Association of p53 Arg/Pro Polymorphism at Codon 72 with Risk of Breast Cancer in East Azerbaijani Women

BACKGROUND AND OBJECTIVE: Breast cancer is most common cancer among women in the world and one third women affected by this cancer. P53 gene is one of the most important tumor suppressor genes. Investigations show G to C polymorphism at codon 72 of p53 gene, is associated with the increasing of canc...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	MA Hossein Pour Feizi, R Ravanbakhsh Gavgani, R Pourahmad, N Pouladi, P Azarfam, V Montazeri
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2012
Materias:	genetic polymorphism p53 breast cancer Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/61b2024705b9442abd3c293218d193b8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:61b2024705b9442abd3c293218d193b8
record_format	dspace
spelling	oai:doaj.org-article:61b2024705b9442abd3c293218d193b82021-11-10T08:53:02ZAssociation of p53 Arg/Pro Polymorphism at Codon 72 with Risk of Breast Cancer in East Azerbaijani Women1561-41072251-7170https://doaj.org/article/61b2024705b9442abd3c293218d193b82012-03-01T00:00:00Zhttp://jbums.org/article-1-4044-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Breast cancer is most common cancer among women in the world and one third women affected by this cancer. P53 gene is one of the most important tumor suppressor genes. Investigations show G to C polymorphism at codon 72 of p53 gene, is associated with the increasing of cancer, and perhaps it can be regarded as a predisposing marker for breast cancer. This study was done to assess the association of p53 Arg/Pro polymorphism at codon 72 with risk of breast cancer in women.METHODS: This case-control study was conducted on 126 patients with invasive and insitu, as well as 99 control individuals as controls from Tabriz hospitals, DNA extraction was conducted using proteinase K method, different genotype of codon 72 of gene p53 were determined using allele-specific polymerase chain reaction (PCR) and direct DNA sequencing and compared. FINDINGS: In the control group, the genotype distribution of p53 polymorphism, showed 30.3%, 50.5% and 19.2% for the Arg/Arg, Arg/Pro, Pro/Pro Genotypes, respectively. In the cancer group, the distribution was 44.4%, 34.9% and 20.6% for the Arg/Arg, Arg/Pro and Pro/Pro genotypes, respectively. Distribution differences in the p53 codon 72 polymorphism between the cases and controls were statistically significant (p<0.05).CONCLUSION: This study indicates that p53 codon polymorphism is a genetic predisposing factor for breast cancer in East Azerbijan’s women. However, further studies are needed to determine the role of p53 codon 72 polymorphism in breast cancer.MA Hossein Pour FeiziR Ravanbakhsh GavganiR PourahmadN PouladiP AzarfamV MontazeriBabol University of Medical Sciencesarticlegenetic polymorphismp53breast cancerMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 14, Iss 2, Pp 31-38 (2012)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	genetic polymorphism p53 breast cancer Medicine R Medicine (General) R5-920
spellingShingle	genetic polymorphism p53 breast cancer Medicine R Medicine (General) R5-920 MA Hossein Pour Feizi R Ravanbakhsh Gavgani R Pourahmad N Pouladi P Azarfam V Montazeri Association of p53 Arg/Pro Polymorphism at Codon 72 with Risk of Breast Cancer in East Azerbaijani Women
description	BACKGROUND AND OBJECTIVE: Breast cancer is most common cancer among women in the world and one third women affected by this cancer. P53 gene is one of the most important tumor suppressor genes. Investigations show G to C polymorphism at codon 72 of p53 gene, is associated with the increasing of cancer, and perhaps it can be regarded as a predisposing marker for breast cancer. This study was done to assess the association of p53 Arg/Pro polymorphism at codon 72 with risk of breast cancer in women.METHODS: This case-control study was conducted on 126 patients with invasive and insitu, as well as 99 control individuals as controls from Tabriz hospitals, DNA extraction was conducted using proteinase K method, different genotype of codon 72 of gene p53 were determined using allele-specific polymerase chain reaction (PCR) and direct DNA sequencing and compared. FINDINGS: In the control group, the genotype distribution of p53 polymorphism, showed 30.3%, 50.5% and 19.2% for the Arg/Arg, Arg/Pro, Pro/Pro Genotypes, respectively. In the cancer group, the distribution was 44.4%, 34.9% and 20.6% for the Arg/Arg, Arg/Pro and Pro/Pro genotypes, respectively. Distribution differences in the p53 codon 72 polymorphism between the cases and controls were statistically significant (p<0.05).CONCLUSION: This study indicates that p53 codon polymorphism is a genetic predisposing factor for breast cancer in East Azerbijan’s women. However, further studies are needed to determine the role of p53 codon 72 polymorphism in breast cancer.
format	article
author	MA Hossein Pour Feizi R Ravanbakhsh Gavgani R Pourahmad N Pouladi P Azarfam V Montazeri
author_facet	MA Hossein Pour Feizi R Ravanbakhsh Gavgani R Pourahmad N Pouladi P Azarfam V Montazeri
author_sort	MA Hossein Pour Feizi
title	Association of p53 Arg/Pro Polymorphism at Codon 72 with Risk of Breast Cancer in East Azerbaijani Women
title_short	Association of p53 Arg/Pro Polymorphism at Codon 72 with Risk of Breast Cancer in East Azerbaijani Women
title_full	Association of p53 Arg/Pro Polymorphism at Codon 72 with Risk of Breast Cancer in East Azerbaijani Women
title_fullStr	Association of p53 Arg/Pro Polymorphism at Codon 72 with Risk of Breast Cancer in East Azerbaijani Women
title_full_unstemmed	Association of p53 Arg/Pro Polymorphism at Codon 72 with Risk of Breast Cancer in East Azerbaijani Women
title_sort	association of p53 arg/pro polymorphism at codon 72 with risk of breast cancer in east azerbaijani women
publisher	Babol University of Medical Sciences
publishDate	2012
url	https://doaj.org/article/61b2024705b9442abd3c293218d193b8
work_keys_str_mv	AT mahosseinpourfeizi associationofp53argpropolymorphismatcodon72withriskofbreastcancerineastazerbaijaniwomen AT rravanbakhshgavgani associationofp53argpropolymorphismatcodon72withriskofbreastcancerineastazerbaijaniwomen AT rpourahmad associationofp53argpropolymorphismatcodon72withriskofbreastcancerineastazerbaijaniwomen AT npouladi associationofp53argpropolymorphismatcodon72withriskofbreastcancerineastazerbaijaniwomen AT pazarfam associationofp53argpropolymorphismatcodon72withriskofbreastcancerineastazerbaijaniwomen AT vmontazeri associationofp53argpropolymorphismatcodon72withriskofbreastcancerineastazerbaijaniwomen
_version_	1718440378685718528

Association of p53 Arg/Pro Polymorphism at Codon 72 with Risk of Breast Cancer in East Azerbaijani Women

Ejemplares similares