Relationship between fatty pancreas and hypertriglyceridemic waist phenotype: a cross-sectional study

Abstract Hypertriglyceridemic waist phenotype (HTWP) and its quantitative indicator, waist circumference-triglyceride index (WTI), are common quantitative indices of visceral obesity and are closely related to metabolic diseases. The purpose of this study was to investigate the relationship between...

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Autores principales:	Xiaoping Yu, Dan Wang, Weiming Xiao, Xinlin Shi, Qiang She, Hongguang Sun, Tingyue Qi, Renyan Xu, Guiqing Li, Xinnong Liu, Weijuan Gong, Zhigang Yan, Yanbing Ding, Guotao Lu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/61ab4eb69951403691160394b4529910
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spelling	oai:doaj.org-article:61ab4eb69951403691160394b45299102021-12-02T12:03:15ZRelationship between fatty pancreas and hypertriglyceridemic waist phenotype: a cross-sectional study10.1038/s41598-020-78883-12045-2322https://doaj.org/article/61ab4eb69951403691160394b45299102020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78883-1https://doaj.org/toc/2045-2322Abstract Hypertriglyceridemic waist phenotype (HTWP) and its quantitative indicator, waist circumference-triglyceride index (WTI), are common quantitative indices of visceral obesity and are closely related to metabolic diseases. The purpose of this study was to investigate the relationship between fatty pancreas (FP) and HTWP in China. FP was diagnosed using trans-abdominal ultrasonography in all participants. According to the waist circumference and serum triglyceride levels, the participants were divided into four phenotype groups: normal waist circumference-normal triglyceride, normal waist circumference-elevated triglyceride, elevated waist circumference-normal triglyceride, and elevated waist circumference-elevated triglyceride (indicating HTWP). Clinical characteristics and biochemical indices were compared among the groups. Receiver operating characteristic (ROC) curves were used to evaluate the utility of WTI as a reference factor for FP screening. The HTWP group had a higher prevalence of metabolic syndrome (84.2%), FP (10.4%), fatty liver (64.5%), and hypertension (15.8%) than the other three phenotype groups. The occurrence rate of HTWP and the median WTI were significantly higher in participants with FP than in those without FP (54.7% vs 21.0%, 222 ± 135 vs 142 ± 141, p < 0.001). In the ROC curve analysis, when the maximum area under the curve was 0.746, the WTI was 107.09 and the corresponding sensitivity and specificity were 90.6% and 51.9%, respectively. HTWP is closely associated with FP and can be used as a reference factor for FP screening.Xiaoping YuDan WangWeiming XiaoXinlin ShiQiang SheHongguang SunTingyue QiRenyan XuGuiqing LiXinnong LiuWeijuan GongZhigang YanYanbing DingGuotao LuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiaoping Yu Dan Wang Weiming Xiao Xinlin Shi Qiang She Hongguang Sun Tingyue Qi Renyan Xu Guiqing Li Xinnong Liu Weijuan Gong Zhigang Yan Yanbing Ding Guotao Lu Relationship between fatty pancreas and hypertriglyceridemic waist phenotype: a cross-sectional study
description	Abstract Hypertriglyceridemic waist phenotype (HTWP) and its quantitative indicator, waist circumference-triglyceride index (WTI), are common quantitative indices of visceral obesity and are closely related to metabolic diseases. The purpose of this study was to investigate the relationship between fatty pancreas (FP) and HTWP in China. FP was diagnosed using trans-abdominal ultrasonography in all participants. According to the waist circumference and serum triglyceride levels, the participants were divided into four phenotype groups: normal waist circumference-normal triglyceride, normal waist circumference-elevated triglyceride, elevated waist circumference-normal triglyceride, and elevated waist circumference-elevated triglyceride (indicating HTWP). Clinical characteristics and biochemical indices were compared among the groups. Receiver operating characteristic (ROC) curves were used to evaluate the utility of WTI as a reference factor for FP screening. The HTWP group had a higher prevalence of metabolic syndrome (84.2%), FP (10.4%), fatty liver (64.5%), and hypertension (15.8%) than the other three phenotype groups. The occurrence rate of HTWP and the median WTI were significantly higher in participants with FP than in those without FP (54.7% vs 21.0%, 222 ± 135 vs 142 ± 141, p < 0.001). In the ROC curve analysis, when the maximum area under the curve was 0.746, the WTI was 107.09 and the corresponding sensitivity and specificity were 90.6% and 51.9%, respectively. HTWP is closely associated with FP and can be used as a reference factor for FP screening.
format	article
author	Xiaoping Yu Dan Wang Weiming Xiao Xinlin Shi Qiang She Hongguang Sun Tingyue Qi Renyan Xu Guiqing Li Xinnong Liu Weijuan Gong Zhigang Yan Yanbing Ding Guotao Lu
author_facet	Xiaoping Yu Dan Wang Weiming Xiao Xinlin Shi Qiang She Hongguang Sun Tingyue Qi Renyan Xu Guiqing Li Xinnong Liu Weijuan Gong Zhigang Yan Yanbing Ding Guotao Lu
author_sort	Xiaoping Yu
title	Relationship between fatty pancreas and hypertriglyceridemic waist phenotype: a cross-sectional study
title_short	Relationship between fatty pancreas and hypertriglyceridemic waist phenotype: a cross-sectional study
title_full	Relationship between fatty pancreas and hypertriglyceridemic waist phenotype: a cross-sectional study
title_fullStr	Relationship between fatty pancreas and hypertriglyceridemic waist phenotype: a cross-sectional study
title_full_unstemmed	Relationship between fatty pancreas and hypertriglyceridemic waist phenotype: a cross-sectional study
title_sort	relationship between fatty pancreas and hypertriglyceridemic waist phenotype: a cross-sectional study
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/61ab4eb69951403691160394b4529910
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Relationship between fatty pancreas and hypertriglyceridemic waist phenotype: a cross-sectional study

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