Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ)

The tumor suppressor p53 is mutated in more than half of human cancers and the compound methylene quinuclidinone (MQ) was shown to reactivate p53 mutants by binding covalently to cysteine residues. Here, the authors present crystal structures of wild-type and cancer related p53 mutant core domains b...

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Autores principales: Oksana Degtjarik, Dmitrij Golovenko, Yael Diskin-Posner, Lars Abrahmsén, Haim Rozenberg, Zippora Shakked
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/61ab66026ad342f6901e1b078e2ffc95
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