmolality in Spot Samples among Men and Women in the Danish Diet Cancer and Health Cohort10.3390/toxics91102822305-6304https://doaj.org/article/61ab24eaf18046bcb38c9e18067d28442021-11-01T00:00:00Zhttps://www.mdpi.com/2305-6304/9/11/282https://doaj.org/toc/2305-6304Assays of urine biomarkers often use urine creatinine to account for urinary dilution, even though creatinine levels are influenced by underlying physiology and muscle catabolism. Urine osmolality—a measure of dissolved particles including ions, glucose, and urea—is thought to provide a more robust marker of urinary dilution but is seldom measured. The relationship between urine osmolality and creatinine is not well understood. We calculated correlation coefficients between urine creatinine and osmolality among 1375 members of a subcohort of the Danish Diet, Cancer, and Health Cohort, and within different subgroups. We used linear regression to relate creatinine with osmolality, and a lasso selection procedure to identify other variables that explain remaining variability in osmolality. Spearman correlation between urine creatinine and osmolality was strong overall (ρ = 0.90; 95% CI: 0.89–0.91) and in most subgroups. Linear regression showed that urine creatinine explained 60% of the variability in urine osmolality, with another 9% explained by urine thallium (Tl), cesium (Cs), and strontium (Sr). Urinary creatinine and osmolality are strongly correlated, although urine Tl, Cs, and Sr might help supplement urine creatinine for purposes of urine dilution adjustment when osmolality is not available.Selinay OzdemirClara G. SearsJames M. HarringtonAslak Harbo PoulsenJessie BuckleyChanelle J. HoweKatherine A. JamesAnne TjonnelandGregory A. WelleniusOle Raaschou-NielsenJaymie MelikerMDPI AGarticlebiomonitoringurine creatinineurine dilutionurine normalizationurine osmolalityChemical technologyTP1-1185ENToxics, Vol 9, Iss 282, p 282 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	biomonitoring urine creatinine urine dilution urine normalization urine osmolality Chemical technology TP1-1185
spellingShingle	biomonitoring urine creatinine urine dilution urine normalization urine osmolality Chemical technology TP1-1185 Selinay Ozdemir Clara G. Sears James M. Harrington Aslak Harbo Poulsen Jessie Buckley Chanelle J. Howe Katherine A. James Anne Tjonneland Gregory A. Wellenius Ole Raaschou-Nielsen Jaymie Meliker Relationship between Urine Creatinine and Urine Osmolality in Spot Samples among Men and Women in the Danish Diet Cancer and Health Cohort
description	Assays of urine biomarkers often use urine creatinine to account for urinary dilution, even though creatinine levels are influenced by underlying physiology and muscle catabolism. Urine osmolality—a measure of dissolved particles including ions, glucose, and urea—is thought to provide a more robust marker of urinary dilution but is seldom measured. The relationship between urine osmolality and creatinine is not well understood. We calculated correlation coefficients between urine creatinine and osmolality among 1375 members of a subcohort of the Danish Diet, Cancer, and Health Cohort, and within different subgroups. We used linear regression to relate creatinine with osmolality, and a lasso selection procedure to identify other variables that explain remaining variability in osmolality. Spearman correlation between urine creatinine and osmolality was strong overall (ρ = 0.90; 95% CI: 0.89–0.91) and in most subgroups. Linear regression showed that urine creatinine explained 60% of the variability in urine osmolality, with another 9% explained by urine thallium (Tl), cesium (Cs), and strontium (Sr). Urinary creatinine and osmolality are strongly correlated, although urine Tl, Cs, and Sr might help supplement urine creatinine for purposes of urine dilution adjustment when osmolality is not available.
format	article
author	Selinay Ozdemir Clara G. Sears James M. Harrington Aslak Harbo Poulsen Jessie Buckley Chanelle J. Howe Katherine A. James Anne Tjonneland Gregory A. Wellenius Ole Raaschou-Nielsen Jaymie Meliker
author_facet	Selinay Ozdemir Clara G. Sears James M. Harrington Aslak Harbo Poulsen Jessie Buckley Chanelle J. Howe Katherine A. James Anne Tjonneland Gregory A. Wellenius Ole Raaschou-Nielsen Jaymie Meliker
author_sort	Selinay Ozdemir
title	Relationship between Urine Creatinine and Urine Osmolality in Spot Samples among Men and Women in the Danish Diet Cancer and Health Cohort
title_short	Relationship between Urine Creatinine and Urine Osmolality in Spot Samples among Men and Women in the Danish Diet Cancer and Health Cohort
title_full	Relationship between Urine Creatinine and Urine Osmolality in Spot Samples among Men and Women in the Danish Diet Cancer and Health Cohort
title_fullStr	Relationship between Urine Creatinine and Urine Osmolality in Spot Samples among Men and Women in the Danish Diet Cancer and Health Cohort
title_full_unstemmed	Relationship between Urine Creatinine and Urine Osmolality in Spot Samples among Men and Women in the Danish Diet Cancer and Health Cohort
title_sort	relationship between urine creatinine and urine osmolality in spot samples among men and women in the danish diet cancer and health cohort
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/61ab24eaf18046bcb38c9e18067d2844
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Relationship between Urine Creatinine and Urine Osmolality in Spot Samples among Men and Women in the Danish Diet Cancer and Health Cohort

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