Astroglia in Autism Spectrum Disorder

Autism spectrum disorder (ASD) is an umbrella term encompassing several neurodevelopmental disorders such as Asperger syndrome or autism. It is characterised by the occurrence of distinct deficits in social behaviour and communication and repetitive patterns of behaviour. The symptoms may be of diff...

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Autores principales:	Kinga Gzielo, Agnieszka Nikiforuk
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	autism astrocytes glia Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/61b3b4142b95473fb72b52b3ce9f4aaa
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id	oai:doaj.org-article:61b3b4142b95473fb72b52b3ce9f4aaa
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spelling	oai:doaj.org-article:61b3b4142b95473fb72b52b3ce9f4aaa2021-11-11T17:00:56ZAstroglia in Autism Spectrum Disorder10.3390/ijms2221115441422-00671661-6596https://doaj.org/article/61b3b4142b95473fb72b52b3ce9f4aaa2021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11544https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Autism spectrum disorder (ASD) is an umbrella term encompassing several neurodevelopmental disorders such as Asperger syndrome or autism. It is characterised by the occurrence of distinct deficits in social behaviour and communication and repetitive patterns of behaviour. The symptoms may be of different intensity and may vary in types. Risk factors for ASD include disturbed brain homeostasis, genetic predispositions, or inflammation during the prenatal period caused by viruses or bacteria. The number of diagnosed cases is growing, but the main cause and mechanism leading to ASD is still uncertain. Recent findings from animal models and human cases highlight the contribution of glia to the ASD pathophysiology. It is known that glia cells are not only “gluing” neurons together but are key players participating in different processes crucial for proper brain functioning, including neurogenesis, synaptogenesis, inflammation, myelination, proper glutamate processing and many others. Despite the prerequisites for the involvement of glia in the processes related to the onset of autism, there are far too little data regarding the engagement of these cells in the development of ASD.Kinga GzieloAgnieszka NikiforukMDPI AGarticleautismastrocytesgliaBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11544, p 11544 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	autism astrocytes glia Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	autism astrocytes glia Biology (General) QH301-705.5 Chemistry QD1-999 Kinga Gzielo Agnieszka Nikiforuk Astroglia in Autism Spectrum Disorder
description	Autism spectrum disorder (ASD) is an umbrella term encompassing several neurodevelopmental disorders such as Asperger syndrome or autism. It is characterised by the occurrence of distinct deficits in social behaviour and communication and repetitive patterns of behaviour. The symptoms may be of different intensity and may vary in types. Risk factors for ASD include disturbed brain homeostasis, genetic predispositions, or inflammation during the prenatal period caused by viruses or bacteria. The number of diagnosed cases is growing, but the main cause and mechanism leading to ASD is still uncertain. Recent findings from animal models and human cases highlight the contribution of glia to the ASD pathophysiology. It is known that glia cells are not only “gluing” neurons together but are key players participating in different processes crucial for proper brain functioning, including neurogenesis, synaptogenesis, inflammation, myelination, proper glutamate processing and many others. Despite the prerequisites for the involvement of glia in the processes related to the onset of autism, there are far too little data regarding the engagement of these cells in the development of ASD.
format	article
author	Kinga Gzielo Agnieszka Nikiforuk
author_facet	Kinga Gzielo Agnieszka Nikiforuk
author_sort	Kinga Gzielo
title	Astroglia in Autism Spectrum Disorder
title_short	Astroglia in Autism Spectrum Disorder
title_full	Astroglia in Autism Spectrum Disorder
title_fullStr	Astroglia in Autism Spectrum Disorder
title_full_unstemmed	Astroglia in Autism Spectrum Disorder
title_sort	astroglia in autism spectrum disorder
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/61b3b4142b95473fb72b52b3ce9f4aaa
work_keys_str_mv	AT kingagzielo astrogliainautismspectrumdisorder AT agnieszkanikiforuk astrogliainautismspectrumdisorder
_version_	1718432179884654592

Astroglia in Autism Spectrum Disorder

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