Associations of hypertension burden on subsequent dementia: a population-based cohort study

Abstract In this nationwide cohort study, we assessed the effects of hypertension burden and blood pressure (BP) control on dementia in different age subgroups. From the Korean National Health Insurance Service-Health Screening cohort from January 1, 2005 to December 31, 2013, we enrolled 428,976 su...

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Autores principales:	Hyunjean Jung, Pil-Sung Yang, Daehoon Kim, Eunsun Jang, Hee Tae Yu, Tae-Hoon Kim, Jung-Hoon Sung, Hui-Nam Pak, Moon-Hyoung Lee, Gregory Y. H. Lip, Boyoung Joung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/61b086dfdc2e4a8583633e6e4abdd4a9
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spelling	oai:doaj.org-article:61b086dfdc2e4a8583633e6e4abdd4a92021-12-02T17:52:25ZAssociations of hypertension burden on subsequent dementia: a population-based cohort study10.1038/s41598-021-91923-82045-2322https://doaj.org/article/61b086dfdc2e4a8583633e6e4abdd4a92021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91923-8https://doaj.org/toc/2045-2322Abstract In this nationwide cohort study, we assessed the effects of hypertension burden and blood pressure (BP) control on dementia in different age subgroups. From the Korean National Health Insurance Service-Health Screening cohort from January 1, 2005 to December 31, 2013, we enrolled 428,976 subjects aged 40–79 years without previous diagnosis of dementia or stroke. During a mean follow-up of 7.3 ± 1.5 years, 9435 (2.2%) were diagnosed with dementia. Per 10 mmHg increase in systolic BP (SBP), risk of dementia was increased by 22% (95% confidence interval [CI] 1.15–1.30) in subjects aged 40–59 years and 8% (95% CI 1.04–1.11) in subjects aged 60–69 years. No significant associations were observed in subjects aged ≥ 70 years. Among subjects aged 40–59 years, both vascular and Alzheimer’s dementia risks were increased with increasing SBP. Increasing hypertension burden (proportion of days with increased BP) was associated with higher dementia risk (hazard ratio [HR] 1.09 per 10% increase, 95% CI 1.08–1.10). Among patients with baseline SBP ≥ 140 mmHg, optimal follow-up SBP (120–139 mmHg) was associated with decreased dementia risk (HR 0.69, 95% CI 0.50–0.95). Hypertension burden was associated with higher risks of dementia. Adequate BP control was associated with lower risk of dementia in individuals aged < 70 years.Hyunjean JungPil-Sung YangDaehoon KimEunsun JangHee Tae YuTae-Hoon KimJung-Hoon SungHui-Nam PakMoon-Hyoung LeeGregory Y. H. LipBoyoung JoungNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hyunjean Jung Pil-Sung Yang Daehoon Kim Eunsun Jang Hee Tae Yu Tae-Hoon Kim Jung-Hoon Sung Hui-Nam Pak Moon-Hyoung Lee Gregory Y. H. Lip Boyoung Joung Associations of hypertension burden on subsequent dementia: a population-based cohort study
description	Abstract In this nationwide cohort study, we assessed the effects of hypertension burden and blood pressure (BP) control on dementia in different age subgroups. From the Korean National Health Insurance Service-Health Screening cohort from January 1, 2005 to December 31, 2013, we enrolled 428,976 subjects aged 40–79 years without previous diagnosis of dementia or stroke. During a mean follow-up of 7.3 ± 1.5 years, 9435 (2.2%) were diagnosed with dementia. Per 10 mmHg increase in systolic BP (SBP), risk of dementia was increased by 22% (95% confidence interval [CI] 1.15–1.30) in subjects aged 40–59 years and 8% (95% CI 1.04–1.11) in subjects aged 60–69 years. No significant associations were observed in subjects aged ≥ 70 years. Among subjects aged 40–59 years, both vascular and Alzheimer’s dementia risks were increased with increasing SBP. Increasing hypertension burden (proportion of days with increased BP) was associated with higher dementia risk (hazard ratio [HR] 1.09 per 10% increase, 95% CI 1.08–1.10). Among patients with baseline SBP ≥ 140 mmHg, optimal follow-up SBP (120–139 mmHg) was associated with decreased dementia risk (HR 0.69, 95% CI 0.50–0.95). Hypertension burden was associated with higher risks of dementia. Adequate BP control was associated with lower risk of dementia in individuals aged < 70 years.
format	article
author	Hyunjean Jung Pil-Sung Yang Daehoon Kim Eunsun Jang Hee Tae Yu Tae-Hoon Kim Jung-Hoon Sung Hui-Nam Pak Moon-Hyoung Lee Gregory Y. H. Lip Boyoung Joung
author_facet	Hyunjean Jung Pil-Sung Yang Daehoon Kim Eunsun Jang Hee Tae Yu Tae-Hoon Kim Jung-Hoon Sung Hui-Nam Pak Moon-Hyoung Lee Gregory Y. H. Lip Boyoung Joung
author_sort	Hyunjean Jung
title	Associations of hypertension burden on subsequent dementia: a population-based cohort study
title_short	Associations of hypertension burden on subsequent dementia: a population-based cohort study
title_full	Associations of hypertension burden on subsequent dementia: a population-based cohort study
title_fullStr	Associations of hypertension burden on subsequent dementia: a population-based cohort study
title_full_unstemmed	Associations of hypertension burden on subsequent dementia: a population-based cohort study
title_sort	associations of hypertension burden on subsequent dementia: a population-based cohort study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/61b086dfdc2e4a8583633e6e4abdd4a9
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Associations of hypertension burden on subsequent dementia: a population-based cohort study

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