An HDAC6-dependent surveillance mechanism suppresses tau-mediated neurodegeneration and cognitive decline

HDAC6 is a tau deacetylase and acetylation of tau inhibits its function and promotes aggregation. Here the authors show that HDAC6 protects against tau accumulation in a mouse model of tauopathy.

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Autores principales:	Hanna Trzeciakiewicz, Deepa Ajit, Jui-Heng Tseng, Youjun Chen, Aditi Ajit, Zarin Tabassum, Rebecca Lobrovich, Claire Peterson, Natallia V. Riddick, Michelle S. Itano, Ashutosh Tripathy, Sheryl S. Moy, Virginia M. Y. Lee, John Q. Trojanowski, David J. Irwin, Todd J. Cohen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/61ab6286279144ac8d59a59cc0805267
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spelling	oai:doaj.org-article:61ab6286279144ac8d59a59cc08052672021-12-02T17:31:07ZAn HDAC6-dependent surveillance mechanism suppresses tau-mediated neurodegeneration and cognitive decline10.1038/s41467-020-19317-42041-1723https://doaj.org/article/61ab6286279144ac8d59a59cc08052672020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19317-4https://doaj.org/toc/2041-1723HDAC6 is a tau deacetylase and acetylation of tau inhibits its function and promotes aggregation. Here the authors show that HDAC6 protects against tau accumulation in a mouse model of tauopathy.Hanna TrzeciakiewiczDeepa AjitJui-Heng TsengYoujun ChenAditi AjitZarin TabassumRebecca LobrovichClaire PetersonNatallia V. RiddickMichelle S. ItanoAshutosh TripathySheryl S. MoyVirginia M. Y. LeeJohn Q. TrojanowskiDavid J. IrwinTodd J. CohenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hanna Trzeciakiewicz Deepa Ajit Jui-Heng Tseng Youjun Chen Aditi Ajit Zarin Tabassum Rebecca Lobrovich Claire Peterson Natallia V. Riddick Michelle S. Itano Ashutosh Tripathy Sheryl S. Moy Virginia M. Y. Lee John Q. Trojanowski David J. Irwin Todd J. Cohen An HDAC6-dependent surveillance mechanism suppresses tau-mediated neurodegeneration and cognitive decline
description	HDAC6 is a tau deacetylase and acetylation of tau inhibits its function and promotes aggregation. Here the authors show that HDAC6 protects against tau accumulation in a mouse model of tauopathy.
format	article
author	Hanna Trzeciakiewicz Deepa Ajit Jui-Heng Tseng Youjun Chen Aditi Ajit Zarin Tabassum Rebecca Lobrovich Claire Peterson Natallia V. Riddick Michelle S. Itano Ashutosh Tripathy Sheryl S. Moy Virginia M. Y. Lee John Q. Trojanowski David J. Irwin Todd J. Cohen
author_facet	Hanna Trzeciakiewicz Deepa Ajit Jui-Heng Tseng Youjun Chen Aditi Ajit Zarin Tabassum Rebecca Lobrovich Claire Peterson Natallia V. Riddick Michelle S. Itano Ashutosh Tripathy Sheryl S. Moy Virginia M. Y. Lee John Q. Trojanowski David J. Irwin Todd J. Cohen
author_sort	Hanna Trzeciakiewicz
title	An HDAC6-dependent surveillance mechanism suppresses tau-mediated neurodegeneration and cognitive decline
title_short	An HDAC6-dependent surveillance mechanism suppresses tau-mediated neurodegeneration and cognitive decline
title_full	An HDAC6-dependent surveillance mechanism suppresses tau-mediated neurodegeneration and cognitive decline
title_fullStr	An HDAC6-dependent surveillance mechanism suppresses tau-mediated neurodegeneration and cognitive decline
title_full_unstemmed	An HDAC6-dependent surveillance mechanism suppresses tau-mediated neurodegeneration and cognitive decline
title_sort	hdac6-dependent surveillance mechanism suppresses tau-mediated neurodegeneration and cognitive decline
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/61ab6286279144ac8d59a59cc0805267
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An HDAC6-dependent surveillance mechanism suppresses tau-mediated neurodegeneration and cognitive decline

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